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    Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 [ Mus musculus (house mouse) ]

    Gene ID: 15567, updated on 23-May-2018
    Official Symbol
    Slc6a4provided by MGI
    Official Full Name
    solute carrier family 6 (neurotransmitter transporter, serotonin), member 4provided by MGI
    Primary source
    MGI:MGI:96285
    See related
    Ensembl:ENSMUSG00000020838 Vega:OTTMUSG00000006240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Htt; Sert; 5-HTT; AI323329
    Expression
    Broad expression in large intestine adult (RPKM 24.9), small intestine adult (RPKM 15.4) and 16 other tissues See more
    Orthologs
    See Slc6a4 in Genome Data Viewer
    Location:
    11 B5; 11 46.18 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (76998466..77032345)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (76812099..76845845)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene transmembrane and immunoglobulin domain containing 1 Neighboring gene bleomycin hydrolase Neighboring gene predicted gene 12343 Neighboring gene nuclear speckle regulatory protein 1 Neighboring gene microRNA 423 Neighboring gene EF-hand calcium binding domain 5 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC124313, MGC124314

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rab GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    cocaine binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    monoamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    myosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    neurotransmitter:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    nitric-oxide synthase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    serotonin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    serotonin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    serotonin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    serotonin:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    syntaxin-1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    brain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to cGMP ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to organic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    memory ISO
    Inferred from Sequence Orthology
    more info
     
    monoamine transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of cerebellar granule cell precursor proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of synaptic transmission, dopaminergic ISO
    Inferred from Sequence Orthology
    more info
     
    neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of serotonin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of thalamus size ISO
    Inferred from Sequence Orthology
    more info
     
    response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    serotonin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    serotonin transport ISO
    Inferred from Sequence Orthology
    more info
     
    serotonin uptake IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    serotonin uptake IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serotonin uptake IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    serotonin uptake ISO
    Inferred from Sequence Orthology
    more info
     
    social behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sperm ejaculation ISO
    Inferred from Sequence Orthology
    more info
     
    vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endomembrane system ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    sodium-dependent serotonin transporter
    Names
    5-hydroxytryptamine (serotonin) transporter
    5HT transporter
    5HTT
    Sodium-dependent serotonin transporter (5HT transporter) (5HTT)
    solute carrier family 6 member 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010484.2NP_034614.2  sodium-dependent serotonin transporter

      See identical proteins and their annotated locations for NP_034614.2

      Status: VALIDATED

      Source sequence(s)
      AL603842
      Consensus CDS
      CCDS25074.1
      UniProtKB/Swiss-Prot
      Q60857
      Related
      ENSMUSP00000021195.4, OTTMUSP00000006548, ENSMUST00000021195.10, OTTMUST00000014089
      Conserved Domains (2) summary
      cd11513
      Location:79615
      SLC6sbd_SERT; Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain
      pfam03491
      Location:2464
      5HT_transport_N; Serotonin (5-HT) neurotransmitter transporter, N-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      76998466..77032345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532302.1XP_006532365.1  sodium-dependent serotonin transporter isoform X2

      Conserved Domains (2) summary
      pfam03491
      Location:2464
      5HT_transport_N; Serotonin (5-HT) neurotransmitter transporter, N-terminus
      cl00456
      Location:79516
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_006532299.2XP_006532362.1  sodium-dependent serotonin transporter isoform X1

      See identical proteins and their annotated locations for XP_006532362.1

      UniProtKB/Swiss-Prot
      Q60857
      Conserved Domains (2) summary
      cd11513
      Location:79615
      SLC6sbd_SERT; Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain
      pfam03491
      Location:2464
      5HT_transport_N; Serotonin (5-HT) neurotransmitter transporter, N-terminus
    3. XM_006532300.2XP_006532363.1  sodium-dependent serotonin transporter isoform X1

      See identical proteins and their annotated locations for XP_006532363.1

      UniProtKB/Swiss-Prot
      Q60857
      Conserved Domains (2) summary
      cd11513
      Location:79615
      SLC6sbd_SERT; Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain
      pfam03491
      Location:2464
      5HT_transport_N; Serotonin (5-HT) neurotransmitter transporter, N-terminus
    4. XM_006532301.3XP_006532364.1  sodium-dependent serotonin transporter isoform X1

      See identical proteins and their annotated locations for XP_006532364.1

      UniProtKB/Swiss-Prot
      Q60857
      Conserved Domains (2) summary
      cd11513
      Location:79615
      SLC6sbd_SERT; Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain
      pfam03491
      Location:2464
      5HT_transport_N; Serotonin (5-HT) neurotransmitter transporter, N-terminus
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