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    WAPL WAPL cohesin release factor [ Homo sapiens (human) ]

    Gene ID: 23063, updated on 5-Nov-2017
    Official Symbol
    WAPLprovided by HGNC
    Official Full Name
    WAPL cohesin release factorprovided by HGNC
    Primary source
    HGNC:HGNC:23293
    See related
    Ensembl:ENSG00000062650 MIM:610754; Vega:OTTHUMG00000018651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FOE; WAPAL; KIAA0261
    Orthologs
    Location:
    10q23.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (86435256..86521816, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (88195013..88281541, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor delta type subunit 1 Neighboring gene RNA, 5S ribosomal pseudogene 322 Neighboring gene microRNA 346 Neighboring gene RNA, U6 small nuclear 780, pseudogene Neighboring gene uncharacterized LOC105378408 Neighboring gene uncharacterized LOC105378407 Neighboring gene uncharacterized LOC105378406

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    NHGRI GWA Catalog
    Genome-wide association study of periodontal pathogen colonization.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    NHGRI GWA Catalog
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cohesin Loading onto Chromatin, organism-specific biosystem (from REACTOME)
      Cohesin Loading onto Chromatin, organism-specific biosystemIn mitotic telophase, as chromosomes decondense, cohesin complex associated with PDS5 (PDS5A and PDS5B) and WAPAL (WAPL) proteins is loaded onto chromatin (Shintomi and Hirano, 2009, Kueng et al. 200...
    • Establishment of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
      Establishment of Sister Chromatid Cohesion, organism-specific biosystemThe cohesin complex loads onto chromatin in telophase, but its association with chromatin remains transient, dynamic until the S-phase of the cell cycle, presumably because the cohesin-bound NIPBL:MA...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
    • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
    • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
      Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
    • Mitotic Telophase/Cytokinesis, organism-specific biosystem (from REACTOME)
      Mitotic Telophase/Cytokinesis, organism-specific biosystemIn this final phase of mitosis, new membranes are formed around two sets of chromatids and two daughter cells are formed. The chromosomes and the spindle fibers disperse, and the fiber ring around th...
    • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
      Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continues,...
    • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
      Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    meiotic chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to chromatin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cohesin loading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    sister chromatid cohesion TAS
    Traceable Author Statement
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome TAS
    Traceable Author Statement
    more info
     
    chromosome, centromeric region TAS
    Traceable Author Statement
    more info
     
    cohesin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptonemal complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    wings apart-like protein homolog
    Names
    friend of EBNA2 (Epstein-Barr virus nuclear protein 2)
    friend of EBNA2 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318328.1NP_001305257.1  wings apart-like protein homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AB065003, AK290138, AL844892, BC036507, BC140858, BI438983
      UniProtKB/Swiss-Prot
      Q7Z5K2
      UniProtKB/TrEMBL
      A8K273, B2RTX8
      Conserved Domains (1) summary
      pfam07814
      Location:632992
      WAPL; Wings apart-like protein regulation of heterochromatin
    2. NM_015045.3NP_055860.1  wings apart-like protein homolog isoform 1

      See identical proteins and their annotated locations for NP_055860.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB065003, AK290138, AL844892, BC036507, BC140858, BI438983
      Consensus CDS
      CCDS7375.1
      UniProtKB/Swiss-Prot
      Q7Z5K2
      UniProtKB/TrEMBL
      A8K273, B2RTX8
      Related
      ENSP00000298767.4, OTTHUMP00000020004, ENST00000298767.9, OTTHUMT00000049151
      Conserved Domains (1) summary
      pfam07814
      Location:638998
      WAPL; Wings apart-like protein regulation of heterochromatin

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      86435256..86521816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015979.1XP_016871468.1  wings apart-like protein homolog isoform X2

      Conserved Domains (1) summary
      pfam07814
      Location:593953
      WAPL; Wings apart-like protein regulation of heterochromatin
    2. XM_011539548.1XP_011537850.1  wings apart-like protein homolog isoform X1

      Conserved Domains (1) summary
      pfam07814
      Location:6441004
      WAPL; Wings apart-like protein regulation of heterochromatin
    3. XM_017015980.1XP_016871469.1  wings apart-like protein homolog isoform X3

    4. XM_017015981.1XP_016871470.1  wings apart-like protein homolog isoform X4

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      88476841..88563395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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