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    NCOA3 nuclear receptor coactivator 3 [ Homo sapiens (human) ]

    Gene ID: 8202, updated on 6-Jun-2017
    Official Symbol
    NCOA3provided by HGNC
    Official Full Name
    nuclear receptor coactivator 3provided by HGNC
    Primary source
    HGNC:HGNC:7670
    See related
    Ensembl:ENSG00000124151 MIM:601937; Vega:OTTHUMG00000033061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
    Summary
    The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
    Orthologs
    Location:
    20q13.12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (47501857..47656877)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (46130601..46285621)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 497, pseudogene Neighboring gene RNA, U6 small nuclear 563, pseudogene Neighboring gene ribosomal protein S3A pseudogene Neighboring gene sulfatase 2 Neighboring gene uncharacterized LOC107985401 Neighboring gene RNA, U7 small nuclear 173 pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
    NHGRI GWA Catalog
    Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of nuclear receptor coactivator 3 (NCOA3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat NCOA3 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
    tat p/CIP binds to HIV-1 Tat and enhances Tat-stimulated HIV-1 LTR promoter transactivation PubMed
    tat HIV-1 Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 co-activators and the P-TEFb complex PubMed
    nucleocapsid gag Nuclear receptor coactivator 3 (NCOA3) is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Activation of HOX genes during differentiation, organism-specific biosystem (from REACTOME)
      Activation of HOX genes during differentiation, organism-specific biosystemHox genes encode proteins that contain the DNA-binding homeobox motif and control early patterning of segments in the embryo as well as later events in development (reviewed in Rezsohazy et al. 2015)...
    • Activation of anterior HOX genes in hindbrain development during early embryogenesis, organism-specific biosystem (from REACTOME)
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    • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
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    • Breast cancer, conserved biosystem (from KEGG)
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    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
    • Endocrine resistance, organism-specific biosystem (from KEGG)
      Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
    • Endocrine resistance, conserved biosystem (from KEGG)
      Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
    • FOXA1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      FOXA1 transcription factor network, organism-specific biosystem
      FOXA1 transcription factor network
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
      MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
    • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
      MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
      PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
    • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    • Retinoic acid receptors-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
      Retinoic acid receptors-mediated signaling, organism-specific biosystem
      Retinoic acid receptors-mediated signaling
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
      Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
    • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC141848

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    androgen receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ligand-dependent nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ligand-dependent nuclear receptor transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nuclear hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thyroid hormone receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    androgen receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cellular response to estradiol stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    histone acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    receptor transactivation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of RNA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Preferred Names
    nuclear receptor coactivator 3
    Names
    CBP-interacting protein
    amplified in breast cancer 1 protein
    class E basic helix-loop-helix protein 42
    receptor-associated coactivator 3
    steroid receptor coactivator protein 3
    thyroid hormone receptor activator molecule 1
    NP_001167558.1
    NP_001167559.1
    NP_006525.2
    NP_858045.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016810.1 RefSeqGene

      Range
      5001..160021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001174087.1NP_001167558.1  nuclear receptor coactivator 3 isoform c

      See identical proteins and their annotated locations for NP_001167558.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (c) compared to isoform a.
      Source sequence(s)
      AB209863, AL034418, DB091786
      UniProtKB/TrEMBL
      Q59EE8
      Conserved Domains (9) summary
      smart00353
      Location:3488
      HLH; helix loop helix domain
      smart00091
      Location:116173
      PAS; PAS domain
      pfam00989
      Location:117215
      PAS; PAS fold
      pfam07469
      Location:12901347
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10451092
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:620704
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:265375
      PAS_11; PAS domain
      pfam16279
      Location:723810
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:459572
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    2. NM_001174088.1NP_001167559.1  nuclear receptor coactivator 3 isoform d

      See identical proteins and their annotated locations for NP_001167559.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses three alternate in-frame splice sites compared to variant 1, resulting in a shorter isoform (d) compared to isoform a.
      Source sequence(s)
      AF036892, AL034418, DB091786
      Consensus CDS
      CCDS54472.1
      UniProtKB/Swiss-Prot
      Q9Y6Q9
      Related
      ENSP00000361065.3, OTTHUMP00000031717, ENST00000371997.3, OTTHUMT00000080404
      Conserved Domains (9) summary
      smart00353
      Location:3488
      HLH; helix loop helix domain
      smart00091
      Location:116173
      PAS; PAS domain
      pfam00989
      Location:117215
      PAS; PAS fold
      pfam07469
      Location:12821339
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10401087
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:630714
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:265385
      PAS_11; PAS domain
      pfam16279
      Location:733820
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:469582
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    3. NM_006534.3NP_006525.2  nuclear receptor coactivator 3 isoform b

      See identical proteins and their annotated locations for NP_006525.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
      Source sequence(s)
      AF012108, AL034418, DB091786
      Consensus CDS
      CCDS13406.1
      UniProtKB/Swiss-Prot
      Q9Y6Q9
      Related
      ENSP00000361073.1, OTTHUMP00000031716, ENST00000372004.7, OTTHUMT00000080403
      Conserved Domains (9) summary
      smart00353
      Location:3488
      HLH; helix loop helix domain
      smart00091
      Location:116173
      PAS; PAS domain
      pfam00989
      Location:117215
      PAS; PAS fold
      pfam07469
      Location:12871344
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10451092
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:620704
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:265375
      PAS_11; PAS domain
      pfam16279
      Location:723810
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:459572
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    4. NM_181659.2NP_858045.1  nuclear receptor coactivator 3 isoform a

      See identical proteins and their annotated locations for NP_858045.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AF016031, AL034418, DB091786
      Consensus CDS
      CCDS13407.1
      UniProtKB/Swiss-Prot
      Q9Y6Q9
      Related
      ENSP00000361066.3, OTTHUMP00000031718, ENST00000371998.7, OTTHUMT00000080405
      Conserved Domains (9) summary
      smart00353
      Location:3488
      HLH; helix loop helix domain
      smart00091
      Location:116173
      PAS; PAS domain
      pfam00989
      Location:117215
      PAS; PAS fold
      pfam07469
      Location:12911348
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:10451092
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:620704
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:265375
      PAS_11; PAS domain
      pfam16279
      Location:723810
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:459572
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      Range
      47501857..47656877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      46033477..46188916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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