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    Fgfr3 fibroblast growth factor receptor 3 [ Mus musculus (house mouse) ]

    Gene ID: 14184, updated on 16-May-2017
    Official Symbol
    Fgfr3provided by MGI
    Official Full Name
    fibroblast growth factor receptor 3provided by MGI
    Primary source
    MGI:MGI:95524
    See related
    Ensembl:ENSMUSG00000054252 Vega:OTTMUSG00000021524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FR3; Mfr3; sam3; CD333; Flg-2; HBGFR; Fgfr-3
    Summary
    This gene encodes a member of the fibroblast growth factor receptor family. Members of this family are highly conserved proteins that differ from one another in their ligand affinities and tissue distribution. A representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene may be associated with craniosynostosis and multiple types of skeletal dysplasia. A pseudogene of this gene is located on chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]
    Orthologs
    Location:
    5 B2; 5 17.83 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (33721724..33737068)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (34064373..34079713)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 129 Neighboring gene transforming, acidic coiled-coil containing protein 3 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene predicted gene, 30708

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibroblast growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alveolar secondary septum development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    axonogenesis involved in innervation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone trabecula morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    central nervous system myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cochlea development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibroblast growth factor receptor apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear receptor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inner ear receptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lens fiber cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lens morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of astrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mitotic nuclear division IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oligodendrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation in bone marrow IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phospholipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    post-anal tail morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of collagen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to axon injury IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal system development IEA
    Inferred from Electronic Annotation
    more info
     
    somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    substantia nigra development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    fibroblast growth factor receptor 3
    Names
    heparin-binding growth factor receptor
    NP_001156687.1
    NP_001156688.1
    NP_001156689.1
    NP_001192199.1
    NP_032036.2
    XP_006503776.1
    XP_006503777.1
    XP_006503778.1
    XP_006503779.1
    XP_006503780.1
    XP_006503781.1
    XP_006503782.1
    XP_006503783.1
    XP_006503784.1
    XP_006503785.1
    XP_006503786.1
    XP_006503787.1
    XP_006503788.1
    XP_006503789.1
    XP_006503790.1
    XP_006503791.1
    XP_006503792.1
    XP_006503793.1
    XP_006503794.1
    XP_006503795.1
    XP_017176151.1
    XP_017176152.1
    XP_017176153.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163215.2NP_001156687.1  fibroblast growth factor receptor 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001156687.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1, also known as IIIc), which includes the IIIc-type C-terminal half of the IgIII domain.
      Source sequence(s)
      AC162898
      Consensus CDS
      CCDS51465.1
      UniProtKB/TrEMBL
      Q7TSI8
      Related
      ENSMUSP00000130856.2, ENSMUST00000169212.8
      Conserved Domains (7) summary
      cd05857
      Location:155239
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:262351
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:453786
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:51110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:52108
      IG; Immunoglobulin
      smart00410
      Location:254350
      IG_like; Immunoglobulin like
      pfam07714
      Location:466742
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_001163216.2NP_001156688.1  fibroblast growth factor receptor 3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001156688.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC162898, AF024638
      Consensus CDS
      CCDS51466.1
      UniProtKB/TrEMBL
      Q61563
      Related
      ENSMUSP00000143945.1, ENSMUST00000202138.3
      Conserved Domains (7) summary
      cd05857
      Location:137221
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:244333
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:435768
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:51110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:52108
      IG; Immunoglobulin
      smart00410
      Location:236332
      IG_like; Immunoglobulin like
      pfam07714
      Location:448724
      Pkinase_Tyr; Protein tyrosine kinase
    3. NM_001163217.2NP_001156689.1  fibroblast growth factor receptor 3 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001156689.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks a coding exon and includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3, also known as IIIb) is longer than isoform 1 and includes the IIIb-type C-terminal half of the IgIII domain. The combination of alternative exons and splice sites in the coding region is inferred based on human NM_001163213.1.
      Source sequence(s)
      AC162898
      UniProtKB/TrEMBL
      E9QNJ9
      Related
      ENSMUSP00000131845.2, ENSMUST00000171509.8
      Conserved Domains (7) summary
      cd04974
      Location:262350
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:155239
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:455788
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:51110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:52108
      IG; Immunoglobulin
      smart00410
      Location:254349
      IG_like; Immunoglobulin like
      pfam07714
      Location:468744
      Pkinase_Tyr; Protein tyrosine kinase
    4. NM_001205270.1NP_001192199.1  fibroblast growth factor receptor 3 isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
      Source sequence(s)
      AC162898
      Consensus CDS
      CCDS57335.1
      UniProtKB/TrEMBL
      F6TK14
      Related
      ENSMUSP00000133064.3, OTTMUSP00000062900, ENSMUST00000164207.9, OTTMUST00000112075
      Conserved Domains (7) summary
      cd05857
      Location:155239
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:262351
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:454787
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:51110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:52108
      IG; Immunoglobulin
      smart00410
      Location:254350
      IG_like; Immunoglobulin like
      pfam07714
      Location:467743
      Pkinase_Tyr; Protein tyrosine kinase
    5. NM_008010.5NP_032036.2  fibroblast growth factor receptor 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032036.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1, also known as IIIc, which includes the IIIc-type C-terminal half of the IgIII domain. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC162898, BC053056, CD349897
      Consensus CDS
      CCDS51465.1
      UniProtKB/TrEMBL
      Q7TSI8
      Related
      ENSMUSP00000070998.7, OTTMUSP00000023967, ENSMUST00000067150.13, OTTMUST00000051048
      Conserved Domains (7) summary
      cd05857
      Location:155239
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:262351
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:453786
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:51110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:52108
      IG; Immunoglobulin
      smart00410
      Location:254350
      IG_like; Immunoglobulin like
      pfam07714
      Location:466742
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      33721724..33737068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503725.1XP_006503788.1  fibroblast growth factor receptor 3 isoform X14

      See identical proteins and their annotated locations for XP_006503788.1

      Conserved Domains (7) summary
      cd04974
      Location:267355
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:155244
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:462795
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:51110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:52108
      IG; Immunoglobulin
      smart00410
      Location:259354
      IG_like; Immunoglobulin like
      pfam07714
      Location:475751
      Pkinase_Tyr; Protein tyrosine kinase
    2. XM_006503727.1XP_006503790.1  fibroblast growth factor receptor 3 isoform X15

      Conserved Domains (7) summary
      cd04974
      Location:262350
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:155239
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:457790
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:51110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:52108
      IG; Immunoglobulin
      smart00410
      Location:254349
      IG_like; Immunoglobulin like
      pfam07714
      Location:470746
      Pkinase_Tyr; Protein tyrosine kinase
    3. XM_006503728.1XP_006503791.1  fibroblast growth factor receptor 3 isoform X16

      See identical proteins and their annotated locations for XP_006503791.1

      UniProtKB/TrEMBL
      E9QNJ9
      Related
      ENSMUSP00000110053.2, ENSMUST00000114411.8
      Conserved Domains (7) summary
      cd04974
      Location:262350
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:155239
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:455788
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:51110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:52108
      IG; Immunoglobulin
      smart00410
      Location:254349
      IG_like; Immunoglobulin like
      pfam07714
      Location:468744
      Pkinase_Tyr; Protein tyrosine kinase
    4. XM_006503726.2XP_006503789.1  fibroblast growth factor receptor 3 isoform X14

      See identical proteins and their annotated locations for XP_006503789.1

      Conserved Domains (7) summary
      cd04974
      Location:267355
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:155244
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:462795
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:51110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:52108
      IG; Immunoglobulin
      smart00410
      Location:259354
      IG_like; Immunoglobulin like
      pfam07714
      Location:475751
      Pkinase_Tyr; Protein tyrosine kinase
    5. XM_006503730.2XP_006503793.1  fibroblast growth factor receptor 3 isoform X18

      See identical proteins and their annotated locations for XP_006503793.1

      Conserved Domains (7) summary
      cd04974
      Location:249337
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:137226
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:444777
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:51110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:52108
      IG; Immunoglobulin
      smart00410
      Location:241336
      IG_like; Immunoglobulin like
      pfam07714
      Location:457733
      Pkinase_Tyr; Protein tyrosine kinase
    6. XM_006503729.2XP_006503792.1  fibroblast growth factor receptor 3 isoform X18

      See identical proteins and their annotated locations for XP_006503792.1

      Conserved Domains (7) summary
      cd04974
      Location:249337
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:137226
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:444777
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:51110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:52108
      IG; Immunoglobulin
      smart00410
      Location:241336
      IG_like; Immunoglobulin like
      pfam07714
      Location:457733
      Pkinase_Tyr; Protein tyrosine kinase
    7. XM_017320663.1XP_017176152.1  fibroblast growth factor receptor 3 isoform X17

      UniProtKB/TrEMBL
      F6TK14
      Conserved Domains (7) summary
      cd05857
      Location:155239
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:262351
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:454787
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:51110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:52108
      IG; Immunoglobulin
      smart00410
      Location:254350
      IG_like; Immunoglobulin like
      pfam07714
      Location:467743
      Pkinase_Tyr; Protein tyrosine kinase
    8. XM_006503731.3XP_006503794.1  fibroblast growth factor receptor 3 isoform X19

      See identical proteins and their annotated locations for XP_006503794.1

      UniProtKB/TrEMBL
      Q61563
      Related
      ENSMUSP00000085122.4, OTTMUSP00000023968, ENSMUST00000087820.7, OTTMUST00000051049
      Conserved Domains (7) summary
      cd05857
      Location:137221
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:244333
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:435768
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:51110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:52108
      IG; Immunoglobulin
      smart00410
      Location:236332
      IG_like; Immunoglobulin like
      pfam07714
      Location:448724
      Pkinase_Tyr; Protein tyrosine kinase
    9. XM_006503713.3XP_006503776.1  fibroblast growth factor receptor 3 isoform X1

      Conserved Domains (7) summary
      cd04974
      Location:295383
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:183272
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:490823
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:79138
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:80136
      IG; Immunoglobulin
      smart00410
      Location:287382
      IG_like; Immunoglobulin like
      pfam07714
      Location:503779
      Pkinase_Tyr; Protein tyrosine kinase
    10. XM_006503714.3XP_006503777.1  fibroblast growth factor receptor 3 isoform X2

      Conserved Domains (7) summary
      cd04974
      Location:295383
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:183272
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:489822
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:79138
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:80136
      IG; Immunoglobulin
      smart00410
      Location:287382
      IG_like; Immunoglobulin like
      pfam07714
      Location:502778
      Pkinase_Tyr; Protein tyrosine kinase
    11. XM_006503723.3XP_006503786.1  fibroblast growth factor receptor 3 isoform X12

      Conserved Domains (6) summary
      cd04974
      Location:277365
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:165254
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:472805
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:79138
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:269364
      IG_like; Immunoglobulin like
      pfam07714
      Location:485761
      Pkinase_Tyr; Protein tyrosine kinase
    12. XM_006503716.3XP_006503779.1  fibroblast growth factor receptor 3 isoform X4

      Conserved Domains (7) summary
      cd04974
      Location:295383
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:183272
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:488821
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:79138
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:80136
      IG; Immunoglobulin
      smart00410
      Location:287382
      IG_like; Immunoglobulin like
      pfam07714
      Location:501777
      Pkinase_Tyr; Protein tyrosine kinase
    13. XM_006503715.3XP_006503778.1  fibroblast growth factor receptor 3 isoform X3

      Conserved Domains (7) summary
      cd05857
      Location:183272
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:295384
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:488821
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:79138
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:80136
      IG; Immunoglobulin
      smart00410
      Location:287383
      IG_like; Immunoglobulin like
      pfam07714
      Location:501777
      Pkinase_Tyr; Protein tyrosine kinase
    14. XM_006503717.3XP_006503780.1  fibroblast growth factor receptor 3 isoform X5

      Conserved Domains (7) summary
      cd05857
      Location:183272
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:295384
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:487820
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:79138
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:80136
      IG; Immunoglobulin
      smart00410
      Location:287383
      IG_like; Immunoglobulin like
      pfam07714
      Location:500776
      Pkinase_Tyr; Protein tyrosine kinase
    15. XM_006503719.2XP_006503782.1  fibroblast growth factor receptor 3 isoform X7

      Conserved Domains (7) summary
      cd04974
      Location:290378
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:183267
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:485818
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:79138
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:80136
      IG; Immunoglobulin
      smart00410
      Location:282377
      IG_like; Immunoglobulin like
      pfam07714
      Location:498774
      Pkinase_Tyr; Protein tyrosine kinase
    16. XM_006503718.2XP_006503781.1  fibroblast growth factor receptor 3 isoform X6

      Conserved Domains (7) summary
      cd05857
      Location:183272
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:295384
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:486819
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:79138
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:80136
      IG; Immunoglobulin
      smart00410
      Location:287383
      IG_like; Immunoglobulin like
      pfam07714
      Location:499775
      Pkinase_Tyr; Protein tyrosine kinase
    17. XM_006503721.2XP_006503784.1  fibroblast growth factor receptor 3 isoform X9

      Conserved Domains (8) summary
      cd04974
      Location:290378
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:183267
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:483816
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:79138
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:80136
      IG; Immunoglobulin
      smart00410
      Location:282377
      IG_like; Immunoglobulin like
      pfam07679
      Location:193267
      I-set; Immunoglobulin I-set domain
      pfam07714
      Location:496772
      Pkinase_Tyr; Protein tyrosine kinase
    18. XM_006503720.3XP_006503783.1  fibroblast growth factor receptor 3 isoform X8

      Conserved Domains (7) summary
      cd05857
      Location:183267
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:290379
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:483816
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:79138
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:80136
      IG; Immunoglobulin
      smart00410
      Location:282378
      IG_like; Immunoglobulin like
      pfam07714
      Location:496772
      Pkinase_Tyr; Protein tyrosine kinase
    19. XM_017320662.1XP_017176151.1  fibroblast growth factor receptor 3 isoform X10

    20. XM_006503724.3XP_006503787.1  fibroblast growth factor receptor 3 isoform X13

      Conserved Domains (8) summary
      cd05857
      Location:165249
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:272361
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:465798
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:79138
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:80136
      IG; Immunoglobulin
      smart00410
      Location:264360
      IG_like; Immunoglobulin like
      pfam07679
      Location:175249
      I-set; Immunoglobulin I-set domain
      pfam07714
      Location:478754
      Pkinase_Tyr; Protein tyrosine kinase
    21. XM_006503722.3XP_006503785.1  fibroblast growth factor receptor 3 isoform X11

      Conserved Domains (7) summary
      cd05857
      Location:183267
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:290379
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:481814
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:79138
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:80136
      IG; Immunoglobulin
      smart00410
      Location:282378
      IG_like; Immunoglobulin like
      pfam07714
      Location:494770
      Pkinase_Tyr; Protein tyrosine kinase
    22. XM_006503732.3XP_006503795.1  fibroblast growth factor receptor 3 isoform X20

      Conserved Domains (6) summary
      cd04974
      Location:110198
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:387
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:305638
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00410
      Location:102197
      IG_like; Immunoglobulin like
      pfam07679
      Location:1387
      I-set; Immunoglobulin I-set domain
      pfam07714
      Location:318594
      Pkinase_Tyr; Protein tyrosine kinase
    23. XM_017320664.1XP_017176153.1  fibroblast growth factor receptor 3 isoform X21

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