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    Tyrobp TYRO protein tyrosine kinase binding protein [ Mus musculus (house mouse) ]

    Gene ID: 22177, updated on 8-Apr-2018
    Official Symbol
    Tyrobpprovided by MGI
    Official Full Name
    TYRO protein tyrosine kinase binding proteinprovided by MGI
    Primary source
    MGI:MGI:1277211
    See related
    Ensembl:ENSMUSG00000030579 Vega:OTTMUSG00000059315
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly83; DAP12; KARAP
    Expression
    Broad expression in spleen adult (RPKM 223.3), lung adult (RPKM 120.3) and 21 other tissues See more
    Orthologs
    Location:
    7 B1; 7 17.45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (30413788..30417582)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (31198807..31202601)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 42376 Neighboring gene predicted gene, 32029 Neighboring gene hematopoietic cell signal transducer Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    macrophage activation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neutrophil activation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    osteoclast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of osteoclast development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    TYRO protein tyrosine kinase-binding protein
    Names
    DNAX-activation protein 12
    KAR-associated protein
    killer cell activating receptor associated protein
    killer-activating receptor-associated protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011662.2NP_035792.1  TYRO protein tyrosine kinase-binding protein precursor

      See identical proteins and their annotated locations for NP_035792.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056450
      Consensus CDS
      CCDS21089.1
      UniProtKB/Swiss-Prot
      O54885
      UniProtKB/TrEMBL
      Q3U419
      Related
      ENSMUSP00000032800.9, ENSMUST00000032800.9
      Conserved Domains (1) summary
      pfam07213
      Location:2272
      DAP10; DAP10 membrane protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      30413788..30417582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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