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    Pnkp polynucleotide kinase 3'- phosphatase [ Mus musculus (house mouse) ]

    Gene ID: 59047, updated on 5-Nov-2017
    Official Symbol
    Pnkpprovided by MGI
    Official Full Name
    polynucleotide kinase 3'- phosphataseprovided by MGI
    Primary source
    MGI:MGI:1891698
    See related
    Ensembl:ENSMUSG00000002963 Vega:OTTMUSG00000022325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PNK; 1810009G08Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 14.6), thymus adult (RPKM 14.2) and 28 other tissues See more
    Orthologs
    Location:
    7; 7 B3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (44856479..44862929)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (52112551..52118299)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 21948 Neighboring gene interleukin 4 induced 1 Neighboring gene TBC1 domain family, member 17 Neighboring gene AKT1 substrate 1 (proline-rich) Neighboring gene microRNA 707 Neighboring gene prostate tumor over expressed gene 1 Neighboring gene mediator complex subunit 25

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleotide kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    polynucleotide 3'-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    polynucleotide 3'-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA 3' dephosphorylation involved in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    DNA damage response, detection of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    polynucleotide 3' dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    bifunctional polynucleotide phosphatase/kinase
    Names
    DNA 5'-kinase/3'-phosphatase
    NP_001277693.1
    NP_001277695.1
    NP_001277696.1
    NP_067524.2
    XP_006541101.2
    XP_006541102.1
    XP_006541103.1
    XP_006541104.1
    XP_006541105.2
    XP_011249187.1
    XP_017177921.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290764.1NP_001277693.1  bifunctional polynucleotide phosphatase/kinase isoform a

      See identical proteins and their annotated locations for NP_001277693.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC158231, AK049992, BY118349, BY579541
      Consensus CDS
      CCDS39945.1
      UniProtKB/TrEMBL
      G5E8N7
      Related
      ENSMUSP00000103508.1, OTTMUSP00000025292, ENSMUST00000107876.7, OTTMUST00000053209
      Conserved Domains (3) summary
      cd01427
      Location:168288
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01663
      Location:3522
      PNK-3'Pase; polynucleotide 5'-kinase 3'-phosphatase
      cl17190
      Location:366442
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    2. NM_001290766.1NP_001277695.1  bifunctional polynucleotide phosphatase/kinase isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK049992, BC047269, BY118349, BY579541, CX223963
      Consensus CDS
      CCDS71955.1
      UniProtKB/TrEMBL
      E9Q9A5
      Related
      ENSMUSP00000096078.3, OTTMUSP00000025293, ENSMUST00000098478.6, OTTMUST00000053211
      Conserved Domains (3) summary
      cd01427
      Location:168255
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01663
      Location:3486
      PNK-3'Pase; polynucleotide 5'-kinase 3'-phosphatase
      cl17190
      Location:330406
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    3. NM_001290767.1NP_001277696.1  bifunctional polynucleotide phosphatase/kinase isoform c

      See identical proteins and their annotated locations for NP_001277696.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon and uses a downstream start codon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AK049992, BY579541, CK628081
      Conserved Domains (3) summary
      TIGR01664
      Location:1110
      DNA-3'-Pase; DNA 3'-phosphatase
      pfam13671
      Location:148270
      AAA_33; AAA domain
      cl17190
      Location:148224
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    4. NM_021549.3NP_067524.2  bifunctional polynucleotide phosphatase/kinase isoform a

      See identical proteins and their annotated locations for NP_067524.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC158231, AK049992, BY118349, BY579541, CX223963
      Consensus CDS
      CCDS39945.1
      UniProtKB/TrEMBL
      G5E8N7
      Related
      ENSMUSP00000003044.7, OTTMUSP00000025291, ENSMUST00000003044.13, OTTMUST00000053208
      Conserved Domains (3) summary
      cd01427
      Location:168288
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01663
      Location:3522
      PNK-3'Pase; polynucleotide 5'-kinase 3'-phosphatase
      cl17190
      Location:366442
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      44856479..44862929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322432.1XP_017177921.1  bifunctional polynucleotide phosphatase/kinase isoform X7

    2. XM_006541039.3XP_006541102.1  bifunctional polynucleotide phosphatase/kinase isoform X2

      Conserved Domains (3) summary
      cd01427
      Location:232352
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01663
      Location:67524
      PNK-3'Pase; polynucleotide 5'-kinase 3'-phosphatase
      cl17190
      Location:414484
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    3. XM_006541040.2XP_006541103.1  bifunctional polynucleotide phosphatase/kinase isoform X3

      Conserved Domains (3) summary
      cd01427
      Location:232319
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01663
      Location:67510
      PNK-3'Pase; polynucleotide 5'-kinase 3'-phosphatase
      cl17190
      Location:394470
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    4. XM_006541041.3XP_006541104.1  bifunctional polynucleotide phosphatase/kinase isoform X4

      Conserved Domains (3) summary
      cd01427
      Location:168288
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01663
      Location:3482
      PNK-3'Pase; polynucleotide 5'-kinase 3'-phosphatase
      cl17190
      Location:366442
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    5. XM_006541038.3XP_006541101.2  bifunctional polynucleotide phosphatase/kinase isoform X1

      Conserved Domains (3) summary
      cd01427
      Location:182302
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01663
      Location:17496
      PNK-3'Pase; polynucleotide 5'-kinase 3'-phosphatase
      cl17190
      Location:380456
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    6. XM_011250885.2XP_011249187.1  bifunctional polynucleotide phosphatase/kinase isoform X6

      Conserved Domains (3) summary
      cd01427
      Location:182269
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01663
      Location:17500
      PNK-3'Pase; polynucleotide 5'-kinase 3'-phosphatase
      cl17190
      Location:344420
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    7. XM_006541042.3XP_006541105.2  bifunctional polynucleotide phosphatase/kinase isoform X5

      Conserved Domains (3) summary
      cd01427
      Location:182302
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01663
      Location:17536
      PNK-3'Pase; polynucleotide 5'-kinase 3'-phosphatase
      cl17190
      Location:380456
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RNA

    1. XR_001785594.1 RNA Sequence

    2. XR_001785593.1 RNA Sequence

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