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    Gja1 gap junction protein, alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24392, updated on 20-Jun-2017
    Official Symbol
    Gja1provided by RGD
    Official Full Name
    gap junction protein, alpha 1provided by RGD
    Primary source
    RGD:2690
    See related
    Ensembl:ENSRNOG00000000805
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cx43
    Summary
    gap junction component; plays a role in cell-cell communication [RGD, Feb 2006]
    Orthologs
    Location:
    20q11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (37876650..37889097)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (39612080..39624555)

    Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 32 Neighboring gene male-specific lethal 3-like 2 (Drosophila) Neighboring gene inactive serine/threonine-protein kinase VRK3 pseudogene Neighboring gene similar to L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M) Neighboring gene 60S ribosomal protein L15-like

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC93610

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    connexin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    gap junction channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gap junction channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    gap junction channel activity involved in cell communication by electrical coupling IEA
    Inferred from Electronic Annotation
    more info
     
    gap junction channel activity involved in cell communication by electrical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    ATP transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adult heart development ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    atrial ventricular junction remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    cell communication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell communication by chemical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    cell communication by electrical coupling IEA
    Inferred from Electronic Annotation
    more info
     
    cell communication by electrical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to pH ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to parathyroid hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    chronic inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    decidualization IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic heart tube development ISO
    Inferred from Sequence Orthology
    more info
     
    endothelium development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    epididymis development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    epithelial cell maturation ISO
    Inferred from Sequence Orthology
    more info
     
    gap junction assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    heart development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    heart looping ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    lens development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    milk ejection reflex ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of blood vessel diameter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell communication by chemical coupling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of striated muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein oligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of atrial cardiac muscle cell membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of bicellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of bone remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ventricular cardiac muscle cell membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ventricular cardiac muscle cell membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    response to fluid shear stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ischemia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal muscle tissue regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vascular transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    Golgi-associated vesicle membrane TAS
    Traceable Author Statement
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    connexin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    connexin complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contractile fiber ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    fascia adherens IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fascia adherens ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    gap junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gap junction ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    intermediate filament ISO
    Inferred from Sequence Orthology
    more info
     
    late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    multivesicular body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    protein complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Preferred Names
    gap junction alpha-1 protein
    Names
    connexin 43
    gap junction 43 kDa heart protein
    gap junction membrane channel protein alpha 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012567.2NP_036699.1  gap junction alpha-1 protein

      See identical proteins and their annotated locations for NP_036699.1

      Status: PROVISIONAL

      Source sequence(s)
      AY324140
      UniProtKB/Swiss-Prot
      P08050
      Related
      ENSRNOP00000001054.2, ENSRNOT00000001054.4
      Conserved Domains (4) summary
      smart00037
      Location:4376
      CNX; Connexin homologues
      smart01089
      Location:165231
      Connexin_CCC; Gap junction channel protein cysteine-rich domain
      pfam00029
      Location:3233
      Connexin; Connexin
      pfam03508
      Location:293312
      Connexin43; Gap junction alpha-1 protein (Cx43)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

      Range
      37876650..37889097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000088.1 Alternate Rn_Celera

      Range
      37095121..37107568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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