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    HMGN1 high mobility group nucleosome binding domain 1 [ Homo sapiens (human) ]

    Gene ID: 3150, updated on 5-Nov-2017
    Official Symbol
    HMGN1provided by HGNC
    Official Full Name
    high mobility group nucleosome binding domain 1provided by HGNC
    Primary source
    HGNC:HGNC:4984
    See related
    Ensembl:ENSG00000205581 MIM:163920; Vega:OTTHUMG00000066178
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HMG14
    Summary
    The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in bone marrow (RPKM 44.3), lymph node (RPKM 41.2) and 25 other tissues See more
    Orthologs
    Location:
    21q22.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 21 NC_000021.9 (39342315..39349121, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (40714241..40721047, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene bromodomain and WD repeat domain containing 1 Neighboring gene BRWD1 antisense RNA 2 Neighboring gene BRWD1 antisense RNA 1 Neighboring gene uncharacterized LOC105372804 Neighboring gene WRB-SH3BGR readthrough Neighboring gene ring finger protein 6 pseudogene 1 Neighboring gene tryptophan rich basic protein

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat specifically associates with HMGN1 promoter to upregulate HMGN1 expression in T cells PubMed

    Go to the HIV-1, Human Interaction Database

    • ATM Signaling Network in Development and Disease, organism-specific biosystem (from WikiPathways)
      ATM Signaling Network in Development and Disease, organism-specific biosystemThis pathway is modeled after Figure 4 in the article "The ATM signaling network in development and disease" (See Bibliography). When DNA is damaged, DDR begins to work on recuperating the damage th...
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
    • Dual incision in TC-NER, organism-specific biosystem (from REACTOME)
      Dual incision in TC-NER, organism-specific biosystemIn transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), the oligonucleotide that contains the lesion is excised from the open bubbl...
    • Formation of TC-NER Pre-Incision Complex, organism-specific biosystem (from REACTOME)
      Formation of TC-NER Pre-Incision Complex, organism-specific biosystemFormation of TC-NER pre-incision complex is initiated when the RNA polymerase II (RNA Pol II) complex stalls at a DNA damage site. The stalling is caused by misincorporation of a ribonucleotide oppos...
    • Gap-filling DNA repair synthesis and ligation in TC-NER, organism-specific biosystem (from REACTOME)
      Gap-filling DNA repair synthesis and ligation in TC-NER, organism-specific biosystemIn transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), DNA polymerases delta or epsilon, or the Y family DNA polymerase kappa, fil...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
      Nucleotide Excision Repair, organism-specific biosystemNucleotide excision repair (NER) was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recove...
    • Transcription-Coupled Nucleotide Excision Repair (TC-NER), organism-specific biosystem (from REACTOME)
      Transcription-Coupled Nucleotide Excision Repair (TC-NER), organism-specific biosystemDNA damage in transcribed strands of active genes is repaired through a specialized nucleotide excision repair (NER) pathway known as transcription-coupled nucleotide excision repair (TC-NER). TC-NER...
    • p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ27265, FLJ31471, MGC104230, MGC117425

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleosomal DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA-templated transcription, elongation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of NAD+ ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    post-embryonic camera-type eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    pyrimidine dimer repair by nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of development, heterochronic IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    response to UV-B IEA
    Inferred from Electronic Annotation
    more info
     
    response to UV-C IEA
    Inferred from Electronic Annotation
    more info
     
    transcription-coupled nucleotide-excision repair TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    non-histone chromosomal protein HMG-14
    Names
    high mobility group nucleosome-binding domain-containing protein 1
    high-mobility group (nonhistone chromosomal) protein 14
    high-mobility group nucleosome binding 1
    nonhistone chromosomal protein HMG-14

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004965.6NP_004956.5  non-histone chromosomal protein HMG-14

      See identical proteins and their annotated locations for NP_004956.5

      Status: REVIEWED

      Source sequence(s)
      AL582106, BC070154, BE779939
      Consensus CDS
      CCDS33559.1
      UniProtKB/Swiss-Prot
      P05114
      UniProtKB/TrEMBL
      Q6NSG7
      Related
      ENSP00000370125.5, OTTHUMP00000068966, ENST00000380749.9, OTTHUMT00000141645
      Conserved Domains (1) summary
      pfam01101
      Location:194
      HMG14_17; HMG14 and HMG17

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p7 Primary Assembly

      Range
      39342315..39349121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529549.1XP_011527851.1  non-histone chromosomal protein HMG-14 isoform X1

      See identical proteins and their annotated locations for XP_011527851.1

    2. XM_017028336.1XP_016883825.1  non-histone chromosomal protein HMG-14 isoform X1

    3. XM_017028333.1XP_016883822.1  non-histone chromosomal protein HMG-14 isoform X1

    4. XM_011529544.1XP_011527846.1  non-histone chromosomal protein HMG-14 isoform X1

      See identical proteins and their annotated locations for XP_011527846.1

    5. XM_011529543.1XP_011527845.1  non-histone chromosomal protein HMG-14 isoform X1

      See identical proteins and their annotated locations for XP_011527845.1

    6. XM_017028332.1XP_016883821.1  non-histone chromosomal protein HMG-14 isoform X1

    7. XM_017028334.1XP_016883823.1  non-histone chromosomal protein HMG-14 isoform X1

    8. XM_011529547.1XP_011527849.1  non-histone chromosomal protein HMG-14 isoform X1

      See identical proteins and their annotated locations for XP_011527849.1

    9. XM_017028335.1XP_016883824.1  non-histone chromosomal protein HMG-14 isoform X1

    10. XM_011529545.1XP_011527847.1  non-histone chromosomal protein HMG-14 isoform X1

      See identical proteins and their annotated locations for XP_011527847.1

    11. XM_017028338.1XP_016883827.1  non-histone chromosomal protein HMG-14 isoform X2

    Alternate CHM1_1.1

    Genomic

    1. NC_018932.2 Alternate CHM1_1.1

      Range
      40275470..40282285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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