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    DYNLT1 dynein light chain Tctex-type 1 [ Homo sapiens (human) ]

    Gene ID: 6993, updated on 6-Aug-2017
    Official Symbol
    DYNLT1provided by HGNC
    Official Full Name
    dynein light chain Tctex-type 1provided by HGNC
    Primary source
    HGNC:HGNC:11697
    See related
    Ensembl:ENSG00000146425 MIM:601554; Vega:OTTHUMG00000015918
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CW-1; TCTEL1; tctex-1
    Summary
    This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
    Orthologs
    Location:
    6q25.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (158636474..158644786, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (159057506..159065804, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene calcyclin binding protein pseudogene 3 Neighboring gene transmembrane protein 181 Neighboring gene TatD DNase domain containing 2 pseudogene 2 Neighboring gene microRNA 7161 Neighboring gene synaptotagmin like 3 Neighboring gene archaelysin family metallopeptidase 2 pseudogene 2 Neighboring gene microRNA 3918

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC111571

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of mitotic spindle orientation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular transport of viral protein in host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule-dependent intracellular transport of viral material towards nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron projection morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    regulation of G-protein coupled receptor protein signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic dynein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    host cell IEA
    Inferred from Electronic Annotation
    more info
     
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    secretory vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    dynein light chain Tctex-type 1
    Names
    T-complex testis-specific protein 1 homolog
    t-complex-associated-testis-expressed 1-like 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291602.1NP_001278531.1  dynein light chain Tctex-type 1 isoform 2

      See identical proteins and their annotated locations for NP_001278531.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BU675683, HY017024, HY171700
      Conserved Domains (1) summary
      pfam03645
      Location:597
      Tctex-1; Tctex-1 family
    2. NM_001291603.1NP_001278532.1  dynein light chain Tctex-type 1 isoform 3

      See identical proteins and their annotated locations for NP_001278532.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL589931, AL591025, BU675683, DN915418, HY017024, HY171700
      Conserved Domains (1) summary
      pfam03645
      Location:1664
      Tctex-1; Tctex-1 family
    3. NM_006519.3NP_006510.1  dynein light chain Tctex-type 1 isoform 1

      See identical proteins and their annotated locations for NP_006510.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL589931, BC105588, BU675683, HY171700
      Consensus CDS
      CCDS5257.1
      UniProtKB/Swiss-Prot
      P63172
      Related
      ENSP00000356056.3, OTTHUMP00000017508, ENST00000367089.7, OTTHUMT00000042881
      Conserved Domains (1) summary
      pfam03645
      Location:16111
      Tctex-1; Tctex-1 family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      158636474..158644786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      159320069..159328379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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