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    Kcnu1 potassium channel, subfamily U, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 16532, updated on 25-May-2017
    Official Symbol
    Kcnu1provided by MGI
    Official Full Name
    potassium channel, subfamily U, member 1provided by MGI
    Primary source
    MGI:MGI:1202300
    See related
    Ensembl:ENSMUSG00000031576 Vega:OTTMUSG00000031857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Slo3; mSlo3; Kcnma3
    Orthologs
    Location:
    8; 8 A2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (25848627..25937943)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (26960095..27048406)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene steroidogenic acute regulatory protein Neighboring gene ash2 (absent, small, or homeotic)-like (Drosophila) Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase Neighboring gene protein-O-mannose kinase Neighboring gene predicted gene, 31402

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Fertilization, organism-specific biosystem (from REACTOME)
      Fertilization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Insulin secretion, organism-specific biosystem (from KEGG)
      Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
    • Reproduction, organism-specific biosystem (from REACTOME)
      Reproduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Sperm Motility And Taxes, organism-specific biosystem (from REACTOME)
      Sperm Motility And Taxes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    large conductance calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    potassium channel subfamily U member 1
    Names
    KSper
    calcium-activated potassium channel subunit alpha-3
    calcium-activated potassium channel, subfamily M subunit alpha-3
    pH-sensitive maxi potassium channel
    pore-forming subunit of the sperm-specific alkalization activated K(+) current
    potassium large conductance pH-sensitive channel, subfamily M, alpha member 3
    slowpoke homolog 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008432.3NP_032458.3  potassium channel subfamily U member 1

      See identical proteins and their annotated locations for NP_032458.3

      Status: VALIDATED

      Source sequence(s)
      AF039213, BQ175543, CJ042506
      Consensus CDS
      CCDS52530.1
      UniProtKB/Swiss-Prot
      O54982
      UniProtKB/TrEMBL
      G3X9P7
      Related
      ENSMUSP00000096457.3, OTTMUSP00000042086, ENSMUST00000098858.10, OTTMUST00000078991
      Conserved Domains (3) summary
      pfam00520
      Location:133323
      Ion_trans; Ion transport protein
      pfam03493
      Location:469557
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:230316
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      25848627..25937943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312583.1XP_017168072.1  potassium channel subfamily U member 1 isoform X4

      Conserved Domains (3) summary
      pfam00520
      Location:41241
      Ion_trans; Ion transport protein
      pfam03493
      Location:387475
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:179234
      Ion_trans_2; Ion channel
    2. XM_006509024.2XP_006509087.1  potassium channel subfamily U member 1 isoform X1

      Conserved Domains (3) summary
      pfam00520
      Location:133333
      Ion_trans; Ion transport protein
      pfam03493
      Location:479567
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:271326
      Ion_trans_2; Ion channel
    3. XM_017312582.1XP_017168071.1  potassium channel subfamily U member 1 isoform X3

    4. XM_017312581.1XP_017168070.1  potassium channel subfamily U member 1 isoform X2

    5. XM_017312584.1XP_017168073.1  potassium channel subfamily U member 1 isoform X5

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