Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    RAB11FIP2 RAB11 family interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 22841, updated on 22-Apr-2017
    Official Symbol
    RAB11FIP2provided by HGNC
    Official Full Name
    RAB11 family interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:29152
    See related
    Ensembl:ENSG00000107560 MIM:608599; Vega:OTTHUMG00000019128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    nRip11; Rab11-FIP2
    Orthologs
    Location:
    10q26.11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (118004916..118046921, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (119764427..119806297, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724627 Neighboring gene uncharacterized LOC105378504 Neighboring gene cancer susceptibility 2 (non-protein coding) Neighboring gene uncharacterized LOC101927760 Neighboring gene uncharacterized LOC105378506

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
    NHGRI GWA Catalog
    Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
    NHGRI GWA Catalog
    Genome-wide interaction studies reveal sex-specific asthma risk alleles.
    NHGRI GWA Catalog
    • Aquaporin-mediated transport, organism-specific biosystem (from REACTOME)
      Aquaporin-mediated transport, organism-specific biosystemAquaporins (AQP's) are six-pass transmembrane proteins that form channels in membranes. Each monomer contains a central channel formed in part by two asparagine-proline-alanine motifs (NPA boxes) tha...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • Vasopressin regulates renal water homeostasis via Aquaporins, organism-specific biosystem (from REACTOME)
      Vasopressin regulates renal water homeostasis via Aquaporins, organism-specific biosystemIn the kidney water and solutes are passed out of the bloodstream and into the proximal tubule via the slit-like structure formed by nephrin in the glomerulus. Water is reabsorbed from the filtrate d...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0941

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Rab GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin secretion involved in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulated exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    renal water homeostasis TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasmic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    rab11 family-interacting protein 2
    Names
    RAB11 family interacting protein 2 (class I)
    RAB11-FIP2 long isoform

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330167.1NP_001317096.1  rab11 family-interacting protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022395, DQ013303, R52658
      Consensus CDS
      CCDS81512.1
      UniProtKB/Swiss-Prot
      Q7L804
      Conserved Domains (2) summary
      cd08682
      Location:15141
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:472519
      RBD-FIP; FIP domain
    2. NM_014904.2NP_055719.1  rab11 family-interacting protein 2 isoform 1

      See identical proteins and their annotated locations for NP_055719.1

      Status: VALIDATED

      Source sequence(s)
      AB023158, AC022395, BM975322
      Consensus CDS
      CCDS7602.1
      UniProtKB/Swiss-Prot
      Q7L804
      Related
      ENSP00000347839.3, OTTHUMP00000020579, ENST00000355624.7, OTTHUMT00000050583
      Conserved Domains (2) summary
      cd08682
      Location:15141
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:452499
      RBD-FIP; FIP domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      118004916..118046921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005269629.3XP_005269686.1  rab11 family-interacting protein 2 isoform X1

      Related
      ENSP00000358200.3, ENST00000369199.4
      Conserved Domains (2) summary
      cd08682
      Location:15141
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:472519
      RBD-FIP; FIP domain
    2. XM_017015926.1XP_016871415.1  rab11 family-interacting protein 2 isoform X2

      Conserved Domains (1) summary
      cd08682
      Location:15141
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      120048435..120090122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center