Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Adamts5 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) [ Mus musculus (house mouse) ]

    Gene ID: 23794, updated on 27-May-2017
    Official Symbol
    Adamts5provided by MGI
    Official Full Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)provided by MGI
    Primary source
    MGI:MGI:1346321
    See related
    Ensembl:ENSMUSG00000022894
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ADMP-2; ASMP-2; ADAMTS1; ADAM-TS5; ADAMTS11; AI481094; 9530092O11Rik
    Summary
    This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. Mice lacking the encoded protein are protected from surgery-induced osteoarthritis and antigen-induced arthritis. [provided by RefSeq, May 2016]
    Orthologs
    Location:
    16 C3.3; 16 48.34 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (85858157..85901125, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (85858402..85901370, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930556C24 gene Neighboring gene a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 Neighboring gene predicted gene, 46558 Neighboring gene predicted gene, 32357 Neighboring gene predicted gene, 32461

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    extracellular matrix binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 5
    Names
    aggrecanase-2
    implantin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011782.2NP_035912.2  A disintegrin and metalloproteinase with thrombospondin motifs 5 preproprotein

      See identical proteins and their annotated locations for NP_035912.2

      Status: REVIEWED

      Source sequence(s)
      AC126936, AC163107, AK044746
      Consensus CDS
      CCDS28288.1
      UniProtKB/Swiss-Prot
      Q9R001
      UniProtKB/TrEMBL
      Q8BGP4
      Related
      ENSMUSP00000023611.5, ENSMUST00000023611.5
      Conserved Domains (6) summary
      smart00209
      Location:570622
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:269473
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:269476
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:68174
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:732852
      ADAM_spacer1; ADAM-TS Spacer 1
      cl15456
      Location:486556
      ADAM_CR; ADAM cysteine-rich

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      85858157..85901125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center