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    HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 [ Homo sapiens (human) ]

    Gene ID: 3181, updated on 9-Jul-2017
    Official Symbol
    HNRNPA2B1provided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein A2/B1provided by HGNC
    Primary source
    HGNC:HGNC:5033
    See related
    Ensembl:ENSG00000122566 MIM:600124; Vega:OTTHUMG00000023471
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNPA2; HNRPA2; HNRPB1; SNRPB1; HNRNPA2; HNRNPB1; IBMPFD2; HNRPA2B1
    Summary
    This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    7p15.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (26189927..26200793, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (26229547..26240413, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375199 Neighboring gene uncharacterized LOC105375198 Neighboring gene nuclear factor, erythroid 2 like 3 Neighboring gene chromobox 3 Neighboring gene ribosomal protein L23 pseudogene 7

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    env Depletion of hnRNP A1 and A2 increase expression of viral structural proteins Gag, Env, and gp120 PubMed
    Envelope surface glycoprotein gp160, precursor env Depletion of hnRNP A1 and A2 increase expression of viral structural proteins Gag, Env, and gp120 PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    gag Depletion of hnRNP A1 and A2 increase expression of viral structural proteins Gag, Env, and gp120 PubMed
    Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa. The interaction of Rev with HNRNPA2B1 is increased by RRE PubMed
    Tat tat Expression of HIV-1 Tat downregulates the abundance of heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) in the nucleoli of Jurkat T-cells PubMed
    Vif vif Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G13-2: AGGGA) to regulate the levels of vif and vpr mRNA, and the amounts of Vif and Vpr protein expression PubMed
    vif Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G12-1: AGGGA) to regulate the levels of vif mRNA and Vif protein expression PubMed
    Vpr vpr Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G13-2: AGGGA) to regulate the levels of vif and vpr mRNA, and the amounts of Vif and Vpr protein expression PubMed
    integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies translation regulatory and RNA binding proteins eIF3h, eEF1A-1, and hnRNPA2 as IN-binding partners PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) at amino acid residues 135-136 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • mRNA Processing, organism-specific biosystem (from WikiPathways)
      mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ22720, DKFZp779B0244

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-rich strand telomeric DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    N6-methyladenosine-containing RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pre-mRNA intronic binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    single-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    G-quadruplex DNA unwinding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    RNA metabolic process TAS
    Traceable Author Statement
    more info
     
    RNA transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-12-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    mRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    miRNA transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of telomerase RNA reverse transcriptase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of telomere maintenance via telomere lengthening ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    primary miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Cajal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome, telomeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome TAS
    Traceable Author Statement
    more info
     
    intracellular ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    heterogeneous nuclear ribonucleoproteins A2/B1
    Names
    hnRNP A2 / hnRNP B1
    nuclear ribonucleoprotein particle A2 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029680.1 RefSeqGene

      Range
      5001..15858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002137.3NP_002128.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2

      See identical proteins and their annotated locations for NP_002128.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A2) lacks 36 bases at the beginning of the coding region compared to variant B1. The N-terminus of isoform A2 is thus different from isoform B1. This isoform (A2) is the predominant protein.
      Source sequence(s)
      AC004520, DB244417, M29065
      Consensus CDS
      CCDS5397.1
      UniProtKB/Swiss-Prot
      P22626
      Related
      ENSP00000349101.7, OTTHUMP00000122512, ENST00000356674.7, OTTHUMT00000214110
      Conserved Domains (3) summary
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      pfam11627
      Location:290315
      HnRNPA1; Nuclear factor hnRNPA1
    2. NM_031243.2NP_112533.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform B1

      See identical proteins and their annotated locations for NP_112533.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B1) contains an additional 36 bases compared to variant A2. This additional region affects only the beginning of the coding region. The N-terminus of isoform B1 is thus different from isoform A2.
      Source sequence(s)
      AC004520, DB244417, M29064
      Consensus CDS
      CCDS43557.1
      UniProtKB/Swiss-Prot
      P22626
      Related
      ENSP00000346694.4, OTTHUMP00000122511, ENST00000354667.8, OTTHUMT00000214109
      Conserved Domains (3) summary
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      pfam11627
      Location:302327
      HnRNPA1; Nuclear factor hnRNPA1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      26189927..26200793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012110.1XP_016867599.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

      UniProtKB/Swiss-Prot
      P22626
      Conserved Domains (3) summary
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      pfam11627
      Location:290315
      HnRNPA1; Nuclear factor hnRNPA1
    2. XM_017012109.1XP_016867598.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

      UniProtKB/Swiss-Prot
      P22626
      Conserved Domains (3) summary
      cd12581
      Location:100179
      RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:787
      RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      pfam11627
      Location:290315
      HnRNPA1; Nuclear factor hnRNPA1
    3. XM_005249729.1XP_005249786.1  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

      See identical proteins and their annotated locations for XP_005249786.1

      UniProtKB/Swiss-Prot
      P22626
      Related
      ENSP00000354021.4, OTTHUMP00000202466, ENST00000360787.8, OTTHUMT00000327981
      Conserved Domains (3) summary
      cd12581
      Location:112191
      RRM2_hnRNPA2B1; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      cd12762
      Location:1999
      RRM1_hnRNPA2B1; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
      pfam11627
      Location:302327
      HnRNPA1; Nuclear factor hnRNPA1

    RNA

    1. XR_001744673.1 RNA Sequence

    2. XR_001744671.1 RNA Sequence

    3. XR_001744674.1 RNA Sequence

    4. XR_001744672.1 RNA Sequence

    5. XR_001744670.1 RNA Sequence

    6. XR_001744675.1 RNA Sequence

    7. XR_242077.1 RNA Sequence

    8. XR_242076.1 RNA Sequence

    9. XR_428077.1 RNA Sequence

    10. XR_001744666.1 RNA Sequence

    11. XR_001744665.1 RNA Sequence

    12. XR_001744668.1 RNA Sequence

    13. XR_001744667.1 RNA Sequence

    14. XR_001744663.1 RNA Sequence

    15. XR_001744664.1 RNA Sequence

    16. XR_001744662.1 RNA Sequence

    17. XR_001744669.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      26222782..26233627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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