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    SUMO4 small ubiquitin-like modifier 4 [ Homo sapiens (human) ]

    Gene ID: 387082, updated on 9-Apr-2017
    Official Symbol
    SUMO4provided by HGNC
    Official Full Name
    small ubiquitin-like modifier 4provided by HGNC
    Primary source
    HGNC:HGNC:21181
    See related
    Ensembl:ENSG00000177688 MIM:608829; Vega:OTTHUMG00000015785
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IDDM5; SMT3H4; SUMO-4; dJ281H8.4
    Summary
    This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    6q25.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (149400359..149401046)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149721284..149722182)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TGF-beta activated kinase 1/MAP3K7 binding protein 2 Neighboring gene RNA, 7SL, cytoplasmic 234, pseudogene Neighboring gene fatty acid binding protein 12 pseudogene 1 Neighboring gene zinc finger CCCH-type containing 12D Neighboring gene coiled-coil domain containing 59 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Nuclear pore complex, organism-specific biosystem (from KEGG)
      Nuclear pore complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • Nuclear pore complex, conserved biosystem (from KEGG)
      Nuclear pore complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein tag IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    small ubiquitin-related modifier 4
    Names
    SMT3 suppressor of mif two 3 homolog 2
    SMT3 suppressor of mif two 3 homolog 4
    insulin-dependent diabetes mellitus 5
    small ubiquitin-like modifier 4 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012301.1 RefSeqGene

      Range
      5001..5688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001002255.1NP_001002255.1  small ubiquitin-related modifier 4

      See identical proteins and their annotated locations for NP_001002255.1

      Status: REVIEWED

      Source sequence(s)
      AY340238
      Consensus CDS
      CCDS34549.1
      UniProtKB/Swiss-Prot
      Q6EEV6
      Related
      ENSP00000318635.4, OTTHUMP00000017390, ENST00000326669.5, OTTHUMT00000042638
      Conserved Domains (2) summary
      cd01763
      Location:893
      Sumo; Small ubiquitin-related modifier (SUMO)
      smart00213
      Location:1886
      UBQ; Ubiquitin homologues

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      149400359..149401046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      149986244..149986931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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