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    FES FES proto-oncogene, tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 2242, updated on 11-May-2017
    Official Symbol
    FESprovided by HGNC
    Official Full Name
    FES proto-oncogene, tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:3657
    See related
    Ensembl:ENSG00000182511 MIM:190030; Vega:OTTHUMG00000044456
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FPS
    Summary
    This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]
    Orthologs
    Location:
    15q26.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (90884421..90895776)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91427665..91439006)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 363, pseudogene Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene mannosidase alpha class 2A member 2 Neighboring gene unc-45 myosin chaperone A Neighboring gene HD domain containing 3

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
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    NHGRI GWA Catalog
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    NHGRI GWA Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    NHGRI GWA Catalog
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      Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem
      Angiopoietin receptor Tie2-mediated signaling
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • CRMPs in Sema3A signaling, organism-specific biosystem (from REACTOME)
      CRMPs in Sema3A signaling, organism-specific biosystemCRMPs are a small family of plexinA-interacting cytosolic phosphoproteins identified as mediators of Sema3A signaling and neuronal differentiation. After Sema3A activation Plexin-A bound CRMP's under...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • IL-4 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-4 Signaling Pathway, organism-specific biosystemIL-4 is a glycoprotein which is composed of 129 amino acids and has a molecular weight of 20kDa. IL-4 and IL-13 are produced by CD4+ cells and exhibit significant functional overlap. Both these cytok...
    • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL4-mediated signaling events, organism-specific biosystem
      IL4-mediated signaling events
    • Interleukin-11 Signaling Pathway, organism-specific biosystem (from WikiPathways)
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    • Sema3A PAK dependent Axon repulsion, organism-specific biosystem (from REACTOME)
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    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
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    • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
      Signaling events mediated by VEGFR1 and VEGFR2
    • Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, organism-specific biosystem
      Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    immunoglobulin receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    centrosome cycle IEA
    Inferred from Electronic Annotation
    more info
     
    chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule bundle formation IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development TAS
    Traceable Author Statement
    more info
    PubMed 
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    tyrosine-protein kinase Fes/Fps
    Names
    Oncogene FES, feline sarcoma virus
    feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog
    feline sarcoma oncogene
    feline sarcoma/Fujinami avian sarcoma oncogene homolog
    p93c-fes
    proto-oncogene c-Fes
    proto-oncogene c-Fps
    proto-oncogene tyrosine-protein kinase Fes/Fps
    NP_001137255.1
    NP_001137256.1
    NP_001137257.1
    NP_001996.1
    XP_005254937.1
    XP_005254939.1
    XP_016877494.1
    XP_016877495.1
    XP_016877496.1
    XP_016877497.1
    XP_016877498.1
    XP_016877499.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029671.1 RefSeqGene

      Range
      5001..16319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001143783.1NP_001137255.1  tyrosine-protein kinase Fes/Fps isoform 2

      See identical proteins and their annotated locations for NP_001137255.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, and encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC124248, AY513656
      Consensus CDS
      CCDS45350.1
      UniProtKB/Swiss-Prot
      P07332
      Related
      ENSP00000377837.3, OTTHUMP00000195202, ENST00000394300.7, OTTHUMT00000314024
      Conserved Domains (4) summary
      cd10361
      Location:395479
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:506757
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:503756
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_001143784.1NP_001137256.1  tyrosine-protein kinase Fes/Fps isoform 3

      See identical proteins and their annotated locations for NP_001137256.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a protein (isoform 3) with a shorter C-terminus and an incomplete SH2 domain, compared to isoform 1.
      Source sequence(s)
      AC124248, AY513657
      Consensus CDS
      CCDS45349.1
      UniProtKB/Swiss-Prot
      P07332
      Related
      ENSP00000400868.2, OTTHUMP00000233984, ENST00000444422.2, OTTHUMT00000391051
      Conserved Domains (3) summary
      cd05084
      Location:494745
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:491744
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7239
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. NM_001143785.1NP_001137257.1  tyrosine-protein kinase Fes/Fps isoform 4

      See identical proteins and their annotated locations for NP_001137257.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks multiple in-frame exons in the coding region, compared to variant 1, and encodes a shorter protein (isoform 4) with an incomplete SH2 domain, compared to isoform 1.
      Source sequence(s)
      AC124248, AY513654, DB264752
      Consensus CDS
      CCDS45351.1
      UniProtKB/Swiss-Prot
      P07332
      Related
      ENSP00000414629.2, OTTHUMP00000233982, ENST00000414248.6, OTTHUMT00000391050
      Conserved Domains (3) summary
      cd05084
      Location:436687
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:433686
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    4. NM_002005.3NP_001996.1  tyrosine-protein kinase Fes/Fps isoform 1

      See identical proteins and their annotated locations for NP_001996.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC124248, DA782386, X52192
      Consensus CDS
      CCDS10365.1
      UniProtKB/Swiss-Prot
      P07332
      UniProtKB/TrEMBL
      A0A024RC92
      Related
      ENSP00000331504.3, OTTHUMP00000194752, ENST00000328850.7, OTTHUMT00000313497
      Conserved Domains (4) summary
      cd07685
      Location:7239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:564815
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:561814
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      90884421..90895776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022008.1XP_016877497.1  tyrosine-protein kinase Fes/Fps isoform X4

      UniProtKB/Swiss-Prot
      P07332
      Conserved Domains (3) summary
      cd05084
      Location:436687
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:433686
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_017022006.1XP_016877495.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/Swiss-Prot
      P07332
      Conserved Domains (4) summary
      cd10361
      Location:395479
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:506757
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:503756
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. XM_005254882.1XP_005254939.1  tyrosine-protein kinase Fes/Fps isoform X3

      See identical proteins and their annotated locations for XP_005254939.1

      UniProtKB/Swiss-Prot
      P07332
      Conserved Domains (3) summary
      cd05084
      Location:494745
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:491744
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7239
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    4. XM_017022010.1XP_016877499.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/Swiss-Prot
      P07332
      Conserved Domains (4) summary
      cd10361
      Location:395479
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:506757
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:503756
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    5. XM_005254880.1XP_005254937.1  tyrosine-protein kinase Fes/Fps isoform X2

      See identical proteins and their annotated locations for XP_005254937.1

      UniProtKB/Swiss-Prot
      P07332
      Conserved Domains (4) summary
      cd10361
      Location:395479
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:506757
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:503756
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    6. XM_017022005.1XP_016877494.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/Swiss-Prot
      P07332
      UniProtKB/TrEMBL
      A0A024RC92
      Conserved Domains (4) summary
      cd07685
      Location:7239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:564815
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:561814
      Pkinase_Tyr; Protein tyrosine kinase
    7. XM_017022007.1XP_016877496.1  tyrosine-protein kinase Fes/Fps isoform X3

      UniProtKB/Swiss-Prot
      P07332
      Conserved Domains (3) summary
      cd05084
      Location:494745
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:491744
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7239
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    8. XM_017022009.1XP_016877498.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/Swiss-Prot
      P07332
      UniProtKB/TrEMBL
      A0A024RC92
      Conserved Domains (4) summary
      cd07685
      Location:7239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:564815
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:561814
      Pkinase_Tyr; Protein tyrosine kinase

    RNA

    1. XR_001751144.1 RNA Sequence

      Related
      ENST00000464684.5, OTTHUMT00000314022
    2. XR_243206.2 RNA Sequence

    3. XR_001751142.1 RNA Sequence

    4. XR_001751143.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      91269239..91280594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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