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    LMO4 LIM domain only 4 [ Homo sapiens (human) ]

    Gene ID: 8543, updated on 12-Mar-2017
    Official Symbol
    LMO4provided by HGNC
    Official Full Name
    LIM domain only 4provided by HGNC
    Primary source
    HGNC:HGNC:6644
    See related
    Ensembl:ENSG00000143013 MIM:603129; Vega:OTTHUMG00000010248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The encoded protein may play a role as a transcriptional regulator or as an oncogene. [provided by RefSeq, Aug 2008]
    Orthologs
    Location:
    1p22.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (87328468..87348923)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (87794151..87814606)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1140 Neighboring gene uncharacterized LOC101927844 Neighboring gene long intergenic non-protein coding RNA 1364 Neighboring gene uncharacterized LOC105378833

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
    NHGRI GWA Catalog
    Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enhancer sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of protein complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    neural tube closure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spinal cord association neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    spinal cord motor neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ventral spinal cord interneuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular septum development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell leading edge ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    LIM domain transcription factor LMO4
    Names
    LIM domain only protein 4
    LIM-only 4 protein
    LMO-4
    breast tumor autoantigen

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006769.3NP_006760.1  LIM domain transcription factor LMO4

      See identical proteins and their annotated locations for NP_006760.1

      Status: REVIEWED

      Source sequence(s)
      AC092392, AI962216, AW162477, BU580860, BU619915, U24576
      Consensus CDS
      CCDS713.1
      UniProtKB/Swiss-Prot
      P61968
      Related
      ENSP00000359575, OTTHUMP00000011905, ENST00000370544, OTTHUMT00000028264
      Conserved Domains (2) summary
      cd09386
      Location:2377
      LIM1_LMO4; The first LIM domain of LMO4 (LIM domain only protein 4)
      cd09387
      Location:87141
      LIM2_LMO4; The second LIM domain of LMO4 (LIM domain only protein 4)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      87328468..87348923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271291.3XP_005271348.1  LIM domain transcription factor LMO4 isoform X1

      See identical proteins and their annotated locations for XP_005271348.1

      UniProtKB/Swiss-Prot
      P61968
      Related
      ENSP00000359573, OTTHUMP00000011906, ENST00000370542, OTTHUMT00000028265
      Conserved Domains (2) summary
      cd09386
      Location:2377
      LIM1_LMO4; The first LIM domain of LMO4 (LIM domain only protein 4)
      cd09387
      Location:87141
      LIM2_LMO4; The second LIM domain of LMO4 (LIM domain only protein 4)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      87909001..87929485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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