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    Trem2 triggering receptor expressed on myeloid cells 2 [ Mus musculus (house mouse) ]

    Gene ID: 83433, updated on 22-Apr-2017
    Official Symbol
    Trem2provided by MGI
    Official Full Name
    triggering receptor expressed on myeloid cells 2provided by MGI
    Primary source
    MGI:MGI:1913150
    See related
    Ensembl:ENSMUSG00000023992 Vega:OTTMUSG00000021045
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TREM-2; Trem2a; Trem2b; Trem2c
    Summary
    The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
    Orthologs
    Location:
    17; 17 C
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (48346401..48352276)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (48485726..48491598)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene triggering receptor expressed on myeloid cells-like 2 Neighboring gene RIKEN cDNA B430306N03 gene Neighboring gene triggering receptor expressed on myeloid cells-like 1 Neighboring gene nuclear transcription factor-Y alpha

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipoteichoic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to lipoteichoic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to peptidoglycan IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    detection of lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    detection of lipoteichoic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    detection of peptidoglycan IDA
    Inferred from Direct Assay
    more info
    PubMed 
    innate immune response IC
    Inferred by Curator
    more info
    PubMed 
    lipopolysaccharide-mediated signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    phagocytosis, engulfment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of C-C chemokine receptor CCR7 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of CD40 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of antigen processing and presentation of peptide antigen via MHC class II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    triggering receptor expressed on myeloid cells 2
    Names
    triggering receptor expressed on monocytes 2
    triggering receptor expressed on myeloid cells 2a
    triggering receptor expressed on myeloid cells 2b
    triggering receptor expressed on myeloid cells 2c

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272078.1NP_001259007.1  triggering receptor expressed on myeloid cells 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001259007.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus that lacks a transmembrane domain, compared to isoform 1.
      Source sequence(s)
      AC166164, AK039477, AY187009, BY541740
      Consensus CDS
      CCDS70825.1
      UniProtKB/Swiss-Prot
      Q99NH8
      Related
      ENSMUSP00000108863.3, OTTMUSP00000023120, ENSMUST00000113237.3, OTTMUST00000049782
      Conserved Domains (1) summary
      cl11960
      Location:23128
      Ig; Immunoglobulin domain
    2. NM_031254.3NP_112544.1  triggering receptor expressed on myeloid cells 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_112544.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC166164, AK039477, BY541740
      Consensus CDS
      CCDS28865.1
      UniProtKB/Swiss-Prot
      Q99NH8
      Related
      ENSMUSP00000024791.8, OTTMUSP00000023119, ENSMUST00000024791.14, OTTMUST00000049781
      Conserved Domains (2) summary
      smart00410
      Location:23111
      IG_like; Immunoglobulin like
      cl11960
      Location:23128
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      48346401..48352276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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