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    Foxp2 forkhead box P2 [ Mus musculus (house mouse) ]

    Gene ID: 114142, updated on 11-Apr-2017
    Official Symbol
    Foxp2provided by MGI
    Official Full Name
    forkhead box P2provided by MGI
    Primary source
    MGI:MGI:2148705
    See related
    Ensembl:ENSMUSG00000029563 Vega:OTTMUSG00000022513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAG-16; D0Kist7; AI449000; 2810043D05Rik
    Orthologs
    Location:
    6; 6 A1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (14901349..15441977)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (14851349..15391977)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 3A Neighboring gene predicted gene, 36300 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene predicted gene, 36352 Neighboring gene MyoD family inhibitor domain containing

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryo development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of epithelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of epithelial cell proliferation involved in lung morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of mesenchymal cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    righting reflex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    smooth muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    vocal learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286607.1NP_001273536.1  forkhead box protein P2 isoform 2

      See identical proteins and their annotated locations for NP_001273536.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK042719, AK053022, BC058960, BC062926
      Consensus CDS
      CCDS71726.1
      UniProtKB/Swiss-Prot
      P58463
      Related
      ENSMUSP00000111132.1, OTTMUSP00000025673, ENSMUST00000115472.7, OTTMUST00000053924
      Conserved Domains (2) summary
      cd00059
      Location:482554
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      pfam16159
      Location:320387
      FOXP-CC; FOXP coiled-coil domain
    2. NM_053242.4NP_444472.2  forkhead box protein P2 isoform 1

      See identical proteins and their annotated locations for NP_444472.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK042719, AK053022, AK082361, BC062926, CN526766
      Consensus CDS
      CCDS19918.1
      UniProtKB/Swiss-Prot
      P58463
      Related
      ENSMUSP00000111137.1, ENSMUST00000115477.7
      Conserved Domains (2) summary
      cd00059
      Location:503575
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      pfam16159
      Location:341408
      FOXP-CC; FOXP coiled-coil domain
    3. NM_212435.1NP_997600.1  forkhead box protein P2 isoform 1

      See identical proteins and their annotated locations for NP_997600.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK042719, AK053022, BC062926
      Consensus CDS
      CCDS19918.1
      UniProtKB/Swiss-Prot
      P58463
      Related
      ENSMUSP00000031545.7, OTTMUSP00000025660, ENSMUST00000031545.13, OTTMUST00000053902
      Conserved Domains (2) summary
      cd00059
      Location:503575
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      pfam16159
      Location:341408
      FOXP-CC; FOXP coiled-coil domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      14901349..15441977
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321341.1XP_017176830.1  forkhead box protein P2 isoform X1

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