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    Mecp2 methyl CpG binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29386, updated on 8-May-2017
    Official Symbol
    Mecp2provided by RGD
    Official Full Name
    methyl CpG binding protein 2provided by RGD
    Primary source
    RGD:3075
    See related
    Ensembl:ENSRNOG00000056659
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    methyl-CpG-binding protein; binds to DNA that contains a single methyl-CpG pair [RGD, Feb 2006]
    Orthologs
    Location:
    Xq37
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156650389..156713813)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (152390961..152461647)

    Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene transketolase-like 1 Neighboring gene testis expressed 28 Neighboring gene opsin 1 (cone pigments), medium-wave-sensitive Neighboring gene lipoyl synthase, mitochondrial pseudogene Neighboring gene microRNA 5132 Neighboring gene interleukin-1 receptor-associated kinase 1 Neighboring gene host cell factor 1-like

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    core promoter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded methylated DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    double-stranded methylated DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded methylated DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded methylated DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    four-way junction DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    mRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    methyl-CpG binding IEA
    Inferred from Electronic Annotation
    more info
     
    methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    siRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    siRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    unmethylated CpG binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    adult locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    brain development ISO
    Inferred from Sequence Orthology
    more info
     
    cardiolipin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cardiolipin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    catecholamine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    catecholamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular biogenic amine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular biogenic amine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to isoquinoline alkaloid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to potassium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cerebellum development IEA
    Inferred from Electronic Annotation
    more info
     
    cerebellum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cerebellum development ISO
    Inferred from Sequence Orthology
    more info
     
    cerebral cortex development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin silencing IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin silencing ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite development IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    glucocorticoid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glucocorticoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glutamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    heart development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    hippocampus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    histone acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone methylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone methylation ISO
    Inferred from Sequence Orthology
    more info
     
    inositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    inositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    learning ISO
    Inferred from Sequence Orthology
    more info
     
    long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    lung alveolus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    memory ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial electron transport, ubiquinol to cytochrome c IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial electron transport, ubiquinol to cytochrome c ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organismal response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of astrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of histone acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of histone methylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of histone methylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of primary miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of smooth muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    neurological system process involved in regulation of systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    neurological system process involved in regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular process controlling posture ISO
    Inferred from Sequence Orthology
    more info
     
    neuron differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    neuron maturation IEA
    Inferred from Electronic Annotation
    more info
     
    neuron maturation ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    olfactory bulb development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    oligodendrocyte development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    oligodendrocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    pathogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    pathogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylcholine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylcholine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of anterograde dense core granule transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of branching morphogenesis of a nerve IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of histone H3-K9 trimethylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of histone H3-K9 trimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of retrograde dense core granule transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    principal sensory nucleus of trigeminal nerve development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    proprioception IEA
    Inferred from Electronic Annotation
    more info
     
    proprioception ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA methylation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    regulation of DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression by genetic imprinting IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of gene expression by genetic imprinting ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of respiratory gaseous exchange by neurological system process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of respiratory gaseous exchange by neurological system process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    respiratory gaseous exchange IEA
    Inferred from Electronic Annotation
    more info
     
    respiratory gaseous exchange ISO
    Inferred from Sequence Orthology
    more info
     
    response to cocaine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to cocaine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    response to ionizing radiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lead ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    social behavior IEA
    Inferred from Electronic Annotation
    more info
     
    social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    social behavior ISO
    Inferred from Sequence Orthology
    more info
     
    spinal cord development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    startle response IEA
    Inferred from Electronic Annotation
    more info
     
    startle response ISO
    Inferred from Sequence Orthology
    more info
     
    striatum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    thalamus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular system development IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular system development ISO
    Inferred from Sequence Orthology
    more info
     
    visual learning IEA
    Inferred from Electronic Annotation
    more info
     
    visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    gamma-tubulin complex IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with gamma-tubulin complex ISO
    Inferred from Sequence Orthology
    more info
     
    heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    heterochromatin IEA
    Inferred from Electronic Annotation
    more info
     
    heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    methyl-CpG-binding protein 2
    Names
    meCP-2 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022673.2NP_073164.2  methyl-CpG-binding protein 2

      See identical proteins and their annotated locations for NP_073164.2

      Status: PROVISIONAL

      Source sequence(s)
      DQ897369
      UniProtKB/Swiss-Prot
      Q00566
      UniProtKB/TrEMBL
      A0A0G2JWK2
      Conserved Domains (1) summary
      smart00391
      Location:92169
      MBD; Methyl-CpG binding domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

      Range
      156650389..156713813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601935.1XP_017457424.1  methyl-CpG-binding protein 2 isoform X2

    2. XM_006229567.3XP_006229629.1  methyl-CpG-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006229629.1

      UniProtKB/Swiss-Prot
      Q00566
      UniProtKB/TrEMBL
      A0A0G2JWK2
      Related
      ENSRNOP00000069913.1, ENSRNOT00000085723.1
      Conserved Domains (1) summary
      smart00391
      Location:92169
      MBD; Methyl-CpG binding domain
    3. XM_017601936.1XP_017457425.1  methyl-CpG-binding protein 2 isoform X2

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      136055782..136105104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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