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    Wfs1 wolframin ER transmembrane glycoprotein [ Mus musculus (house mouse) ]

    Gene ID: 22393, updated on 22-Apr-2017
    Official Symbol
    Wfs1provided by MGI
    Official Full Name
    wolframin ER transmembrane glycoproteinprovided by MGI
    Primary source
    MGI:MGI:1328355
    See related
    Ensembl:ENSMUSG00000039474 Vega:OTTMUSG00000035647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI481085; wolframin
    Orthologs
    Location:
    5; 5 B3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (36966104..36988982, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (37357343..37380221, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene mannosidase 2, alpha B2 Neighboring gene protein phosphatase 2, regulatory subunit B, gamma, opposite strand Neighboring gene protein phosphatase 2, regulatory subunit B, gamma Neighboring gene janus kinase and microtubule interacting protein 1 Neighboring gene isocitrate dehydrogenase 3 (NAD+) beta pseudogene Neighboring gene predicted gene 1043

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ATF6-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of type B pancreatic cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of type B pancreatic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    neurological system process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of adenylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
     
    positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    renal water homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    visual perception ISO
    Inferred from Sequence Orthology
    more info
     
    visual perception NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    wolframin
    Names
    Wolfram syndrome 1 homolog
    Wolfram syndrome 1 protein homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011716.2NP_035846.1  wolframin

      See identical proteins and their annotated locations for NP_035846.1

      Status: VALIDATED

      Source sequence(s)
      AC115722, AK144561, BY063019, BY296480, CX562372
      Consensus CDS
      CCDS19245.1
      UniProtKB/Swiss-Prot
      P56695
      UniProtKB/TrEMBL
      Q3TDI2, Q3UN10
      Related
      ENSMUSP00000048053.6, OTTMUSP00000050236, ENSMUST00000043964.12, OTTMUST00000091241
      Conserved Domains (1) summary
      pfam09971
      Location:401591
      DUF2206; Predicted membrane protein (DUF2206)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      36966104..36988982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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