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    YOS9 Yos9p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851627, updated on 5-Nov-2017
    Gene symbol
    YOS9
    Gene description
    Yos9p
    Primary source
    SGD:S000002464
    Locus tag
    YDR057W
    Gene type
    protein coding
    RNA name
    Yos9p
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (565927..567555)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pst1p Neighboring gene Emc10p Neighboring gene triglyceride lipase Neighboring gene tRNA

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    Products Interactant Other Gene Complex Source Pubs Description

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    oligosaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrograde protein transport, ER to cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent glycoprotein ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with Hrd1p ubiquitin ligase ERAD-L complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    luminal surveillance complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    Yos9p
    NP_010342.3
    • ER quality-control lectin; integral subunit of the HRD ligase; participates in efficient ER retention of misfolded proteins by recognizing them and delivering them to Hrd1p; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      565927..567555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180365.3NP_010342.3  TPA: Yos9p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010342.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q99220
      Conserved Domains (2) summary
      cd11745
      Location:277397
      Yos9_DD; C-terminal dimerization domain (DD) of Saccharomyces cerevisiae Yos9 and related proteins
      pfam07915
      Location:116193
      PRKCSH; Glucosidase II beta subunit-like protein
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