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    FN1 fibronectin 1 [ Homo sapiens (human) ]

    Gene ID: 2335, updated on 27-Mar-2017
    Official Symbol
    FN1provided by HGNC
    Official Full Name
    fibronectin 1provided by HGNC
    Primary source
    HGNC:HGNC:3778
    See related
    Ensembl:ENSG00000115414 MIM:135600; Vega:OTTHUMG00000133054
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2
    Summary
    This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
    Orthologs
    Location:
    2q35
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (215360440..215436167, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (216225177..216300890, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928103 Neighboring gene ATP binding cassette subfamily A member 12 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene uncharacterized LOC105373868 Neighboring gene uncharacterized LOC102724849

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Glomerulopathy with fibronectin deposits 2
    MedGen: C1866075 OMIM: 601894 GeneReviews: Not available
    Compare labs
    Plasma fibronectin deficiency
    MedGen: C2675436 OMIM: 614101 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
    NHGRI GWA Catalog
    Discovery and refinement of loci associated with lipid levels.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 induces phosphorylation of fibronectin and enhances a physical association between fibronectin and Robo4 in human lymphatic endothelial cells PubMed
    env Fibronectin, which is present in submandibular saliva, binds to HIV-1 gp120/160 and enhances the interaction of C1q with gp120/160 PubMed
    env HIV-1 gp120 binds to fibronectin (FN) present on the surface of platelets; the specificity of this binding is confirmed by the inhibition obtained by pretreating platelets with anti-FN antibodies PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 and gp120 specifically recognize the C-terminal heparin-binding domain of fibronectin (Fn) and this binding inhibits the interaction of gp160/gp120 with soluble CD4 PubMed
    Envelope transmembrane glycoprotein gp41 env Fibronectin (FN) binds to HIV-1 glycoproteins, including gp41 and gp120; preincubation with antibodies against FN abolishes this binding PubMed
    Nef nef Exogenous HIV-1 Nef upregulates fibronectin (FN) expression in MT4 and H9 T-cell lines PubMed
    Tat tat HIV-1 Tat competes with fibronectin for binding to integrins PubMed
    tat Fibronectin modulates the effects of HIV-1 Tat on endothelial cells and murine Kaposi's sarcoma-like cells PubMed
    tat HIV-1 Tat upregulates fibronectin expression in salivary gland cell lines, thymic epithelial cells, and glioblastoma cells PubMed
    retropepsin gag-pol The cell-associated protein fibronectin (A-chain) is specifically cleaved in vitro by HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

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      Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, organism-specific biosystemThis pathway Involved in chemo-resistance of cells in bladder cancer begins with LOXL2 activation of CDC37 and COL2A1. COL2A1 activates the complex NRF1/2 and two other complexes that trigger RTK/MAP...
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-2-mediated signaling events, organism-specific biosystem
      Syndecan-2-mediated signaling events
    • Syndecan-4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-4-mediated signaling events, organism-specific biosystem
      Syndecan-4-mediated signaling events
    • TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition, organism-specific biosystem (from WikiPathways)
      TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition, organism-specific biosystemThis pathway is based on the Figure 7 of "Cadherin 6 Is a New RUNX2 Target in TGF-? Signalling Pathway" (see bibliography). TGF-B is a target gene in thyroid cells in the causation of cancer. When TG...
    • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
      VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
    • VEGFR3 signaling in lymphatic endothelium, organism-specific biosystem (from Pathway Interaction Database)
      VEGFR3 signaling in lymphatic endothelium, organism-specific biosystem
      VEGFR3 signaling in lymphatic endothelium
    • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      amb2 Integrin signaling, organism-specific biosystem
      amb2 Integrin signaling
    • miRNA targets in ECM and membrane receptors, organism-specific biosystem (from WikiPathways)
      miRNA targets in ECM and membrane receptors, organism-specific biosystemBased on the KEGG ECM-receptor interactions pathway (hsa04512), a depiction a plausible mechanism, where miRNAs regulate components of both extracellular matrix (top panel) and transmembrane receptor...
    • p130Cas linkage to MAPK signaling for integrins, organism-specific biosystem (from REACTOME)
      p130Cas linkage to MAPK signaling for integrins, organism-specific biosystemIntegrin signaling is linked to the MAP kinase pathway by recruiting p130cas and Crk to the FAK/Src activation complex.
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp686H0342, DKFZp686I1370, DKFZp686F10164, DKFZp686O13149

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    collagen binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    heparin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    peptidase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-independent cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell-substrate junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    endodermal cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix disassembly TAS
    Traceable Author Statement
    more info
     
    extracellular matrix organization TAS
    Traceable Author Statement
    more info
     
    integrin activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interaction with other organism via secreted substance involved in symbiotic interaction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interaction with symbiont IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    negative regulation of transforming growth factor-beta secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide cross-linking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of substrate-dependent cell migration, cell attachment to substrate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to wounding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    basal lamina IEA
    Inferred from Electronic Annotation
    more info
     
    blood microparticle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibrinogen complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
     
    proteinaceous extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    fibronectin
    Names
    cold-insoluble globulin
    migration-stimulating factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012196.1 RefSeqGene

      Range
      5001..80629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306129.1NP_001293058.1  fibronectin isoform 8 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) contains a segment with an alternate splice structure in the 3' coding region, compared to variant 1. Isoform 8 encoded by this variant is shorter than isoform 1. The encoded isoform (8) may undergo proteolytic processing similar to isoform 3.
      Source sequence(s)
      AI033037, AJ535086, BC143754, BX537590, BX640803, BX640875, CA422234, CR749316, CR749317, DA851446
      Consensus CDS
      CCDS77526.1
      UniProtKB/Swiss-Prot
      P02751
      UniProtKB/TrEMBL
      B7ZLE5
      Related
      ENSP00000323534, OTTHUMP00000164054, ENST00000323926, OTTHUMT00000256668
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23542393
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    2. NM_001306130.1NP_001293059.1  fibronectin isoform 9 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. Isoform 9 encoded by this variant has a distinct internal amino acid and is shorter than isoform 1. The encoded isoform (9) may undergo proteolytic processing similar to isoform 3.
      Source sequence(s)
      AI033037, AJ535086, BC143754, BX640803, BX640875, CA422234, CR749316, CR749317, DA851446
      Consensus CDS
      CCDS77525.1
      UniProtKB/Swiss-Prot
      P02751
      UniProtKB/TrEMBL
      B7ZLE5
      Related
      ENSP00000399538, OTTHUMP00000206765, ENST00000432072, OTTHUMT00000337233
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21752214
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    3. NM_001306131.1NP_001293060.1  fibronectin isoform 10 precursor

      See identical proteins and their annotated locations for NP_001293060.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks two alternate in-frame exons in the central and 3' coding regions, and contains a segment with an alternate splice structure in the 3' coding region, compared to variant 1. Isoform 10 encoded by this variant has a distinct internal amino acid and is shorter than isoform 1. The encoded isoform (10) may undergo proteolytic processing similar to isoform 3.
      Source sequence(s)
      AI033037, AJ535086, BQ005645, BX640803, BX640875, BX640999, CR749281, CR749317, DA851446, U60068
      Consensus CDS
      CCDS77523.1
      UniProtKB/Swiss-Prot
      P02751
      UniProtKB/TrEMBL
      Q6MZM7, Q9UQS6
      Related
      ENSP00000415018, OTTHUMP00000206763, ENST00000443816, OTTHUMT00000337230
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21732212
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    4. NM_001306132.1NP_001293061.1  fibronectin isoform 11 precursor

      See identical proteins and their annotated locations for NP_001293061.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks two alternate in-frame exons in the central and 3' coding regions, and contains a segment with an alternate splice structure in the 3' coding region, compared to variant 1. Isoform 11 encoded by this variant has a distinct internal amino acid and is shorter than isoform 1. The encoded isoform (11) may undergo proteolytic processing similar to isoform 3.
      Source sequence(s)
      AI033037, AJ535086, BC143754, BX640803, BX640875, CA422234, CR749317, DA851446, U60068
      Consensus CDS
      CCDS77522.1
      UniProtKB/Swiss-Prot
      P02751
      UniProtKB/TrEMBL
      B7ZLE5, Q9UQS6
      Related
      ENSP00000394423, OTTHUMP00000206760, ENST00000421182, OTTHUMT00000337226
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21482187
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    5. NM_002026.3NP_002017.1  fibronectin isoform 3 preproprotein

      See identical proteins and their annotated locations for NP_002017.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon and an internal segment in the coding region, as compared to variant 1. Isoform 3 encoded by this variant thus lacks two internal segments, as compared to isoform 1.
      Source sequence(s)
      AI033037, AJ535086, BQ005645, BX640638, BX640731, BX640802, CR749317, X02761
      Consensus CDS
      CCDS2399.1
      UniProtKB/Swiss-Prot
      P02751
      UniProtKB/TrEMBL
      Q6MZF4, Q6N084
      Related
      ENSP00000338200, OTTHUMP00000164055, ENST00000336916, OTTHUMT00000256669
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22632302
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    6. NM_054034.2NP_473375.2  fibronectin isoform 7 preproprotein

      See identical proteins and their annotated locations for NP_473375.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks multiple 3' exons and has an alternate 3' end, as compared to variant 1. Isoform 7 encoded by this variant is much shorter and has a distinct C-terminus, as compared isoform 1.
      Source sequence(s)
      AJ276395, AJ535086, BX640608, BX640999
      Consensus CDS
      CCDS46512.1
      UniProtKB/Swiss-Prot
      P02751
      Related
      ENSP00000398907, OTTHUMP00000206767, ENST00000426059, OTTHUMT00000337235
      Conserved Domains (4) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:5289
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
    7. NM_212474.2NP_997639.1  fibronectin isoform 6 precursor

      See identical proteins and their annotated locations for NP_997639.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two in-frame exons and an in-frame segment in the coding region, as compared to variant 1. Isoform 6 encoded by this variant thus lacks three internal segments, as compared to isoform 1. The encoded isoform (6) may undergo proteolytic processing similar to isoform 3.
      Source sequence(s)
      AI033037, AJ535086, AL832202, BQ005645, CR749317, U60068, X02761
      Consensus CDS
      CCDS2400.1
      UniProtKB/Swiss-Prot
      P02751
      UniProtKB/TrEMBL
      Q9UQS6
      Related
      ENSP00000350534, OTTHUMP00000164056, ENST00000357867, OTTHUMT00000256670
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:20842123
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    8. NM_212476.2NP_997641.1  fibronectin isoform 5 precursor

      See identical proteins and their annotated locations for NP_997641.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two in-frame exons in the coding region, as compared to variant 1. Isoform 5 encoded by this variant thus lacks two internal segments, as compared to isoform 1. The encoded isoform (5) may undergo proteolytic processing similar to isoform 3.
      Source sequence(s)
      AI033037, AJ535086, BQ005645, BX640608, CR749317, U60068, X02761
      Consensus CDS
      CCDS42813.1
      UniProtKB/Swiss-Prot
      P02751
      UniProtKB/TrEMBL
      Q9UQS6
      Related
      ENSP00000348285, OTTHUMP00000206766, ENST00000356005, OTTHUMT00000337234
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22042243
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    9. NM_212478.2NP_997643.1  fibronectin isoform 4 precursor

      See identical proteins and their annotated locations for NP_997643.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon and two in-frame segments in the coding region, as compared to variant 1. Isoform 4 encoded by this variant thus lacks three internal segments, as compared to isoform 1. The encoded isoform (4) may undergo proteolytic processing similar to isoform 3.
      Source sequence(s)
      AI033037, AJ535086, BQ005645, BX640802, CR749317, U60068, X02761
      Consensus CDS
      CCDS46510.1
      UniProtKB/Swiss-Prot
      P02751
      UniProtKB/TrEMBL
      Q6MZF4, Q9UQS6
      Related
      ENSP00000410422, OTTHUMP00000206762, ENST00000446046, OTTHUMT00000337229
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22382277
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    10. NM_212482.2NP_997647.1  fibronectin isoform 1 precursor

      See identical proteins and their annotated locations for NP_997647.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). The encoded isoform (1) may undergo proteolytic processing similar to isoform 3.
      Source sequence(s)
      AI033037, AJ535086, BQ005645, BX640803, BX640875, BX640999, CR749317, U60068
      Consensus CDS
      CCDS42814.1
      UniProtKB/Swiss-Prot
      P02751
      UniProtKB/TrEMBL
      Q6MZM7, Q9UQS6
      Related
      ENSP00000346839, OTTHUMP00000164053, ENST00000354785, OTTHUMT00000256667
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23852424
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      215360440..215436167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005246412.1XP_005246469.1  fibronectin isoform X19

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21792218
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    2. XM_005246414.1XP_005246471.1  fibronectin isoform X20

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21742213
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    3. XM_005246409.1XP_005246466.1  fibronectin isoform X12

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22692308
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    4. XM_005246406.1XP_005246463.1  fibronectin isoform X9

      See identical proteins and their annotated locations for XP_005246463.1

      UniProtKB/Swiss-Prot
      P02751
      Related
      ENSP00000352696, ENST00000359671
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22942333
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    5. XM_017003694.1XP_016859183.1  fibronectin isoform X16

    6. XM_017003693.1XP_016859182.1  fibronectin isoform X14

    7. XM_005246405.1XP_005246462.1  fibronectin isoform X8

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22952334
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    8. XM_017003692.1XP_016859181.1  fibronectin isoform X13

    9. XM_005246402.1XP_005246459.1  fibronectin isoform X5

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23292368
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    10. XM_005246416.1XP_005246473.1  fibronectin isoform X21

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21482187
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    11. XM_017003695.1XP_016859184.1  fibronectin isoform X17

    12. XM_005246404.1XP_005246461.1  fibronectin isoform X7

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22942333
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    13. XM_005246411.1XP_005246468.1  fibronectin isoform X18

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21752214
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    14. XM_005246410.1XP_005246467.1  fibronectin isoform X15

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22392278
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    15. XM_005246408.1XP_005246465.1  fibronectin isoform X11

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22642303
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    16. XM_005246403.1XP_005246460.1  fibronectin isoform X6

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22952334
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    17. XM_005246407.1XP_005246464.1  fibronectin isoform X10

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22652304
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    18. XM_005246401.1XP_005246458.1  fibronectin isoform X4

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23292368
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    19. XM_005246398.1XP_005246455.1  fibronectin isoform X2

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23602399
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    20. XM_005246399.1XP_005246456.1  fibronectin isoform X3

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23542393
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    21. XM_005246397.1XP_005246454.1  fibronectin isoform X1

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23852424
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      216231063..216306652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_212475.1: Suppressed sequence

      Description
      NM_212475.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center