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    Htr3a 5-hydroxytryptamine receptor 3A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79246, updated on 26-Sep-2017
    Official Symbol
    Htr3aprovided by RGD
    Official Full Name
    5-hydroxytryptamine receptor 3Aprovided by RGD
    Primary source
    RGD:61818
    See related
    Ensembl:ENSRNOG00000006595
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    5HT3; Htr3; 5-HT3; 5-HT3A
    Summary
    receptor for 5-hydroxytryptamine (serotonin); functions as a ligand-gated ion channel [RGD, Feb 2006]
    Orthologs
    Location:
    8q23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (53211436..53223878, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (51803895..51816278, complement)

    Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene nicotinamide N-methyltransferase Neighboring gene zinc finger and BTB domain containing 16 Neighboring gene 5-hydroxytryptamine receptor 3B Neighboring gene PCNA-associated factor-like Neighboring gene ubiquitin specific peptidase 28

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    serotonin binding IEA
    Inferred from Electronic Annotation
    more info
     
    serotonin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    serotonin-gated cation-selective channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serotonin-gated cation-selective channel activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to cocaine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
     
    cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    serotonin-activated cation-selective channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    serotonin-activated cation-selective channel complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    5-hydroxytryptamine receptor 3A
    Names
    5-HT-3
    5-HT3 receptor
    5-HT3-A
    5-HT3R
    5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
    5-hydroxytryptamine receptor 3
    serotonin receptor 3A
    serotonin-gated ion channel receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024394.2NP_077370.2  5-hydroxytryptamine receptor 3A precursor

      See identical proteins and their annotated locations for NP_077370.2

      Status: PROVISIONAL

      Source sequence(s)
      CB583270, U59672
      UniProtKB/Swiss-Prot
      P35563
      UniProtKB/TrEMBL
      Q62999
      Related
      ENSRNOP00000008965.4, ENSRNOT00000008965.4
      Conserved Domains (3) summary
      TIGR00860
      Location:5477
      LIC; Cation transporter family protein
      pfam02931
      Location:41247
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:254473
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

      Range
      53211436..53223878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595928.1XP_017451417.1  5-hydroxytryptamine receptor 3A isoform X2

    2. XM_006243021.3XP_006243083.1  5-hydroxytryptamine receptor 3A isoform X1

      See identical proteins and their annotated locations for XP_006243083.1

      Conserved Domains (3) summary
      TIGR00860
      Location:5482
      LIC; Cation transporter family protein
      pfam02931
      Location:41247
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:254478
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    Alternate Rn_Celera

    Genomic

    1. AC_000076.1 Alternate Rn_Celera

      Range
      48799808..48812052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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