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    Thrb thyroid hormone receptor beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24831, updated on 7-May-2017
    Official Symbol
    Thrbprovided by RGD
    Official Full Name
    thyroid hormone receptor betaprovided by RGD
    Primary source
    RGD:3858
    See related
    Ensembl:ENSRNOG00000006649
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ERBA2; Nr1a2; T3rec; TRbeta; RATT3REC; C-erba-beta
    Summary
    nuclear hormone receptor for triiodothyronine (T3); mediates the biological activities of thyroid hormone [RGD, Feb 2006]
    Orthologs
    Location:
    15p16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (8890578..9239815, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 15 NC_005114.3 (12951550..13299586, complement)

    Chromosome 15 - NC_005114.4Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 1, group D, member 2 Neighboring gene similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Neighboring gene eukaryotic translation initiation factor 1 pseudogene Neighboring gene uncharacterized LOC102554203 Neighboring gene uncharacterized LOC108352884

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    thyroid hormone binding IEA
    Inferred from Electronic Annotation
    more info
     
    thyroid hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    thyroid hormone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    thyroid hormone receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thyroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    thyroid hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Type I pneumocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Type I pneumocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic organ development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    female courtship behavior IEA
    Inferred from Electronic Annotation
    more info
     
    female courtship behavior ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of female receptivity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of female receptivity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chondrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ossification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart contraction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    thyroid hormone receptor beta
    Names
    TRbeta2Delta
    c-erbA-2
    nuclear receptor subfamily 1 group A member 2
    thyroid hormone receptor beta 3
    thyroid hormone receptor beta2delta
    thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270854.1NP_001257783.1  thyroid hormone receptor beta isoform 2

      See identical proteins and their annotated locations for NP_001257783.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AABR07017058, AABR07017059, AABR07017060
      UniProtKB/TrEMBL
      F1LQ07
      Related
      ENSRNOP00000008989.2, ENSRNOT00000008989.5
      Conserved Domains (2) summary
      cd06935
      Location:216458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    2. NM_012672.3NP_036804.2  thyroid hormone receptor beta isoform 1

      See identical proteins and their annotated locations for NP_036804.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AABR07017058, AABR07017059, AABR07017060
      UniProtKB/TrEMBL
      Q3HW36
      Conserved Domains (2) summary
      cd06935
      Location:252494
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106228
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005114.4 Reference Rnor_6.0 Primary Assembly

      Range
      8890578..9239815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599581.1XP_017455070.1  thyroid hormone receptor beta isoform X3

      UniProtKB/TrEMBL
      Q3HW36
      Conserved Domains (2) summary
      cd06935
      Location:252494
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106228
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
    2. XM_017599580.1XP_017455069.1  thyroid hormone receptor beta isoform X1

      Related
      ENSRNOP00000073083.1, ENSRNOT00000085322.1
    3. XM_006251709.3XP_006251771.1  thyroid hormone receptor beta isoform X2

      See identical proteins and their annotated locations for XP_006251771.1

      Conserved Domains (2) summary
      cd06935
      Location:269511
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:159245
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    Alternate Rn_Celera

    Genomic

    1. AC_000083.1 Alternate Rn_Celera

      Range
      7735185..8077355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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