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    DNM2 dynamin 2 [ Homo sapiens (human) ]

    Gene ID: 1785, updated on 22-Apr-2017
    Official Symbol
    DNM2provided by HGNC
    Official Full Name
    dynamin 2provided by HGNC
    Primary source
    HGNC:HGNC:2974
    See related
    Ensembl:ENSG00000079805 MIM:602378; Vega:OTTHUMG00000180694
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DYN2; CMT2M; DYNII; LCCS5; CMTDI1; CMTDIB; DI-CMTB
    Summary
    Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
    Orthologs
    Location:
    19p13.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (10718053..10831910)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10828729..10944169)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene interleukin enhancer binding factor 3 Neighboring gene queuine tRNA-ribosyltransferase catalytic subunit 1 Neighboring gene microRNA 638 Neighboring gene microRNA 4748 Neighboring gene microRNA 199a-1 Neighboring gene microRNA 6793 Neighboring gene chromosome 19 open reading frame 38 Neighboring gene transmembrane p24 trafficking protein 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of dynamin 2 (DNM2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
    Knockdown of dynamin 2 by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify dynamin 2 (DNM2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Envelope transmembrane glycoprotein gp41 env The cytoplasmic tail, in particular amino acids 718-723, of HIV-1 gp41 is an important determinant for dynasore (a dynamin inhibitor) sensitivity in HIV-mediated cell-cell fusion PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify dynamin 2 (DNM2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify dynamin 2 (DNM2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    nef Dyn2 is required for the infectivity enhancement function of Nef. The K44A mutant of Dyn2 markedly reduces the infectivity of nef-positive HIV PubMed
    nef Nef specifically interacts with dynamin 2 (Dyn2) in an in vitro pull-down assay. The middle domain and the GED of Dyn2 are both necessary and together confer full Nef binding while the myristyl moiety of Nef is critical for the interaction with Dyn2 PubMed
    nef HIV-1 Nef enhances the infectivity of CD4-chemokine receptor-pseudotyped HIV-1 for target cells expressing HIV-1 Env. Virus-producing cells expressing dominant-negative dynamin 2 (K44A) selectively inhibits these receptor-pseudotyped virions PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify dynamin 2 (DNM2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    gag Dynamin-dependent endocytosis is required for intracellular accumulation of HIV-1 Gag in the presence of HLA-DR PubMed
    gag HIV-1 Gag co-localizes with dynamin in primary T lymphocytes PubMed
    Vpu vpu Dominant negative dynamin 2 (K44A) acts as an inhibitor of clathrin-mediated endocytosis and inhibits the downregulation of BST-2 from the cell surface by HIV-1 Vpu PubMed
    capsid gag Dynamin 2 depletion by shRNA results in inhibition of the HIV-1 CA uptake by target cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
      Arf6 trafficking events, organism-specific biosystem
      Arf6 trafficking events
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Clathrin derived vesicle budding, organism-specific biosystem (from REACTOME)
      Clathrin derived vesicle budding, organism-specific biosystemThere at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the cl...
    • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem (from KEGG)
      Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
    • Endocrine and other factor-regulated calcium reabsorption, conserved biosystem (from KEGG)
      Endocrine and other factor-regulated calcium reabsorption, conserved biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Formation of annular gap junctions, organism-specific biosystem (from REACTOME)
      Formation of annular gap junctions, organism-specific biosystemGap junction plaque internalization and the disruption cell communication requires a reorganization of Cx molecular interactions. Proteins including Dab-2, AP-2, Dynamin and Myosin VI associate w...
    • Gap junction degradation, organism-specific biosystem (from REACTOME)
      Gap junction degradation, organism-specific biosystemThe half-life of Cx is very short (1 to 5h) compared to other junctional proteins (Laird et al., 1995 ; Fallon and Goudenough, 1981). Connexins are targeted for degradation by the proteasome and the...
    • Gap junction trafficking, organism-specific biosystem (from REACTOME)
      Gap junction trafficking, organism-specific biosystemGap junctions are intercellular communication channels formed from Cx (connexin) protein subunits (see Segretain and Falk 2004 and Evans et al. 2006 for comprehensive reviews). Connexins are transpor...
    • Gap junction trafficking and regulation, organism-specific biosystem (from REACTOME)
      Gap junction trafficking and regulation, organism-specific biosystemGap junctions are clusters of intercellular channels connecting adjacent cells and permitting the direct exchange of ions and small molecules between cells. These channels are composed of two hemicha...
    • Golgi Associated Vesicle Biogenesis, organism-specific biosystem (from REACTOME)
      Golgi Associated Vesicle Biogenesis, organism-specific biosystemProteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell ...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • Lysosome Vesicle Biogenesis, organism-specific biosystem (from REACTOME)
      Lysosome Vesicle Biogenesis, organism-specific biosystemProteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell ...
    • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
      MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of nitric oxide, organism-specific biosystem (from REACTOME)
      Metabolism of nitric oxide, organism-specific biosystemNitric oxide (NO), a multifunctional second messenger, is implicated in physiological functions in mammals that range from immune response and potentiation of synaptic transmission to dilation of blo...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • NOSTRIN mediated eNOS trafficking, organism-specific biosystem (from REACTOME)
      NOSTRIN mediated eNOS trafficking, organism-specific biosystemeNOS traffic inducer (NOSTRIN) is a novel 506-amino acid eNOS-interacting protein. Along with a decrease in eNOS activity, NOSTRIN causes translocation of eNOS from the plasma membrane to intracellu...
    • PDGFR-beta signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      PDGFR-beta signaling pathway, organism-specific biosystem
      PDGFR-beta signaling pathway
    • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
      Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
      Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Recycling pathway of L1, organism-specific biosystem (from REACTOME)
      Recycling pathway of L1, organism-specific biosystemL1 functions in many aspects of neuronal development including axon outgrowth and neuronal migration. These functions require coordination between L1 and the actin cytoskeleton. F-actin continuously ...
    • Retrograde neurotrophin signalling, organism-specific biosystem (from REACTOME)
      Retrograde neurotrophin signalling, organism-specific biosystemNeurotrophin-TRK complexes can be internalized and enter signalling vesicles, which travel retrogradely over long distances from distal nerve terminals to neuronal cell bodies. Such retrograde signal...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Synaptic Vesicle Pathway, organism-specific biosystem (from WikiPathways)
      Synaptic Vesicle Pathway, organism-specific biosystemPathway depicting synaptic transmission of neurotransmitters from the presynaptic nerve terminal to the synaptic cleft upon depolarization. Synaptotagmin mediated transport along the nerve cell cytos...
    • Synaptic vesicle cycle, organism-specific biosystem (from KEGG)
      Synaptic vesicle cycle, organism-specific biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
    • Synaptic vesicle cycle, conserved biosystem (from KEGG)
      Synaptic vesicle cycle, conserved biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
    • Syndecan-4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-4-mediated signaling events, organism-specific biosystem
      Syndecan-4-mediated signaling events
    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
    • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
      Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    • eNOS activation and regulation, organism-specific biosystem (from REACTOME)
      eNOS activation and regulation, organism-specific biosystemOriginally identified as endothelium-derived relaxing factor, eNOS derived NO is a critical signaling molecule in vascular homeostasis. It regulates blood pressure and vascular tone, and is involved...
    • trans-Golgi Network Vesicle Budding, organism-specific biosystem (from REACTOME)
      trans-Golgi Network Vesicle Budding, organism-specific biosystemAfter passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membran...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    D2 dopamine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    GTPase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    GTPase activity TAS
    Traceable Author Statement
    more info
     
    SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    WW domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nitric-oxide synthase binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol 3-kinase regulatory subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    G2/M transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Golgi to plasma membrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
    Traceable Author Statement
    more info
     
    aorta development IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to X-ray IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to carbon monoxide IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to dopamine IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to nitric oxide IEA
    Inferred from Electronic Annotation
    more info
     
    coronary vasculature development IEA
    Inferred from Electronic Annotation
    more info
     
    dynamin family protein polymerization involved in mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endocytosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    macropinocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane organization TAS
    Traceable Author Statement
    more info
     
    mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of membrane tubulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of non-motile cilium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of sodium:potassium-exchanging ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of Golgi organization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Rac protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of nitric-oxide synthase activity TAS
    Traceable Author Statement
    more info
     
    regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    response to light stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transferrin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular septum development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-coated endocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-coated pit ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbody IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytic cup IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    photoreceptor inner segment IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    dynamin-2
    Names
    dynamin II
    NP_001005360.1
    NP_001005361.1
    NP_001005362.1
    NP_001177645.1
    NP_004936.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008792.1 RefSeqGene

      Range
      4975..118832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_238

    mRNA and Protein(s)

    1. NM_001005360.2NP_001005360.1  dynamin-2 isoform 1

      See identical proteins and their annotated locations for NP_001005360.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes one of the longer isoforms (1).
      Source sequence(s)
      AC011475, AC011552, AC112707, BC039596, BC054501, BU621654, DB069057
      Consensus CDS
      CCDS45968.1
      UniProtKB/Swiss-Prot
      P50570
      Related
      ENSP00000347890.6, OTTHUMP00000264987, ENST00000355667.10, OTTHUMT00000452592
      Conserved Domains (7) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:78500
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam00169
      Location:520623
      PH; PH domain
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:651739
      GED; Dynamin GTPase effector domain
      pfam16666
      Location:758822
      MAGI_u5; Unstructured region on MAGI
    2. NM_001005361.2NP_001005361.1  dynamin-2 isoform 2

      See identical proteins and their annotated locations for NP_001005361.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and includes an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is the same length as isoform 1 but differs in an internal region, compared to isoform 1.
      Source sequence(s)
      AC011475, AC011552, AC112707, AK097875, BC039596, BU621654, DB069057
      Consensus CDS
      CCDS45969.1
      UniProtKB/Swiss-Prot
      P50570
      UniProtKB/TrEMBL
      Q8N1K8
      Related
      ENSP00000373905.3, OTTHUMP00000264990, ENST00000389253.8, OTTHUMT00000452604
      Conserved Domains (7) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:78500
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam00169
      Location:520623
      PH; PH domain
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:651739
      GED; Dynamin GTPase effector domain
      pfam16666
      Location:758822
      MAGI_u5; Unstructured region on MAGI
    3. NM_001005362.2NP_001005362.1  dynamin-2 isoform 4

      See identical proteins and their annotated locations for NP_001005362.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons and includes an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 4) is shorter, compared to isoform 1.
      Source sequence(s)
      AC011475, AC011552, AC112707, AK289831, BC039596, BU621654, DB069057
      Consensus CDS
      CCDS32908.1
      UniProtKB/Swiss-Prot
      P50570
      Related
      ENSP00000386192.3, OTTHUMP00000264988, ENST00000408974.8, OTTHUMT00000452593
      Conserved Domains (7) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:78532
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:514625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam00169
      Location:516619
      PH; PH domain
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:647735
      GED; Dynamin GTPase effector domain
      pfam16666
      Location:754818
      MAGI_u5; Unstructured region on MAGI
    4. NM_001190716.1NP_001177645.1  dynamin-2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks 3 nts at an alternate splice site, compared to variant 1. The resulting protein (isoform 5) lacks one aa in the C-terminus, compared to isoform 1.
      Source sequence(s)
      AK312260, BC039596, BU621654, DB069057
      Consensus CDS
      CCDS59351.1
      UniProtKB/Swiss-Prot
      P50570
      Related
      ENSP00000468734.1, OTTHUMP00000264985, ENST00000585892.5, OTTHUMT00000452590
      Conserved Domains (7) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:78500
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:520629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam00169
      Location:520623
      PH; PH domain
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:651739
      GED; Dynamin GTPase effector domain
      pfam16666
      Location:758822
      MAGI_u5; Unstructured region on MAGI
    5. NM_004945.3NP_004936.2  dynamin-2 isoform 3

      See identical proteins and their annotated locations for NP_004936.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC011475, AC011552, AC112707, BC054501, BU621654, DB069057
      Consensus CDS
      CCDS32907.1
      UniProtKB/Swiss-Prot
      P50570
      Related
      ENSP00000352721.6, OTTHUMP00000264986, ENST00000359692.10, OTTHUMT00000452591
      Conserved Domains (7) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:78532
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:514625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam00169
      Location:516619
      PH; PH domain
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:647735
      GED; Dynamin GTPase effector domain
      pfam16666
      Location:754818
      MAGI_u5; Unstructured region on MAGI

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      10718053..10831910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      10829940..10943823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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