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    Lhx1 LIM homeobox protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 16869, updated on 19-Jun-2018
    Official Symbol
    Lhx1provided by MGI
    Official Full Name
    LIM homeobox protein 1provided by MGI
    Primary source
    MGI:MGI:99783
    See related
    Ensembl:ENSMUSG00000018698 Vega:OTTMUSG00000000972
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lim1
    Expression
    Biased expression in whole brain E14.5 (RPKM 11.5), CNS E11.5 (RPKM 10.7) and 5 other tissues See more
    Orthologs
    See Lhx1 in Genome Data Viewer
    Location:
    11 C; 11 51.31 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (84519379..84525534, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (84332881..84339036, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene acetyl-Coenzyme A carboxylase alpha Neighboring gene 60S ribosomal protein L35 pseudogene Neighboring gene uncharacterized LOC108167915 Neighboring gene apoptosis antagonizing transcription factor Neighboring gene LIM homeobox 1, opposite strand Neighboring gene RIKEN cDNA 1700109G15 gene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    S-shaped body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anatomical structure formation involved in morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    anatomical structure formation involved in morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anatomical structure morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterior/posterior axis specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    branching involved in ureteric bud morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cerebellar Purkinje cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cerebellum development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cervix development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    comma-shaped body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ectoderm formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic retina morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    forebrain regionalization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    head development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    horizontal cell localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lateral motor column neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesonephros development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    metanephric S-shaped body morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    metanephric renal vesicle morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    metanephros development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nephric duct elongation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nephric duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    oviduct development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oviduct epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    paramesonephric duct development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pattern specification process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of anterior head development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nephron tubule epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    primitive streak formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pronephros development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    renal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    renal vesicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retina development in camera-type eye IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    retina layer formation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    retina layer formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somite rostral/caudal axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spinal cord association neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    spinal cord development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    telencephalon development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    urogenital system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    uterine epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    uterus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vagina development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventral spinal cord development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    LIM/homeobox protein Lhx1
    Names
    LIM homeo box protein 1
    homeobox protein Lim-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008498.3NP_032524.1  LIM/homeobox protein Lhx1

      See identical proteins and their annotated locations for NP_032524.1

      Status: VALIDATED

      Source sequence(s)
      AL603708
      Consensus CDS
      CCDS25187.1
      UniProtKB/Swiss-Prot
      P63006
      UniProtKB/TrEMBL
      Q569N5
      Related
      ENSMUSP00000018842.6, OTTMUSP00000000925, ENSMUST00000018842.13
      Conserved Domains (4) summary
      cd09367
      Location:455
      LIM1_Lhx1_Lhx5; The first LIM domain of Lhx1 (also known as Lim1) and Lhx5
      cd09375
      Location:63118
      LIM2_Lhx1_Lhx5; The second LIM domain of Lhx1 (also known as Lim1) and Lhx5
      pfam00046
      Location:183236
      Homeobox; Homeobox domain
      cl28271
      Location:263382
      dnaA; chromosomal replication initiation protein; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      84519379..84525534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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