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    Gria2 glutamate ionotropic receptor AMPA type subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29627, updated on 16-Jul-2017
    Official Symbol
    Gria2provided by RGD
    Official Full Name
    glutamate ionotropic receptor AMPA type subunit 2provided by RGD
    Primary source
    RGD:61862
    See related
    Ensembl:ENSRNOG00000054204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GluA2; GluR2; gluR-B; GluR-K2
    Summary
    Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    2q33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (179584302..179704629, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (198991672..199113059, complement)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 198, member B Neighboring gene parkinson protein 7 pseudogene Neighboring gene microRNA 2985 Neighboring gene glycine receptor, beta Neighboring gene platelet derived growth factor C

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    AMPA glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    AMPA glutamate receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    PDZ domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SNARE binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    amyloid-beta binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to calcium channel regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoskeletal protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    extracellular-glutamate-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular-glutamate-gated ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ionotropic glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ionotropic glutamate receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    ionotropic glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    ionotropic glutamate receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    kainate selective glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    ionotropic glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    ionotropic glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    ionotropic glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein tetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of molecular function IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of receptor recycling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to fungicide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lithium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    AMPA glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    AMPA glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with amyloid-beta complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    asymmetric synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic shaft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ionotropic glutamate receptor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density of dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    glutamate receptor 2
    Names
    AMPA-selective glutamate receptor 2
    glutamate receptor B
    glutamate receptor, ionotropic, AMPA 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083811.1NP_001077280.1  glutamate receptor 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001077280.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region compared to transcript variant 1, and encodes an isoform (2, also known as the flop isoform) that is the same length as isoform 1, but with few amino acid differences. RNA editing changes Gln607Arg (CAG->CGG) and Arg764Gly (AGA->GGA).
      Source sequence(s)
      AABR07072744, AF164344, CO400088, M38061, M85035
      UniProtKB/Swiss-Prot
      P19491
      Related
      ENSRNOP00000069094.1, ENSRNOT00000077941.1
      Conserved Domains (4) summary
      cd06389
      Location:28397
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
      cd13715
      Location:413794
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:545824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:56379
      ANF_receptor; Receptor family ligand binding region
    2. NM_017261.2NP_058957.1  glutamate receptor 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_058957.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1 (also known as the flip isoform). RNA editing changes Gln607Arg (CAG->CGG) and Arg764Gly (AGA->GGA).
      Source sequence(s)
      AABR07072744, AF164344, CO400088, M38061
      UniProtKB/Swiss-Prot
      P19491
      Related
      ENSRNOP00000072906.1, ENSRNOT00000083361.1
      Conserved Domains (4) summary
      cd06389
      Location:28397
      PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
      cd13715
      Location:413794
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:545824
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:56379
      ANF_receptor; Receptor family ligand binding region

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      179584302..179704629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      159991989..160110044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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