Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    hh hedgehog [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42737, updated on 6-Sep-2016
    Official Symbol
    hhprovided by FlyBase
    Official Full Name
    hedgehogprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004644
    Locus tag
    Dmel_CG4637
    Gene type
    protein coding
    RNA name
    hedgehog
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0134654.19; anon-WO0182946.19; bar; bar-3; bar3; CG4637; Dmel\CG4637; hg; Hh; HH; l(3)hh; l(3)neo56; l(3)neo57; Mir; Mrt
    See hh in Map Viewer
    Location:
    94E1-94E1; 3-81.2 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.07 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23128169..23141906, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18953891..18967628, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Centaurin beta 1A Neighboring gene CG31365 gene product from transcript CG31365-RA Neighboring gene CG31457 gene product from transcript CG31457-RB Neighboring gene unkempt Neighboring gene Vacuolar H[+] ATPase AC39 subunit 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endopeptidase activity NAS
    Non-traceable Author Statement
    more info
     
    morphogen activity TAS
    Traceable Author Statement
    more info
    PubMed 
    patched binding NAS
    Non-traceable Author Statement
    more info
     
    patched binding TAS
    Traceable Author Statement
    more info
    PubMed 
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Bolwig's organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    R8 cell fate specification NAS
    Non-traceable Author Statement
    more info
    PubMed 
    analia development TAS
    Traceable Author Statement
    more info
    PubMed 
    anterior commissure morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterior head segmentation TAS
    Traceable Author Statement
    more info
    PubMed 
    anterior/posterior axis specification, embryo NAS
    Non-traceable Author Statement
    more info
    PubMed 
    anterior/posterior lineage restriction, imaginal disc TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
     
    compartment pattern specification TAS
    Traceable Author Statement
    more info
    PubMed 
    compound eye morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    compound eye photoreceptor cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    developmental pigmentation TAS
    Traceable Author Statement
    more info
    PubMed 
    ectoderm development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    embryonic pattern specification IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    epidermis development TAS
    Traceable Author Statement
    more info
    PubMed 
    epithelial cell migration, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    foregut morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    genital disc anterior/posterior pattern formation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    genital disc development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    genital disc development TAS
    Traceable Author Statement
    more info
    PubMed 
    germ cell attraction TAS
    Traceable Author Statement
    more info
    PubMed 
    germ cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ-line stem cell division TAS
    Traceable Author Statement
    more info
    PubMed 
    glial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gonadal mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    heart development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    heart development TAS
    Traceable Author Statement
    more info
    PubMed 
    heart formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hindgut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hindgut morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    imaginal disc growth TAS
    Traceable Author Statement
    more info
    PubMed 
    imaginal disc pattern formation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    imaginal disc-derived wing vein specification TAS
    Traceable Author Statement
    more info
    PubMed 
    intein-mediated protein splicing IEA
    Inferred from Electronic Annotation
    more info
     
    labial disc development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leg disc morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    mesoderm development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    morphogenesis of larval imaginal disc epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mucosal immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    open tracheal system development TAS
    Traceable Author Statement
    more info
    PubMed 
    ovarian follicle cell development TAS
    Traceable Author Statement
    more info
    PubMed 
    ovarian follicle cell stalk formation TAS
    Traceable Author Statement
    more info
    PubMed 
    pole cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hh target transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of smoothened signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of transcription factor import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    posterior head segmentation TAS
    Traceable Author Statement
    more info
    PubMed 
    progression of morphogenetic furrow involved in compound eye morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    progression of morphogenetic furrow involved in compound eye morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    progression of morphogenetic furrow involved in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    progression of morphogenetic furrow involved in compound eye morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    protein autoprocessing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autoprocessing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autoprocessing NAS
    Non-traceable Author Statement
    more info
     
    protein autoprocessing TAS
    Traceable Author Statement
    more info
     
    protein splicing TAS
    Traceable Author Statement
    more info
     
    regulation of cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of epithelial cell migration, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of organ growth TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    segment polarity determination IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    segment polarity determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    segment polarity determination NAS
    Non-traceable Author Statement
    more info
    PubMed 
    segment polarity determination TAS
    Traceable Author Statement
    more info
    PubMed 
    smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    smoothened signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    smoothened signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    somatic stem cell division TAS
    Traceable Author Statement
    more info
    PubMed 
    spiracle morphogenesis, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    trunk segmentation TAS
    Traceable Author Statement
    more info
    PubMed 
    ventral midline development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    wing disc anterior/posterior pattern formation TAS
    Traceable Author Statement
    more info
    PubMed 
    wing disc proximal/distal pattern formation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm NAS
    Non-traceable Author Statement
    more info
     
    cytoplasmic, membrane-bounded vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region NAS
    Non-traceable Author Statement
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    CG4637 gene product from transcript CG4637-RB
    Names
    CG4637-PB
    bar-on-3
    hedgehog
    hedghog
    hh-PB
    mirabile
    moonrat
    NP_001034065.1

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23128169..23141906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038976.1NP_001034065.1  hedgehog [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034065.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02936
      Related
      FBpp0099945, FBtr0100506
      Conserved Domains (3) summary
      cd00081
      Location:258400
      Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
      pfam01079
      Location:254465
      Hint; Hint module
      pfam01085
      Location:99243
      HH_signal; Hedgehog amino-terminal signalling domain
    Support Center