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    Jup junction plakoglobin [ Mus musculus (house mouse) ]

    Gene ID: 16480, updated on 23-May-2018
    Official Symbol
    Jupprovided by MGI
    Official Full Name
    junction plakoglobinprovided by MGI
    Primary source
    MGI:MGI:96650
    See related
    Ensembl:ENSMUSG00000001552 Vega:OTTMUSG00000006276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PG; Ctnng; D930025P04Rik
    Expression
    Broad expression in lung adult (RPKM 160.5), stomach adult (RPKM 151.6) and 23 other tissues See more
    Orthologs
    See Jup in Genome Data Viewer
    Location:
    11 D; 11 63.47 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (100368856..100397805, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (100231933..100259053, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene huntingtin-associated protein 1 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c, isoform 1 pseudogene Neighboring gene predicted gene 12348 Neighboring gene prolyl 3-hydroxylase family member 4 (non-enzymatic)

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    alpha-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    alpha-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    alpha-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    structural molecule activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    bundle of His cell-Purkinje myocyte adhesion involved in cell communication ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to indole-3-methanol ISO
    Inferred from Sequence Orthology
    more info
     
    desmosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    desmosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    detection of mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    apicolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    catenin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catenin complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    desmosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    desmosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    desmosome ISO
    Inferred from Sequence Orthology
    more info
     
    fascia adherens ISO
    Inferred from Sequence Orthology
    more info
     
    gamma-catenin-TCF7L2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    intermediate filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    junction plakoglobin
    Names
    desmoplakin III
    desmoplakin-3
    gamma-catenin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010593.2NP_034723.1  junction plakoglobin

      See identical proteins and their annotated locations for NP_034723.1

      Status: VALIDATED

      Source sequence(s)
      AK145895, AL590968, CD555608
      Consensus CDS
      CCDS25420.1
      UniProtKB/Swiss-Prot
      Q02257
      Related
      ENSMUSP00000001592.8, OTTMUSP00000006595, ENSMUST00000001592.14, OTTMUST00000014199
      Conserved Domains (2) summary
      cd00020
      Location:476613
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:393418
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      100368856..100397805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532315.3XP_006532378.1  junction plakoglobin isoform X1

      See identical proteins and their annotated locations for XP_006532378.1

      UniProtKB/Swiss-Prot
      Q02257
      Related
      ENSMUSP00000103026.1, OTTMUSP00000006596, ENSMUST00000107403.1, OTTMUST00000014200
      Conserved Domains (2) summary
      cd00020
      Location:476613
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:393418
      ARM; armadillo repeat [structural motif]
    2. XM_006532316.1XP_006532379.1  junction plakoglobin isoform X1

      See identical proteins and their annotated locations for XP_006532379.1

      UniProtKB/Swiss-Prot
      Q02257
      Conserved Domains (2) summary
      cd00020
      Location:476613
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:393418
      ARM; armadillo repeat [structural motif]
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