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    CDC13 telomere-binding protein CDC13 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851306, updated on 9-Jul-2017
    Gene symbol
    CDC13
    Gene description
    telomere-binding protein CDC13
    Primary source
    SGD:S000002379
    Locus tag
    YDL220C
    Gene type
    protein coding
    RNA name
    telomere-binding protein CDC13
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    EST4
    See CDC13 in Map Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (62244..65018, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Hbt1p Neighboring gene Fmp45p Neighboring gene D-tyrosyl-tRNA(Tyr) deacylase Neighboring gene hypothetical protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    G-rich strand telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    single-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    single-stranded telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    single-stranded telomeric DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telomerase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of telomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of telomere maintenance via telomerase IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ribonucleoprotein complex localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telomere capping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telomere maintenance via telomerase IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    CST complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    telomere-binding protein CDC13
    NP_010061.1
    • Single stranded DNA-binding protein found at TG1-3 telomere G-tails; key roles in regulation of telomerase, telomere end protection, conventional telomere replication; regulates telomere replication through recruitment of specific sub-complexes, essential function is telomere capping; forms homodimer via N-terminus; disruption of dimerization leads to short telomeres; autophagy and proteasome are involved in Cdc13p degradation; differentially phosphorylated through cell cycle

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      62244..65018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180280.1NP_010061.1  TPA: telomere-binding protein CDC13 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010061.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P32797
      Conserved Domains (2) summary
      smart00976
      Location:510665
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      pfam16853
      Location:14241
      CDC13_N; Cell division control protein 13 N-terminus
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