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    Sema4b sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B [ Mus musculus (house mouse) ]

    Gene ID: 20352, updated on 3-Apr-2017
    Official Symbol
    Sema4bprovided by MGI
    Official Full Name
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Bprovided by MGI
    Primary source
    MGI:MGI:107559
    See related
    Ensembl:ENSMUSG00000030539 Vega:OTTMUSG00000021122
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SemC; Semac; mKIAA1745
    Orthologs
    Location:
    7; 7 D2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (80186841..80226646)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (87331727..87371410)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 710 Neighboring gene predicted gene, 21057 Neighboring gene isocitrate dehydrogenase 2 (NADP+), mitochondrial Neighboring gene calcium and integrin binding 1 (calmyrin) Neighboring gene GDP-D-glucose phosphorylase 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...

    Markers

    Homology

    Clone Names

    • KIAA1745

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    semaphorin-4B
    Names
    sema C
    semaphorin-C

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013659.4NP_038687.2  semaphorin-4B precursor

      See identical proteins and their annotated locations for NP_038687.2

      Status: VALIDATED

      Source sequence(s)
      AC109232, AK145570
      Consensus CDS
      CCDS21391.1
      UniProtKB/Swiss-Prot
      Q62179
      Related
      ENSMUSP00000032754.7, OTTMUSP00000023270, ENSMUST00000032754.8, OTTMUST00000050002
      Conserved Domains (3) summary
      cd05872
      Location:579663
      Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
      pfam01437
      Location:512558
      PSI; Plexin repeat
      cl15693
      Location:48511
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      80186841..80226646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250830.2XP_011249132.1  semaphorin-4B isoform X1

      See identical proteins and their annotated locations for XP_011249132.1

      UniProtKB/Swiss-Prot
      Q62179
      Related
      ENSMUSP00000145622.1, OTTMUSP00000075080, ENSMUST00000205822.1, OTTMUST00000143999
      Conserved Domains (3) summary
      cd05872
      Location:579663
      Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
      pfam01437
      Location:512558
      PSI; Plexin repeat
      cl15693
      Location:48511
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
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