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    SERPINB2 serpin family B member 2 [ Homo sapiens (human) ]

    Gene ID: 5055, updated on 22-Apr-2017
    Official Symbol
    SERPINB2provided by HGNC
    Official Full Name
    serpin family B member 2provided by HGNC
    Primary source
    HGNC:HGNC:8584
    See related
    Ensembl:ENSG00000197632 MIM:173390; Vega:OTTHUMG00000060592
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAI; PAI2; PAI-2; PLANH2; HsT1201
    Orthologs
    Location:
    18q21.33-q22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 18 NC_000018.10 (63887705..63903890)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (61554939..61571124)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene serpin family B member 11 (gene/pseudogene) Neighboring gene serpin family B member 7 Neighboring gene serpin family B member 10 Neighboring gene uncharacterized LOC105372165 Neighboring gene histocompatibility minor serpin domain containing

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of serpin peptidase inhibitor, clade B, member 2 (SERPINB2) in human B cells PubMed
    env HIV-1 infection and HIV-1 gp120 treatment of human peripheral blood mononuclear cells result in induction of SerpinB2 and this induction enhances transcription from the HIV-1 LTR PubMed
    Tat tat HIV-1 Tat upregulates the expression of serpin peptidase inhibitor, clade B, member 2 (SERPINB2) in human primary T cells PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of serpin peptidase inhibitor, clade B2 (SERPINB2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    • Aryl Hydrocarbon Receptor Pathway, organism-specific biosystem (from WikiPathways)
      Aryl Hydrocarbon Receptor Pathway, organism-specific biosystemThe aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic m...
    • Blood Clotting Cascade, organism-specific biosystem (from WikiPathways)
      Blood Clotting Cascade, organism-specific biosystemCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered ...
    • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
      Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
    • Complement and coagulation cascades, conserved biosystem (from KEGG)
      Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
    • Dissolution of Fibrin Clot, organism-specific biosystem (from REACTOME)
      Dissolution of Fibrin Clot, organism-specific biosystemThe crosslinked fibrin multimers in a clot are broken down to soluble polypeptides by plasmin, a serine protease. Plasmin can be generated from its inactive precursor plasminogen and recruited to the...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    serine-type endopeptidase inhibitor activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    fibrinolysis TAS
    Traceable Author Statement
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    plasminogen activator inhibitor 2
    Names
    monocyte Arg-serpin
    placental plasminogen activator inhibitor
    plasminogen activator inhibitor, type II (arginine-serpin)
    serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
    serpin B2
    serpin peptidase inhibitor, clade B (ovalbumin), member 2
    urokinase inhibitor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143818.1NP_001137290.1  plasminogen activator inhibitor 2

      See identical proteins and their annotated locations for NP_001137290.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC072051, CD366374, DA543366, DQ656059
      Consensus CDS
      CCDS11989.1
      UniProtKB/Swiss-Prot
      P05120
      Related
      ENSP00000401645.1, ENST00000457692.5
      Conserved Domains (1) summary
      cd02058
      Location:4415
      PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...
    2. NM_002575.2NP_002566.1  plasminogen activator inhibitor 2

      See identical proteins and their annotated locations for NP_002566.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC072051, BC012609, CD366374
      Consensus CDS
      CCDS11989.1
      UniProtKB/Swiss-Prot
      P05120
      Related
      ENSP00000299502.4, OTTHUMP00000066997, ENST00000299502.8, OTTHUMT00000134009
      Conserved Domains (1) summary
      cd02058
      Location:4415
      PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p7 Primary Assembly

      Range
      63887705..63903890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018929.2 Alternate CHM1_1.1

      Range
      61551138..61567323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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