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    pncA pyrazinamidase/nicotinamidase PncA [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888260, updated on 10-Feb-2017
    Gene symbol
    pncA
    Gene description
    pyrazinamidase/nicotinamidase PncA
    Locus tag
    Rv2043c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Sequence:
    NC_000962.3 (2288681..2289241, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene sugar ABC transporter permease Neighboring gene sugar ABC transporter substrate-binding lipoprotein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene carboxylesterase LipT

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Names
    pyrazinamidase/nicotinamidase PncA
    NP_216559.1
    • involved in susceptibility or resistance to antituberculous drug pyrazinamide.

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      2288681..2289241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_216559.1 pyrazinamidase/nicotinamidase PncA [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_216559.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      I6XD65
      Conserved Domains (1) summary
      cd01011
      Location:1183
      nicotinamidase; Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is ...
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