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    UBP6 ubiquitin-specific protease UBP6 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 850562, updated on 5-Mar-2017
    Gene symbol
    UBP6
    Gene description
    ubiquitin-specific protease UBP6
    Primary source
    SGD:S000001906
    Locus tag
    YFR010W
    Gene type
    protein coding
    RNA name
    ubiquitin-specific protease UBP6
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See UBP6 in Map Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (165067..166566)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene putative AAA family ATPase GCN20 Neighboring gene Mic19p Neighboring gene tRNA

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    thiol-dependent ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thiol-dependent ubiquitinyl hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    protein deubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    proteasome complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    proteasome regulatory particle IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Names
    ubiquitin-specific protease UBP6
    NP_116665.1
    • Ubiquitin-specific protease; situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains en bloc, rather than from the distal tip of the chain; negatively regulates degradation of ubiquitinated proteins by the proteasome; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance; human homolog UBP14 complements yeast null mutant

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      165067..166566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179975.1NP_116665.1  TPA: ubiquitin-specific protease UBP6 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_116665.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P43593
      Conserved Domains (4) summary
      smart00213
      Location:676
      UBQ; Ubiquitin homologues
      cd02657
      Location:110495
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      pfam00443
      Location:108494
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl00155
      Location:1076
      UBQ; Ubiquitin-like proteins
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