Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Cd46 CD46 antigen, complement regulatory protein [ Mus musculus (house mouse) ]

    Gene ID: 17221, updated on 27-Jan-2018
    Official Symbol
    Cd46provided by MGI
    Official Full Name
    CD46 antigen, complement regulatory proteinprovided by MGI
    Primary source
    MGI:MGI:1203290
    See related
    Ensembl:ENSMUSG00000016493 Vega:OTTMUSG00000034956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mcp
    Expression
    Broad expression in CNS E18 (RPKM 1.4), cortex adult (RPKM 1.4) and 23 other tissues See more
    Orthologs
    See Cd46 in Genome Data Viewer
    Location:
    1 H6; 1 98.41 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (195038971..195098784, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (196868094..196918442, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330023F24 gene Neighboring gene microRNA 29b-2 Neighboring gene microRNA 29c Neighboring gene complement component (3b/4b) receptor 1-like Neighboring gene predicted gene, 32313 Neighboring gene complement receptor 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    complement binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of memory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transforming growth factor beta production ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    sequestering of extracellular ligand from receptor ISO
    Inferred from Sequence Orthology
    more info
     
    single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    inner acrosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010778.4NP_034908.1  membrane cofactor protein precursor

      See identical proteins and their annotated locations for NP_034908.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the protein.
      Source sequence(s)
      AB010919, AC139206, AK006632, BE634816
      Consensus CDS
      CCDS35828.1
      UniProtKB/Swiss-Prot
      O88174
      Related
      ENSMUSP00000123931.1, OTTMUSP00000048501, ENSMUST00000162650.7, OTTMUST00000088873
      Conserved Domains (2) summary
      cd00033
      Location:239294
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:109168
      Sushi; Sushi repeat (SCR repeat)

    RNA

    1. NR_132621.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB010919, AC139206, AK006632, BE634816

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      195038971..195098784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497239.3XP_006497302.1  membrane cofactor protein isoform X5

      Conserved Domains (2) summary
      cd00033
      Location:173235
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:109168
      Sushi; Sushi repeat (SCR repeat)
    2. XM_006497236.1XP_006497299.1  membrane cofactor protein isoform X3

      See identical proteins and their annotated locations for XP_006497299.1

      Conserved Domains (2) summary
      cd00033
      Location:186241
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:56115
      Sushi; Sushi repeat (SCR repeat)
    3. XM_011238929.2XP_011237231.1  membrane cofactor protein isoform X4

      Conserved Domains (2) summary
      cd00033
      Location:173235
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:109168
      Sushi; Sushi repeat (SCR repeat)
    4. XM_006497235.3XP_006497298.1  membrane cofactor protein isoform X2

      Related
      ENSMUSP00000123901.1, OTTMUSP00000048502, ENSMUST00000159563.7, OTTMUST00000088874
      Conserved Domains (2) summary
      cd00033
      Location:239294
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:109168
      Sushi; Sushi repeat (SCR repeat)
    5. XM_006497234.3XP_006497297.1  membrane cofactor protein isoform X1

      Conserved Domains (2) summary
      cd00033
      Location:239294
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:109168
      Sushi; Sushi repeat (SCR repeat)
    6. XM_006497237.3XP_006497300.1  membrane cofactor protein isoform X3

      See identical proteins and their annotated locations for XP_006497300.1

      Conserved Domains (2) summary
      cd00033
      Location:186241
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:56115
      Sushi; Sushi repeat (SCR repeat)
    7. XM_011238930.2XP_011237232.1  membrane cofactor protein isoform X6

      Conserved Domains (2) summary
      cd00033
      Location:173235
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:109168
      Sushi; Sushi repeat (SCR repeat)

    RNA

    1. XR_373888.3 RNA Sequence

    2. XR_001783154.1 RNA Sequence

    3. XR_373889.3 RNA Sequence

    Support Center