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    Rbp4 retinol binding protein 4, plasma [ Mus musculus (house mouse) ]

    Gene ID: 19662, updated on 3-Apr-2018
    Official Symbol
    Rbp4provided by MGI
    Official Full Name
    retinol binding protein 4, plasmaprovided by MGI
    Primary source
    MGI:MGI:97879
    See related
    Ensembl:ENSMUSG00000024990
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rbp-4
    Expression
    Biased expression in liver adult (RPKM 1256.0), liver E18 (RPKM 733.2) and 6 other tissues See more
    Orthologs
    See Rbp4 in Genome Data Viewer
    Location:
    19 C2; 19 32.75 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (38116620..38125321, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (38191110..38199811, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene centrosomal protein 55 Neighboring gene free fatty acid receptor 4 Neighboring gene predicted gene, 32440 Neighboring gene phosphodiesterase 6C, cGMP specific, cone, alpha prime Neighboring gene FRA10AC1 homolog (human)

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    retinal binding IEA
    Inferred from Electronic Annotation
    more info
     
    retinoid binding IEA
    Inferred from Electronic Annotation
    more info
     
    retinol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retinol binding ISO
    Inferred from Sequence Orthology
    more info
     
    retinol transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of light stimulus involved in visual perception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic retina morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eye development ISO
    Inferred from Sequence Orthology
    more info
     
    female genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart trabecula formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of gastrointestinal epithelium ISO
    Inferred from Sequence Orthology
    more info
     
    male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of immunoglobulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    response to insulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinal metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    retinol transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    retinol transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinol transport ISO
    Inferred from Sequence Orthology
    more info
     
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    urinary bladder development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    uterus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vagina development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vitamin A import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    retinol-binding protein 4
    Names
    PRBP
    RBP
    plasma retinol-binding protein
    retinol binding protein 4, cellular

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159487.1NP_001152959.1  retinol-binding protein 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC101774, AK008765, AW113115, BY769772
      Consensus CDS
      CCDS50430.1
      UniProtKB/Swiss-Prot
      Q00724
      UniProtKB/TrEMBL
      H7BWY6
      Related
      ENSMUSP00000025951.6, ENSMUST00000025951.12
      Conserved Domains (1) summary
      pfam00061
      Location:83221
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    2. NM_011255.3NP_035385.1  retinol-binding protein 4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_035385.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK008765, AW113115, BY112174
      Consensus CDS
      CCDS29784.1
      UniProtKB/Swiss-Prot
      Q00724
      Related
      ENSMUSP00000107954.2, ENSMUST00000112335.2
      Conserved Domains (1) summary
      pfam00061
      Location:39177
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      38116620..38125321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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