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    TNRC6A trinucleotide repeat containing 6A [ Homo sapiens (human) ]

    Gene ID: 27327, updated on 5-Nov-2017
    Official Symbol
    TNRC6Aprovided by HGNC
    Official Full Name
    trinucleotide repeat containing 6Aprovided by HGNC
    Primary source
    HGNC:HGNC:11969
    See related
    Ensembl:ENSG00000090905 MIM:610739; Vega:OTTHUMG00000096999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GW1; GW182; TNRC6; CAGH26
    Summary
    This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    16p12.1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (24610260..24826227)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (24741028..24837548)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RB binding protein 6, ubiquitin ligase Neighboring gene acyl-CoA-binding domain-containing protein 7-like Neighboring gene long intergenic non-protein coding RNA 1567 Neighboring gene uncharacterized LOC107984825 Neighboring gene solute carrier family 5 member 11

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef inhibits the sorting of GW182 into exosomes, leading to affect assembly and turnover of the miRNA-induced silencing complex (miRISC) PubMed

    Go to the HIV-1, Human Interaction Database

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      Gene Silencing by RNA, organism-specific biosystemIn this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated.
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
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    • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
      MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
    • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
      MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
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      Oxidative Stress Induced Senescence, organism-specific biosystemOxidative stress, caused by increased concentration of reactive oxygen species (ROS) in the cell, can happen as a consequence of mitochondrial dysfunction induced by the oncogenic RAS (Moiseeva et al...
    • PI3K/AKT activation, organism-specific biosystem (from REACTOME)
      PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
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    • Post-transcriptional silencing by small RNAs, organism-specific biosystem (from REACTOME)
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    • Pre-NOTCH Expression and Processing, organism-specific biosystem (from REACTOME)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ22043, KIAA1460, MGC75384, DKFZp666E117

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway, calcium modulating pathway TAS
    Traceable Author Statement
    more info
     
    gene silencing by miRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    miRNA mediated inhibition of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    posttranscriptional gene silencing by RNA TAS
    Traceable Author Statement
    more info
     
    regulation of gene silencing by miRNA TAS
    Traceable Author Statement
    more info
     
    regulation of megakaryocyte differentiation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    micro-ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    trinucleotide repeat-containing gene 6A protein
    Names
    CAG repeat protein 26
    CTD-2540M10.1
    EDIE
    EMSY interactor protein
    GW182 autoantigen
    glycine-tryptophan protein of 182 kDa

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330520.2NP_001317449.1  trinucleotide repeat-containing gene 6A protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC002565, AC008731, BU743266
      Consensus CDS
      CCDS81959.1
      UniProtKB/Swiss-Prot
      Q8NDV7
      Conserved Domains (4) summary
      cd12711
      Location:17311813
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10691200
      Ago_hook; Argonaute hook
      pfam12938
      Location:12801411
      M_domain; M domain of GW182
      pfam16608
      Location:14551730
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    2. NM_001351850.1NP_001338779.1  trinucleotide repeat-containing gene 6A protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC008731, AC010321, BU743266
      Conserved Domains (4) summary
      cd12711
      Location:17401822
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10841209
      Ago_hook; Argonaute hook
      pfam12938
      Location:12651373
      M_domain; M domain of GW182
      pfam16608
      Location:14641727
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    3. NM_014494.3NP_055309.2  trinucleotide repeat-containing gene 6A protein isoform 1

      See identical proteins and their annotated locations for NP_055309.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC002565, AC008731, AJ492221, BE158958, BU743266
      Consensus CDS
      CCDS10624.2
      UniProtKB/Swiss-Prot
      Q8NDV7
      Related
      ENSP00000379144.3, OTTHUMP00000122485, ENST00000395799.7
      Conserved Domains (4) summary
      cd12711
      Location:17801862
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10691200
      Ago_hook; Argonaute hook
      pfam12938
      Location:12951413
      M_domain; M domain of GW182
      pfam16608
      Location:15041779
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

      Range
      24610260..24826227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023147.1XP_016878636.1  trinucleotide repeat-containing gene 6A protein isoform X5

      Conserved Domains (4) summary
      cd12711
      Location:17401822
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10841209
      Ago_hook; Argonaute hook
      pfam12938
      Location:12651373
      M_domain; M domain of GW182
      pfam16608
      Location:14641727
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    2. XM_017023145.1XP_016878634.1  trinucleotide repeat-containing gene 6A protein isoform X3

    3. XM_017023143.1XP_016878632.1  trinucleotide repeat-containing gene 6A protein isoform X1

    4. XM_017023144.1XP_016878633.1  trinucleotide repeat-containing gene 6A protein isoform X2

    5. XM_017023152.1XP_016878641.1  trinucleotide repeat-containing gene 6A protein isoform X11

    6. XM_017023150.1XP_016878639.1  trinucleotide repeat-containing gene 6A protein isoform X9

    7. XM_017023149.1XP_016878638.1  trinucleotide repeat-containing gene 6A protein isoform X8

    8. XM_017023148.1XP_016878637.1  trinucleotide repeat-containing gene 6A protein isoform X7

    9. XM_017023151.1XP_016878640.1  trinucleotide repeat-containing gene 6A protein isoform X10

    10. XM_017023146.1XP_016878635.1  trinucleotide repeat-containing gene 6A protein isoform X4

    11. XM_017023153.1XP_016878642.1  trinucleotide repeat-containing gene 6A protein isoform X12

      UniProtKB/Swiss-Prot
      Q8NDV7
      Conserved Domains (4) summary
      cd12711
      Location:15271609
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:816947
      Ago_hook; Argonaute hook
      pfam12938
      Location:10421160
      M_domain; M domain of GW182
      pfam16608
      Location:12511526
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    12. XM_017023154.1XP_016878643.1  trinucleotide repeat-containing gene 6A protein isoform X13

    13. XM_005255254.3XP_005255311.1  trinucleotide repeat-containing gene 6A protein isoform X6

      Related
      ENSP00000326900.7, OTTHUMP00000195164, ENST00000315183.11, OTTHUMT00000313982
      Conserved Domains (4) summary
      cd12711
      Location:17311813
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10691200
      Ago_hook; Argonaute hook
      pfam12938
      Location:12801411
      M_domain; M domain of GW182
      pfam16608
      Location:14551730
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    14. XM_005255257.4XP_005255314.1  trinucleotide repeat-containing gene 6A protein isoform X12

      See identical proteins and their annotated locations for XP_005255314.1

      UniProtKB/Swiss-Prot
      Q8NDV7
      Conserved Domains (4) summary
      cd12711
      Location:15271609
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:816947
      Ago_hook; Argonaute hook
      pfam12938
      Location:10421160
      M_domain; M domain of GW182
      pfam16608
      Location:12511526
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      25755032..25851538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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