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    HST2 histone deacetylase HST2 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 856092, updated on 7-May-2017
    Gene symbol
    HST2
    Gene description
    histone deacetylase HST2
    Primary source
    SGD:S000005936
    Locus tag
    YPL015C
    Gene type
    protein coding
    RNA name
    histone deacetylase HST2
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See HST2 in Map Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (525810..526883, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Ctf19p Neighboring gene Irc15p Neighboring gene Swi1p Neighboring gene Cip1p Neighboring gene mitochondrial 37S ribosomal protein MRPS16

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD-dependent histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD-dependent histone deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chromatin silencing at rDNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chronological cell aging IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chronological cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of chromatin silencing at telomere IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mitotic recombination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of mitotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    histone deacetylase HST2
    NP_015310.1
    • Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      525810..526883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183829.1NP_015310.1  TPA: histone deacetylase HST2 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_015310.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53686
      Conserved Domains (1) summary
      cd01408
      Location:26277
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
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