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    CDC6 AAA family ATPase CDC6 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 853244, updated on 27-Mar-2017
    Gene symbol
    CDC6
    Gene description
    AAA family ATPase CDC6
    Primary source
    SGD:S000003730
    Locus tag
    YJL194W
    Gene type
    protein coding
    RNA name
    AAA family ATPase CDC6
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See CDC6 in Map Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (69338..70879)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene putative ubiquitin-specific protease UBP12 Neighboring gene fatty acid elongase ELO1 Neighboring gene hypothetical protein Neighboring gene Sop4p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell Cycle and Cell Division, organism-specific biosystem (from WikiPathways)
      Cell Cycle and Cell Division, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle - yeast, organism-specific biosystem (from KEGG)
      Cell cycle - yeast, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
    • Cell cycle - yeast, conserved biosystem (from KEGG)
      Cell cycle - yeast, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
    • DNA Replication, organism-specific biosystem (from WikiPathways)
      DNA Replication, organism-specific biosystemDNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original ...
    • Meiosis - yeast, organism-specific biosystem (from KEGG)
      Meiosis - yeast, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
    • Meiosis - yeast, conserved biosystem (from KEGG)
      Meiosis - yeast, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA replication origin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
     
    G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    pre-replicative complex assembly involved in nuclear cell cycle DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pre-replicative complex assembly involved in nuclear cell cycle DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of DNA-dependent DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of chromatin silencing at telomere IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    DNA replication preinitiation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear pre-replicative complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    AAA family ATPase CDC6
    NP_012341.1
    • Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress; degraded in response to plasma membrane stress

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      69338..70879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181627.1NP_012341.1  TPA: AAA family ATPase CDC6 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_012341.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P09119
      Conserved Domains (3) summary
      COG1474
      Location:77508
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam13401
      Location:103261
      AAA_22; AAA domain
      cl08520
      Location:413473
      Cdc6_C; Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding
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