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    Nos2 nitric oxide synthase 2, inducible [ Mus musculus (house mouse) ]

    Gene ID: 18126, updated on 9-May-2017
    Official Symbol
    Nos2provided by MGI
    Official Full Name
    nitric oxide synthase 2, inducibleprovided by MGI
    Primary source
    MGI:MGI:97361
    See related
    Ensembl:ENSMUSG00000020826 Vega:OTTMUSG00000000146
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    iNOS; Nos-2; Nos2a; i-NOS; NOS-II; MAC-NOS
    Summary
    Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase that is inducible by a combination of lipopolysaccharide and certain cytokines. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (78920787..78960232)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (78734361..78773626)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor binding protein 4 pseudogene Neighboring gene e3 SUMO-protein ligase NSE2-like Neighboring gene lectin, galactose binding, soluble 9 Neighboring gene predicted gene 11201 Neighboring gene kinase suppressor of ras 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Apelin signaling pathway, organism-specific biosystem (from KEGG)
      Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
    • Arginine and proline metabolism, organism-specific biosystem (from KEGG)
      Arginine and proline metabolism, organism-specific biosystem
      Arginine and proline metabolism
    • Arginine and proline metabolism, conserved biosystem (from KEGG)
      Arginine and proline metabolism, conserved biosystem
      Arginine and proline metabolism
    • Arginine biosynthesis, organism-specific biosystem (from KEGG)
      Arginine biosynthesis, organism-specific biosystem
      Arginine biosynthesis
    • Arginine biosynthesis, conserved biosystem (from KEGG)
      Arginine biosynthesis, conserved biosystem
      Arginine biosynthesis
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
      Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
      HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Nitric oxide stimulates guanylate cyclase, organism-specific biosystem (from REACTOME)
      Nitric oxide stimulates guanylate cyclase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Peroxisome, organism-specific biosystem (from KEGG)
      Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
    • Peroxisome, conserved biosystem (from KEGG)
      Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Platelet homeostasis, organism-specific biosystem (from REACTOME)
      Platelet homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • ROS, RNS production in phagocytes, organism-specific biosystem (from REACTOME)
      ROS, RNS production in phagocytes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process tha...
    • TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem (from LIPID MAPS)
      TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem
      TLR4 (Toll-like receptor 4) signaling pathway
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
      Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    FMN binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    NADPH-hemoprotein reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    arginine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP-dependent protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nitric-oxide synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nitric-oxide synthase binding ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    tetrahydrobiopterin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    arginine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    arginine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    interleukin-6 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-8 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    nitric oxide mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT ovulation from ovarian follicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-cysteine S-nitrosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of blood vessel diameter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of killing of cells of other organism ISO
    Inferred from Sequence Orthology
    more info
     
    prostaglandin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    superoxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    nitric oxide synthase, inducible
    Names
    NOS type II
    inducible NO synthase
    inducible NOS
    inducible nitric oxide synthase
    macrophage NOS
    nitric oxide synthase 2, inducible, macrophage
    peptidyl-cysteine S-nitrosylase NOS2
    NP_001300850.1
    NP_001300851.1
    NP_035057.1
    XP_006532509.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313921.1NP_001300850.1  nitric oxide synthase, inducible isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in place of the first two exons compared to variant 1. This difference results in translation initiation at a downstream start codon and an isoform (b) that is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AL592185, CJ057491, M87039
      UniProtKB/Swiss-Prot
      P29477
      UniProtKB/TrEMBL
      A0A1L1STZ4
      Conserved Domains (4) summary
      COG0369
      Location:4211008
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      cd00795
      Location:1377
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      pfam00258
      Location:422553
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:6171013
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    2. NM_001313922.1NP_001300851.1  nitric oxide synthase, inducible isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in place of the first two exons compared to variant 1. This difference results in translation initiation at a downstream start codon and an isoform (b) that is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AL592185, CN693247, M87039
      UniProtKB/Swiss-Prot
      P29477
      UniProtKB/TrEMBL
      A0A1L1STZ4
      Related
      ENSMUSP00000150558.1, OTTMUSP00000080892, ENSMUST00000214397.1, OTTMUST00000144992
      Conserved Domains (4) summary
      COG0369
      Location:4211008
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      cd00795
      Location:1377
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      pfam00258
      Location:422553
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:6171013
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    3. NM_010927.4NP_035057.1  nitric oxide synthase, inducible isoform a

      See identical proteins and their annotated locations for NP_035057.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL592185, M87039
      Consensus CDS
      CCDS25115.1
      UniProtKB/Swiss-Prot
      P29477
      Related
      ENSMUSP00000018610.6, OTTMUSP00000000202, ENSMUST00000018610.6, OTTMUST00000000466
      Conserved Domains (4) summary
      COG0369
      Location:5341121
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      cd00795
      Location:78490
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      pfam00258
      Location:535666
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:7301126
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      78920787..78960232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532446.3XP_006532509.1  nitric oxide synthase, inducible isoform X1

      Conserved Domains (4) summary
      COG0369
      Location:5331120
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      cd00795
      Location:77489
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      pfam00258
      Location:534665
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:7291125
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
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