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    HCVgp1 polyprotein [ Hepatitis C virus ]

    Gene ID: 951475, updated on 13-May-2017
    Gene symbol
    HCVgp1
    Gene description
    polyprotein
    Locus tag
    HCVgp1
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Hepatitis C virus (serotype: 1a, isolate: H77)
    Lineage
    Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae; Hepacivirus
    Sequence:
    NC_004102.1 (342..9377)

    NC_004102.1Genomic Context describing neighboring genes Neighboring gene protein F

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description
    Names
    polyprotein
    core protein
    E1 protein
    E2 protein
    p7 protein
    NS2 protein
    NS3 protease/helicase
    NS4A protein
    NS4B protein
    NS5A protein
    NS5B RNA-dependent RNA polymerase

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004102.1 Reference assembly

      Range
      342..9377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_671491.1 polyprotein [Hepatitis C virus]

      See identical proteins and their annotated locations for NP_671491.1

      Status: REVIEWED

      Conserved Domains (16) summary
      pfam01001
      Location:17281921
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b
      pfam01539
      Location:193382
      HCV_env; Hepatitis C virus envelope glycoprotein E1
      pfam01560
      Location:386729
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
      pfam02907
      Location:10561204
      Peptidase_S29; Hepatitis C virus NS3 protease
      pfam01543
      Location:2115
      HCV_capsid; Hepatitis C virus capsid protein
      pfam08301
      Location:20682168
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam01538
      Location:8111005
      HCV_NS2; Hepatitis C virus non-structural protein NS2
      smart00487
      Location:12281355
      DEXDc; DEAD-like helicases superfamily
      cd00046
      Location:12241351
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:13781455
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00998
      Location:24232934
      RdRP_3; Viral RNA dependent RNA polymerase
      pfam01006
      Location:16581711
      HCV_NS4a; Hepatitis C virus non-structural protein NS4a
      pfam01506
      Location:19741996
      HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
      pfam01542
      Location:116190
      HCV_core; Hepatitis C virus core protein
      pfam08300
      Location:20062067
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain
      pfam12941
      Location:21792420
      HCV_NS5a_C; HCV NS5a protein C-terminal region
    2. NP_751919.1 core protein

      Conserved Domains (2) summary
      pfam01543
      Location:2115
      HCV_capsid; Hepatitis C virus capsid protein
      pfam01542
      Location:116190
      HCV_core; Hepatitis C virus core protein
    3. NP_751920.1 E1 protein

      Conserved Domains (1) summary
      pfam01539
      Location:2191
      HCV_env; Hepatitis C virus envelope glycoprotein E1
    4. NP_751921.1 E2 protein

      Conserved Domains (1) summary
      pfam01560
      Location:3346
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
    5. NP_751922.1 p7 protein

      Conserved Domains (1) summary
      cl09930
      Location:2348
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    6. NP_751923.1 NS2 protein

      Conserved Domains (1) summary
      pfam01538
      Location:2196
      HCV_NS2; Hepatitis C virus non-structural protein NS2
    7. NP_803144.1 NS3 protease/helicase

      Conserved Domains (4) summary
      pfam02907
      Location:30178
      Peptidase_S29; Hepatitis C virus NS3 protease
      smart00487
      Location:202329
      DEXDc; DEAD-like helicases superfamily
      cd00046
      Location:198325
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:352429
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    8. NP_751925.1 NS4A protein

      Conserved Domains (1) summary
      pfam01006
      Location:154
      HCV_NS4a; Hepatitis C virus non-structural protein NS4a
    9. NP_751926.1 NS4B protein

      Conserved Domains (1) summary
      pfam01001
      Location:17210
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b
    10. NP_751927.1 NS5A protein

      Conserved Domains (4) summary
      pfam08301
      Location:96196
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam01506
      Location:224
      HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
      pfam08300
      Location:3495
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain
      pfam12941
      Location:207448
      HCV_NS5a_C; HCV NS5a protein C-terminal region
    11. NP_751928.1 NS5B RNA-dependent RNA polymerase

      Conserved Domains (1) summary
      pfam00998
      Location:3514
      RdRP_3; Viral RNA dependent RNA polymerase
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