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    SIR3 chromatin-silencing protein SIR3 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 851163, updated on 5-Mar-2017
    Gene symbol
    SIR3
    Gene description
    chromatin-silencing protein SIR3
    Primary source
    SGD:S000004434
    Locus tag
    YLR442C
    Gene type
    protein coding
    RNA name
    chromatin-silencing protein SIR3
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CMT1; MAR2; STE8
    See SIR3 in Map Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1019315..1022251, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Sec39p Neighboring gene ribosomal 40S subunit protein S1A Neighboring gene Ecm7p Neighboring gene Gmc2p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleosomal histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome, telomeric region IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear telomeric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    chromatin-silencing protein SIR3
    NP_013547.3
    • Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1019315..1022251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182330.3NP_013547.3  TPA: chromatin-silencing protein SIR3 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_013547.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P06701
      Conserved Domains (2) summary
      COG1474
      Location:528962
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      cd04720
      Location:5189
      BAH_Orc1p_Yeast; BAH, or Bromo Adjacent Homology domain, as present in Orc1p, which again is part of the Saccharomyces cerevisiae Sir1-origin recognition complex, and as present in Sir3p. The Orc1p BAH doman functions in epigenetic silencing. BAH domains are found in a ...
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