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    Mbp myelin basic protein [ Mus musculus (house mouse) ]

    Gene ID: 17196, updated on 23-May-2017
    Official Symbol
    Mbpprovided by MGI
    Official Full Name
    myelin basic proteinprovided by MGI
    Primary source
    MGI:MGI:96925
    See related
    Ensembl:ENSMUSG00000041607 Vega:OTTMUSG00000016316
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    jve; mld; shi; Hmbpr; C76307; R75289; golli-mbp
    Summary
    The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    18 E3; 18 55.84 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (82475123..82585637)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (82644515..82755029)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene galanin receptor 1 Neighboring gene predicted gene, 30642 Neighboring gene ribosomal protein L21, pseudogene 8 Neighboring gene zinc finger protein 236 Neighboring gene predicted gene, 46620

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • MAPK Cascade, organism-specific biosystem (from WikiPathways)
      MAPK Cascade, organism-specific biosystemThe MAPK/ERK pathway is a signal transduction pathway that couples intracellular responses to the binding of growth factors to cell surface receptors. In many cell types, activation of this pathway p...
    • Mecp2 and Associated Rett Syndrome, organism-specific biosystem (from WikiPathways)
      Mecp2 and Associated Rett Syndrome, organism-specific biosystemMecp2 is in many mammals an important regulator of neuronal function and development. It affects all cell types, especially neurons but also astrocytes, oligodendrocytes, and glial cells. Mecp2 plays...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process tha...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    structural constituent of myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    maintenance of permeability of blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    membrane organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine (C-C motif) ligand 2 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-6 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    response to toxic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    compact myelin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    internode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    myelin basic protein; Golli-Mbp
    Names
    myelin A1 protein
    myelin deficient
    shiverer

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025245.1NP_001020416.1  Golli-Mbp isoform 2

      See identical proteins and their annotated locations for NP_001020416.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) contains 3 exons unique to Golli-Mbp and exon 1 of the classic Mbp. It encodes the shorter of the Golli-Mbp isoforms (2).
      Source sequence(s)
      AC117825, AK039047, AK040716
      Consensus CDS
      CCDS29374.1
      UniProtKB/Swiss-Prot
      P04370
      UniProtKB/TrEMBL
      Q5D096
      Related
      ENSMUSP00000089393.4, OTTMUSP00000017515, ENSMUST00000091789.10, OTTMUST00000039210
      Conserved Domains (1) summary
      pfam01669
      Location:147193
      Myelin_MBP; Myelin basic protein
    2. NM_001025251.2NP_001020422.1  myelin basic protein isoform 1

      See identical proteins and their annotated locations for NP_001020422.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest of the classic Mbp isoforms (1).
      Source sequence(s)
      AC119259, BF457157, BY245551, CO425201
      Consensus CDS
      CCDS29376.1
      UniProtKB/Swiss-Prot
      P04370
      Related
      ENSMUSP00000053495.7, ENSMUST00000062446.13
      Conserved Domains (1) summary
      pfam01669
      Location:14194
      Myelin_MBP; Myelin basic protein
    3. NM_001025254.2NP_001020425.1  myelin basic protein isoform 2

      See identical proteins and their annotated locations for NP_001020425.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks exon 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (2) that is missing a 11 aa segment compared to isoform 1.
      Source sequence(s)
      BB633793, BC004704
      Consensus CDS
      CCDS37875.1
      UniProtKB/Swiss-Prot
      P04370
      Related
      ENSMUSP00000110322.3, ENSMUST00000114674.9
      Conserved Domains (1) summary
      pfam01669
      Location:14183
      Myelin_MBP; Myelin basic protein
    4. NM_001025255.2NP_001020426.1  myelin basic protein isoform 3

      See identical proteins and their annotated locations for NP_001020426.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks exon 2 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (3) that is missing a 26 aa segment compared to isoform 1.
      Source sequence(s)
      AC119259, BY245551, CK623660
      Consensus CDS
      CCDS29377.1
      UniProtKB/Swiss-Prot
      P04370
      Related
      ENSMUSP00000099876.4, ENSMUST00000102812.10
      Conserved Domains (1) summary
      pfam01669
      Location:14168
      Myelin_MBP; Myelin basic protein
    5. NM_001025256.2NP_001020427.1  myelin basic protein isoform 4

      See identical proteins and their annotated locations for NP_001020427.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks exon 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (4) that is missing a 41 aa segment compared to isoform 1.
      Source sequence(s)
      AC119259, AK079621, BY245551
      Consensus CDS
      CCDS29378.1
      UniProtKB/Swiss-Prot
      P04370
      UniProtKB/TrEMBL
      Q542T4
      Related
      ENSMUSP00000079488.4, ENSMUST00000080658.10
      Conserved Domains (1) summary
      pfam01669
      Location:14148
      Myelin_MBP; Myelin basic protein
    6. NM_001025258.2NP_001020429.1  myelin basic protein isoform 5

      See identical proteins and their annotated locations for NP_001020429.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks exons 2 and 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (5) that is missing a 26 aa and a 11 aa segment compared to isoform 1.
      Source sequence(s)
      AC119259, BY245551, M15062
      Consensus CDS
      CCDS29379.1
      UniProtKB/Swiss-Prot
      P04370
      Related
      ENSMUSP00000074836.5, ENSMUST00000075372.11
      Conserved Domains (1) summary
      pfam01669
      Location:14157
      Myelin_MBP; Myelin basic protein
    7. NM_001025259.2NP_001020430.1  myelin basic protein isoform 6

      See identical proteins and their annotated locations for NP_001020430.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks exons 2 and 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (6) that is missing a 26 aa and a 41 aa segment compared to isoform 1.
      Source sequence(s)
      AC119259, AK005129, BY245551
      UniProtKB/Swiss-Prot
      P04370
      UniProtKB/TrEMBL
      Q3UGF3
      Related
      ENSMUSP00000116019.1, OTTMUSP00000022344, ENSMUST00000133193.7, OTTMUST00000048639
      Conserved Domains (1) summary
      pfam01669
      Location:14122
      Myelin_MBP; Myelin basic protein
    8. NM_010777.3NP_034907.1  Golli-Mbp isoform 1

      See identical proteins and their annotated locations for NP_034907.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains 3 exons unique to Golli-Mbp and exons 1, 3, 4 and 7 of the classic Mbp. It encodes the longer of the Golli-Mbp isoforms (1).
      Source sequence(s)
      AC117825, AC119259, L07507
      Consensus CDS
      CCDS29373.1
      UniProtKB/Swiss-Prot
      P04370
      Related
      ENSMUSP00000046185.7, OTTMUSP00000017514, ENSMUST00000047865.13, OTTMUST00000039208
      Conserved Domains (1) summary
      pfam01669
      Location:147249
      Myelin_MBP; Myelin basic protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      82475123..82585637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526454.2XP_006526517.1  Golli-Mbp isoform X3

      Conserved Domains (1) summary
      pfam01669
      Location:147323
      Myelin_MBP; Myelin basic protein
    2. XM_006526456.2XP_006526519.1  Golli-Mbp isoform X5

      Conserved Domains (1) summary
      pfam01669
      Location:147301
      Myelin_MBP; Myelin basic protein
    3. XM_006526458.2XP_006526521.1  Golli-Mbp isoform X7

      Conserved Domains (1) summary
      pfam01669
      Location:147255
      Myelin_MBP; Myelin basic protein
    4. XM_006526452.3XP_006526515.1  Golli-Mbp isoform X1

      Conserved Domains (1) summary
      pfam01669
      Location:147349
      Myelin_MBP; Myelin basic protein
    5. XM_006526455.1XP_006526518.1  Golli-Mbp isoform X4

      Conserved Domains (1) summary
      pfam01669
      Location:147308
      Myelin_MBP; Myelin basic protein
    6. XM_006526453.2XP_006526516.1  Golli-Mbp isoform X2

      Conserved Domains (1) summary
      pfam01669
      Location:147327
      Myelin_MBP; Myelin basic protein
    7. XM_006526457.2XP_006526520.1  Golli-Mbp isoform X6

      See identical proteins and their annotated locations for XP_006526520.1

      Conserved Domains (1) summary
      pfam01669
      Location:147281
      Myelin_MBP; Myelin basic protein
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