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    Adora2a adenosine A2a receptor [ Mus musculus (house mouse) ]

    Gene ID: 11540, updated on 19-Nov-2017
    Official Symbol
    Adora2aprovided by MGI
    Official Full Name
    adenosine A2a receptorprovided by MGI
    Primary source
    MGI:MGI:99402
    See related
    Ensembl:ENSMUSG00000020178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A2aR; A2AAR; AA2AR
    Orthologs
    Location:
    10; 10 C1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (75316862..75334792)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (74779688..74797533)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene breakpoint cluster region Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1-like Neighboring gene ATP synthase subunit f, mitochondrial pseudogene Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene predicted gene, 40694

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC118414

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein coupled adenosine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled adenosine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    G-protein coupled adenosine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    type 5 metabotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenosine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenosine receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    adenosine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenosine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-activating G-protein coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    eating behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    inhibitory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of alpha-beta T cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of locomotion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of acetylcholine secretion, neurotransmission ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cAMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of circadian sleep/wake cycle, sleep ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of renal sodium excretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission, GABAergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of synaptic transmission, GABAergic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of urine volume ISO
    Inferred from Sequence Orthology
    more info
     
    prepulse inhibition ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of norepinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    response to alkaloid ISO
    Inferred from Sequence Orthology
    more info
     
    response to amphetamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to caffeine ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission, cholinergic ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic transmission, dopaminergic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    axolemma ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    endomembrane system ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with intermediate filament ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331095.1NP_001318024.1  adenosine receptor A2a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC137067
      Consensus CDS
      CCDS23924.1
      UniProtKB/Swiss-Prot
      Q60613
    2. NM_001331096.1NP_001318025.1  adenosine receptor A2a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC137067
      Consensus CDS
      CCDS23924.1
      UniProtKB/Swiss-Prot
      Q60613
    3. NM_009630.3NP_033760.2  adenosine receptor A2a

      See identical proteins and their annotated locations for NP_033760.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC137067, AK037787, BC110692, BY349524, CX241487
      Consensus CDS
      CCDS23924.1
      UniProtKB/Swiss-Prot
      Q60613
      UniProtKB/TrEMBL
      Q8CAU3
      Related
      ENSMUSP00000101060.1, ENSMUST00000105420.2
      Conserved Domains (2) summary
      pfam00001
      Location:20283
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:12132
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      75316862..75334792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513093.3XP_006513156.1  adenosine receptor A2a isoform X1

      See identical proteins and their annotated locations for XP_006513156.1

      UniProtKB/Swiss-Prot
      Q60613
      Conserved Domains (2) summary
      pfam00001
      Location:20283
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:12132
      7tm_4; Olfactory receptor
    2. XM_006513092.2XP_006513155.1  adenosine receptor A2a isoform X1

      Conserved Domains (2) summary
      pfam00001
      Location:20283
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:12132
      7tm_4; Olfactory receptor
    3. XM_006513094.1XP_006513157.1  adenosine receptor A2a isoform X1

      Conserved Domains (2) summary
      pfam00001
      Location:20283
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:12132
      7tm_4; Olfactory receptor
    4. XM_006513096.1XP_006513159.1  adenosine receptor A2a isoform X2

      Conserved Domains (1) summary
      pfam00001
      Location:2168
      7tm_1; 7 transmembrane receptor (rhodopsin family)
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