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    UBR5 ubiquitin protein ligase E3 component n-recognin 5 [ Homo sapiens (human) ]

    Gene ID: 51366, updated on 9-Jul-2017
    Official Symbol
    UBR5provided by HGNC
    Official Full Name
    ubiquitin protein ligase E3 component n-recognin 5provided by HGNC
    Primary source
    HGNC:HGNC:16806
    See related
    Ensembl:ENSG00000104517 MIM:608413; Vega:OTTHUMG00000164755
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DD5; EDD; HYD; EDD1
    Summary
    This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    8q22.3
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (102252273..102412719, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (103264501..103424947, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ribonucleotide reductase regulatory TP53 inducible subunit M2B Neighboring gene UBR5 antisense RNA 1 Neighboring gene SUMO2 pseudogene 19 Neighboring gene uncharacterized LOC105375683 Neighboring gene RNA, U6atac small nuclear 8, pseudogene Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 14

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of ubiquitin protein ligase E3 component n-recognin 5 (UBR5) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr The interaction of HIV-1 Vpr with the EDVP E3 ligase complex (EDD, DDB1, and VPRBP) promotes Vpr-mediated downregulation of TERT protein PubMed
    vpr The interaction of Vpr with DDB1 facilitates the formation of complexes containing Cul4A-Roc1 E3 ubiquitin ligase. The association of Vpr with DDB1-containing E3 ligase mediates the degradation of UNG2 and SMUG1 PubMed

    Go to the HIV-1, Human Interaction Database

    • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
      Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
    • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
      Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
    • Tryptophan metabolism, organism-specific biosystem (from WikiPathways)
      Tryptophan metabolism, organism-specific biosystem
      Tryptophan metabolism
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ11310, KIAA0896, MGC57263

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    ubiquitin-ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    E3 ubiquitin-protein ligase UBR5
    Names
    E3 identified by differential display
    E3 ubiquitin-protein ligase, HECT domain-containing 1
    HECT-type E3 ubiquitin transferase UBR5
    hyperplastic discs protein homolog
    progestin-induced protein
    NP_001269802.1
    NP_056986.2
    XP_005251019.1
    XP_011515406.2
    XP_011515407.2
    XP_011515408.2
    XP_016869022.1
    XP_016869023.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047152.1 RefSeqGene

      Range
      5001..165417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001282873.1NP_001269802.1  E3 ubiquitin-protein ligase UBR5 isoform 2

      See identical proteins and their annotated locations for NP_001269802.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB020703, AL833555, AP002907, BC037843
      Consensus CDS
      CCDS64946.1
      UniProtKB/Swiss-Prot
      O95071
      Related
      ENSP00000220959.4, OTTHUMP00000227453, ENST00000220959.8, OTTHUMT00000380196
      Conserved Domains (5) summary
      smart00396
      Location:11771244
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:23892452
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:25002795
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00632
      Location:25002798
      HECT; HECT-domain (ubiquitin-transferase)
      pfam11547
      Location:179226
      E3_UbLigase_EDD; E3 ubiquitin ligase EDD
    2. NM_015902.5NP_056986.2  E3 ubiquitin-protein ligase UBR5 isoform 1

      See identical proteins and their annotated locations for NP_056986.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB020703, AP002907, BX489192
      Consensus CDS
      CCDS34933.1
      UniProtKB/Swiss-Prot
      O95071
      Related
      ENSP00000429084.1, OTTHUMP00000227389, ENST00000520539.5, OTTHUMT00000380075
      Conserved Domains (5) summary
      smart00396
      Location:11771244
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:23892452
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:25012796
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00632
      Location:25012799
      HECT; HECT-domain (ubiquitin-transferase)
      pfam11547
      Location:179226
      E3_UbLigase_EDD; E3 ubiquitin ligase EDD

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      102252273..102412719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013534.1XP_016869023.1  E3 ubiquitin-protein ligase UBR5 isoform X4

    2. XM_017013533.1XP_016869022.1  E3 ubiquitin-protein ligase UBR5 isoform X3

    3. XM_011517106.2XP_011515408.2  E3 ubiquitin-protein ligase UBR5 isoform X5

      Related
      ENSP00000427819.1, OTTHUMP00000227455, ENST00000521922.5, OTTHUMT00000380199
    4. XM_011517105.2XP_011515407.2  E3 ubiquitin-protein ligase UBR5 isoform X2

    5. XM_011517104.2XP_011515406.2  E3 ubiquitin-protein ligase UBR5 isoform X1

    6. XM_005250962.4XP_005251019.1  E3 ubiquitin-protein ligase UBR5 isoform X6

      Conserved Domains (4) summary
      smart00396
      Location:187254
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:14011464
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:15131808
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00632
      Location:15131811
      HECT; HECT-domain (ubiquitin-transferase)

    RNA

    1. XR_001745540.1 RNA Sequence

    2. XR_001745539.1 RNA Sequence

    3. XR_001745541.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      103304790..103465221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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