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    Gata2 GATA binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 14461, updated on 16-May-2017
    Official Symbol
    Gata2provided by MGI
    Official Full Name
    GATA binding protein 2provided by MGI
    Primary source
    MGI:MGI:95662
    See related
    Ensembl:ENSMUSG00000015053 Vega:OTTMUSG00000057342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gata-2
    Orthologs
    Location:
    6 D1; 6 39.2 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (88193437..88207032)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (88148658..88157026)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene ribophorin I Neighboring gene microRNA 6376 Neighboring gene predicted gene, 38708 Neighboring gene predicted gene, 38856 Neighboring gene DnaJ heat shock protein family (Hsp40) member B8 Neighboring gene eukaryotic elongation factor, selenocysteine-tRNA-specific

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC129339

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    C2H2 zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II distal enhancer sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enhancer sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    GABAergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation in hindbrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell fate determination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    commitment of neuronal cell to specific neuron type in forebrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eosinophil fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    homeostasis of number of cells within a tissue IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fat cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macrophage differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    pituitary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of megakaryocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of forebrain neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of histone acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of primitive erythrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    semicircular canal development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    urogenital system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventral spinal cord interneuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    endothelial transcription factor GATA-2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008090.5NP_032116.4  endothelial transcription factor GATA-2

      See identical proteins and their annotated locations for NP_032116.4

      Status: VALIDATED

      Source sequence(s)
      AB000096, AW492264, BC107009, BY132907
      Consensus CDS
      CCDS20333.1
      UniProtKB/Swiss-Prot
      O09100
      UniProtKB/TrEMBL
      Q3U320
      Related
      ENSMUSP00000015197.7, OTTMUSP00000073783, ENSMUST00000015197.8, OTTMUST00000141093
      Conserved Domains (2) summary
      smart00401
      Location:344393
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:349398
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      88193437..88207032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505539.3XP_006505602.1  endothelial transcription factor GATA-2 isoform X1

      See identical proteins and their annotated locations for XP_006505602.1

      UniProtKB/Swiss-Prot
      O09100
      UniProtKB/TrEMBL
      Q3U320
      Related
      ENSMUSP00000128198.1, OTTMUSP00000073781, ENSMUST00000170089.7, OTTMUST00000141091
      Conserved Domains (2) summary
      smart00401
      Location:344393
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:349398
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
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