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    MYLK myosin light chain kinase [ Homo sapiens (human) ]

    Gene ID: 4638, updated on 20-Apr-2017
    Official Symbol
    MYLKprovided by HGNC
    Official Full Name
    myosin light chain kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:7590
    See related
    Ensembl:ENSG00000065534 MIM:600922; Vega:OTTHUMG00000141304
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KRP; AAT7; MLCK; MLCK1; MYLK1; smMLCK; MLCK108; MLCK210; MSTP083
    Summary
    This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    3q21.1
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (123612296..123884302, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (123331143..123603149, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 5 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene MYLK antisense RNA 1 Neighboring gene uncharacterized LOC105369194 Neighboring gene MYLK antisense RNA 2 Neighboring gene coiled-coil domain containing 14 Neighboring gene rhophilin associated tail protein 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Professional guidelines

    Description
    Professional guideline
    ACMG 2013

    The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in MYLK that are pathogenic or expected to be pathogenic.

    GuidelinePubMed

    Associated conditions

    Description Tests
    Aortic aneurysm, familial thoracic 7 Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated (2016-01-14)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated (2016-01-14)

    ClinGen Genome Curation PagePubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat in combination with morphine activates myosin light chain kinase expression in primary brain micro vascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Apelin signaling pathway, organism-specific biosystem (from KEGG)
      Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
    • Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystem (from WikiPathways)
      Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystemThis pathway is based on Figure 8 of "Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome."(See bibliography). These 3 pathways demonstr...
    • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora B signaling, organism-specific biosystem
      Aurora B signaling
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Endothelin Pathways, organism-specific biosystem (from WikiPathways)
      Endothelin Pathways, organism-specific biosystemEndothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of i...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Gastric acid secretion, organism-specific biosystem (from KEGG)
      Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
    • Gastric acid secretion, conserved biosystem (from KEGG)
      Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
    • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
      Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Oxytocin signaling pathway, conserved biosystem (from KEGG)
      Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Platelet activation, organism-specific biosystem (from KEGG)
      Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases activate PAKs, organism-specific biosystem (from REACTOME)
      RHO GTPases activate PAKs, organism-specific biosystemThe PAKs (p21-activated kinases) are a family of serine/threonine kinases mainly implicated in cytoskeletal rearrangements. All PAKs share a conserved catalytic domain located at the carboxyl terminu...
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
      Smooth Muscle Contraction, organism-specific biosystemLayers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac ...
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ12216, DKFZp686I10125

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    myosin light chain kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    aorta smooth muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bleb assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular hypotonic response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    muscle contraction TAS
    Traceable Author Statement
    more info
     
    positive regulation of calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of wound healing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    smooth muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    tonic smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    myosin light chain kinase, smooth muscle
    Names
    kinase-related protein
    myosin, light polypeptide kinase
    smooth muscle myosin light chain kinase
    telokin
    NP_001308238.1
    NP_444253.3
    NP_444254.3
    NP_444255.3
    NP_444256.3
    NP_444259.1
    NP_444260.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029111.1 RefSeqGene

      Range
      5001..277007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001321309.1NP_001308238.1  myosin light chain kinase, smooth muscle isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC020634, AC117381, AY339601, BC064695, BC113458, BQ006428, DA853780, U48959
      UniProtKB/Swiss-Prot
      Q15746
      UniProtKB/TrEMBL
      Q05B97
      Conserved Domains (9) summary
      cd00096
      Location:464533
      Ig; Immunoglobulin domain
      cd05762
      Location:10621159
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:16461713
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:11551247
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:16331723
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:12851543
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam00069
      Location:12881543
      Pkinase; Protein kinase domain
      pfam16620
      Location:75236
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:548633
      Ig; Immunoglobulin domain
    2. NM_053025.3NP_444253.3  myosin light chain kinase, smooth muscle isoform 1

      See identical proteins and their annotated locations for NP_444253.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the full-length transcript and encodes the full-length nonmuscle isoform.
      Source sequence(s)
      AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
      Consensus CDS
      CCDS46896.1
      UniProtKB/Swiss-Prot
      Q15746
      Related
      ENSP00000353452.3, ENST00000360304.7
      Conserved Domains (9) summary
      cd00096
      Location:640709
      Ig; Immunoglobulin domain
      cd05762
      Location:12381335
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:18221889
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:13311423
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:18091899
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:14611719
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam00069
      Location:14641719
      Pkinase; Protein kinase domain
      pfam16620
      Location:251412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:724809
      Ig; Immunoglobulin domain
    3. NM_053026.3NP_444254.3  myosin light chain kinase, smooth muscle isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) does not utilize exon 11, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
      Consensus CDS
      CCDS43141.1
      UniProtKB/Swiss-Prot
      Q15746
      Related
      ENSP00000320622.5, OTTHUMP00000180643, ENST00000346322.9, OTTHUMT00000280601
      Conserved Domains (9) summary
      cd00096
      Location:571640
      Ig; Immunoglobulin domain
      cd05762
      Location:11691266
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:17531820
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:12621354
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:17401830
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:13921650
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam00069
      Location:13951650
      Pkinase; Protein kinase domain
      pfam16620
      Location:251412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:655740
      Ig; Immunoglobulin domain
    4. NM_053027.3NP_444255.3  myosin light chain kinase, smooth muscle isoform 3A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3A) does not utilize exon 30, compared to variant 1, resulting in a shorter protein (isoform 3A), compared to isoform 1.
      Source sequence(s)
      AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
      Consensus CDS
      CCDS3023.1
      UniProtKB/Swiss-Prot
      Q15746
      Related
      ENSP00000352088.1, ENST00000359169.5
      Conserved Domains (9) summary
      cd00096
      Location:640709
      Ig; Immunoglobulin domain
      cd05762
      Location:12381335
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:17711838
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:13311423
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:17581848
      I-set; Immunoglobulin I-set domain
      pfam00069
      Location:14641668
      Pkinase; Protein kinase domain
      pfam16620
      Location:251412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:724809
      Ig; Immunoglobulin domain
      cl21453
      Location:14611668
      PKc_like; Protein Kinases, catalytic domain
    5. NM_053028.3NP_444256.3  myosin light chain kinase, smooth muscle isoform 3B

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3B) does not utilize exons 11 and 30, compared to variant 1, resulting in a shorter protein (isoform 3B), compared to isoform 1.
      Source sequence(s)
      AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
      UniProtKB/Swiss-Prot
      Q15746
      Conserved Domains (9) summary
      cd00096
      Location:571640
      Ig; Immunoglobulin domain
      cd05762
      Location:11691266
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:17021769
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:12621354
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:16891779
      I-set; Immunoglobulin I-set domain
      pfam00069
      Location:13951599
      Pkinase; Protein kinase domain
      pfam16620
      Location:251412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:655740
      Ig; Immunoglobulin domain
      cl21453
      Location:13921599
      PKc_like; Protein Kinases, catalytic domain
    6. NM_053031.3NP_444259.1  myosin light chain kinase, smooth muscle isoform 7

      See identical proteins and their annotated locations for NP_444259.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes the shorter isoform of kinase related protein, telokin. The first exon corresponds to intron 30 and the remainder of the transcript corresponds to the last two exons of the gene. It is shorter than variant 8 by one codon at the splicing junction between the first two exons.
      Source sequence(s)
      BC064420, BC113458, DB016380
      Consensus CDS
      CCDS58849.1
      UniProtKB/Swiss-Prot
      Q15746
      UniProtKB/TrEMBL
      Q05B97
      Related
      ENSP00000463691.1, OTTHUMP00000260374, ENST00000578202.1, OTTHUMT00000444083
      Conserved Domains (2) summary
      smart00408
      Location:61128
      IGc2; Immunoglobulin C-2 Type
      pfam07679
      Location:48138
      I-set; Immunoglobulin I-set domain
    7. NM_053032.3NP_444260.1  myosin light chain kinase, smooth muscle isoform 8

      See identical proteins and their annotated locations for NP_444260.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) encodes the longer isoform of kinase related protein, telokin. It is longer than variant 7 by one codon at the splicing junction between the first two exons.
      Source sequence(s)
      BC064420, BC113456, DB016380
      Consensus CDS
      CCDS46897.1
      UniProtKB/Swiss-Prot
      Q15746
      UniProtKB/TrEMBL
      Q05B98
      Related
      ENSP00000428967.1, OTTHUMP00000225212, ENST00000418370.6, OTTHUMT00000358552
      Conserved Domains (2) summary
      smart00408
      Location:62129
      IGc2; Immunoglobulin C-2 Type
      pfam07679
      Location:49139
      I-set; Immunoglobulin I-set domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      123612296..123884302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006472.1XP_016861961.1  myosin light chain kinase, smooth muscle isoform X6

      UniProtKB/Swiss-Prot
      Q15746
      Related
      ENSP00000462118.1, OTTHUMP00000260375, ENST00000583087.5, OTTHUMT00000444084
      Conserved Domains (2) summary
      smart00408
      Location:62129
      IGc2; Immunoglobulin C-2 Type
      pfam07679
      Location:49139
      I-set; Immunoglobulin I-set domain
    2. XM_017006473.1XP_016861962.1  myosin light chain kinase, smooth muscle isoform X7

      UniProtKB/Swiss-Prot
      Q15746
      Conserved Domains (2) summary
      smart00408
      Location:61128
      IGc2; Immunoglobulin C-2 Type
      pfam07679
      Location:48138
      I-set; Immunoglobulin I-set domain
    3. XM_017006469.1XP_016861958.1  myosin light chain kinase, smooth muscle isoform X3

      UniProtKB/Swiss-Prot
      Q15746
    4. XM_017006471.1XP_016861960.1  myosin light chain kinase, smooth muscle isoform X5

      UniProtKB/Swiss-Prot
      Q15746
      Conserved Domains (6) summary
      cd05762
      Location:38135
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:622689
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:131223
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:609699
      I-set; Immunoglobulin I-set domain
      pfam00069
      Location:264519
      Pkinase; Protein kinase domain
      cl21453
      Location:261519
      PKc_like; Protein Kinases, catalytic domain
    5. XM_017006470.1XP_016861959.1  myosin light chain kinase, smooth muscle isoform X4

    6. XM_011512861.2XP_011511163.1  myosin light chain kinase, smooth muscle isoform X2

      Conserved Domains (9) summary
      cd00096
      Location:640709
      Ig; Immunoglobulin domain
      cd05762
      Location:12381335
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:17541821
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:13311423
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:17411831
      I-set; Immunoglobulin I-set domain
      pfam00069
      Location:14731651
      Pkinase; Protein kinase domain
      pfam16620
      Location:251412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:724809
      Ig; Immunoglobulin domain
      cl21453
      Location:14731651
      PKc_like; Protein Kinases, catalytic domain
    7. XM_011512860.2XP_011511162.1  myosin light chain kinase, smooth muscle isoform X1

      UniProtKB/Swiss-Prot
      Q15746
      Conserved Domains (9) summary
      cd00096
      Location:640709
      Ig; Immunoglobulin domain
      cd05762
      Location:12381335
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:18211888
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:13311423
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:18081898
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:14611719
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam00069
      Location:14641719
      Pkinase; Protein kinase domain
      pfam16620
      Location:251412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:724809
      Ig; Immunoglobulin domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      123294136..123566156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005965.3: Suppressed sequence

      Description
      NM_005965.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_053029.2: Suppressed sequence

      Description
      NM_053029.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    3. NM_053030.2: Suppressed sequence

      Description
      NM_053030.2: This RefSeq was permanently suppressed because there was insufficient support for the transcript and the CDS was partial.
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