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    Cnr1 cannabinoid receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25248, updated on 5-Dec-2017
    Official Symbol
    Cnr1provided by RGD
    Official Full Name
    cannabinoid receptor 1provided by RGD
    Primary source
    RGD:2369
    See related
    Ensembl:ENSRNOG00000008223
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SKR6R
    Summary
    G-protein coupled receptor for psychoactive cannabinoids; may mediate inhibition of NO production and participate in retrograde signaling by endocannabinoids [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 374.6), Adrenal (RPKM 99.1) and 2 other tissues See more
    Orthologs
    Location:
    5q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (49307584..49333064)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (53878619..53904013)

    Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene similar to BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP2 isoform beta Neighboring gene uncharacterized LOC108350950 Neighboring gene uncharacterized LOC103692331 Neighboring gene sperm acrosome associated 1

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    cannabinoid receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cannabinoid receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    drug binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenylate cyclase-modulating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    adenylate cyclase-modulating G-protein coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonal fasciculation IEA
    Inferred from Electronic Annotation
    more info
     
    axonal fasciculation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cannabinoid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cannabinoid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maternal process involved in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    memory IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of mast cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of nitric-oxide synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of acute inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fever generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of penile erection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic transmission, GABAergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to morphine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    trans-synaptic signaling by endocannabinoid, modulating synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    cannabinoid receptor 1
    Names
    CB-R
    CB1
    brain-type cannabinoid receptor
    cannabinoid receptor 1 (brain)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012784.4NP_036916.1  cannabinoid receptor 1

      See identical proteins and their annotated locations for NP_036916.1

      Status: PROVISIONAL

      Source sequence(s)
      X55812
      UniProtKB/Swiss-Prot
      P20272
      Related
      ENSRNOP00000010850.1, ENSRNOT00000010850.2
      Conserved Domains (1) summary
      cd15340
      Location:118409
      7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

      Range
      49307584..49333064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593151.1XP_017448640.1  cannabinoid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      P20272
      Conserved Domains (1) summary
      cd15340
      Location:118409
      7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_006237984.3XP_006238046.1  cannabinoid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006238046.1

      UniProtKB/Swiss-Prot
      P20272
      Conserved Domains (1) summary
      cd15340
      Location:118409
      7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate Rn_Celera

    Genomic

    1. AC_000073.1 Alternate Rn_Celera

      Range
      47168709..47190724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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