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    NOD1 nucleotide binding oligomerization domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 10392, updated on 12-Mar-2017
    Official Symbol
    NOD1provided by HGNC
    Official Full Name
    nucleotide binding oligomerization domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:16390
    See related
    Ensembl:ENSG00000106100 MIM:605980; Vega:OTTHUMG00000023923
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CARD4; NLRC1; CLR7.1
    Summary
    This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009]
    Orthologs
    Location:
    7p14.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (30424527..30478840, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (30464143..30518426, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized protein DKFZp586I1420 Neighboring gene long intergenic non-protein coding RNA 1176 Neighboring gene uncharacterized LOC101928268 Neighboring gene gamma-glutamylcyclotransferase Neighboring gene golgin A8 family member A pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
      Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem (from KEGG)
      Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
    • Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem (from KEGG)
      Epithelial cell signaling in Helicobacter pylori infection, conserved biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
    • JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, organism-specific biosystem (from REACTOME)
      JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, organism-specific biosystemC-Jun NH2 terminal kinases (JNKs) are an evolutionarily conserved family of serine/threonine protein kinases, that belong to mitogen activated protein kinase family (MAPKs - also known as stress-acti...
    • MAP kinase activation in TLR cascade, organism-specific biosystem (from REACTOME)
      MAP kinase activation in TLR cascade, organism-specific biosystemThe mitogen activated protein kinase (MAPK) cascade, one of the most ancient and evolutionarily conserved signaling pathways, is involved in many processes of immune responses. The MAP kinases cascad...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
    • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
      MyD88 dependent cascade initiated on endosome, organism-specific biosystemUpon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I ...
    • MyD88-independent TLR3/TLR4 cascade, organism-specific biosystem (from REACTOME)
      MyD88-independent TLR3/TLR4 cascade, organism-specific biosystemMyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from ...
    • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD1/2 Signaling Pathway, organism-specific biosystem (from REACTOME)
      NOD1/2 Signaling Pathway, organism-specific biosystemNOD1 is ubiquitously expressed, while NOD2 expression is restricted to monocytes, macrophages, dendritic cells, and intestinal Paneth cells (Inohara et al. 2005). NOD1 and NOD2 activation induces tra...
    • Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystem (from WikiPathways)
      Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystemThe NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importa...
    • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
      Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemThe innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of an...
    • Ovarian tumor domain proteases, organism-specific biosystem (from REACTOME)
      Ovarian tumor domain proteases, organism-specific biosystemHumans have 16 Overian tumour domain (OTU) family DUBs that can be evolutionally divided into three classes, the OTUs, the Otubains (OTUBs), and the A20-like OTUs (Komander et al. 2009). OTU family ...
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Shigellosis, organism-specific biosystem (from KEGG)
      Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystem (from REACTOME)
      TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystemNF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting...
    • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
    • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
      TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemTRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists...
    • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
    • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
    • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
    • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
    • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
    • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
    • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
    • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
    • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
      Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • activated TAK1 mediates p38 MAPK activation, organism-specific biosystem (from REACTOME)
      activated TAK1 mediates p38 MAPK activation, organism-specific biosystemp38 mitogen-activated protein kinase (MAPK) belongs to a highly conserved family of serine/threonine protein kinases. The p38 MAPK-dependent signaling cascade is activated by pro-inflammatory or stre...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    CARD domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cysteine-type endopeptidase activator activity involved in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    peptidoglycan binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    JNK cascade TAS
    Traceable Author Statement
    more info
     
    activation of MAPK activity TAS
    Traceable Author Statement
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to muramyl dipeptide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    detection of bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    detection of biotic stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-8 biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide-binding oligomerization domain containing signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity TAS
    Traceable Author Statement
    more info
     
    positive regulation of NIK/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of dendritic cell antigen processing and presentation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-1 beta production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nitric-oxide synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of xenophagy IEA
    Inferred from Electronic Annotation
    more info
     
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    protein oligomerization TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    nucleotide-binding oligomerization domain-containing protein 1
    Names
    NLR family, CARD domain containing 1
    caspase recruitment domain family, member 4
    caspase recruitment domain-containing protein 4
    nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013025.1 RefSeqGene

      Range
      5001..59251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006092.2NP_006083.1  nucleotide-binding oligomerization domain-containing protein 1

      See identical proteins and their annotated locations for NP_006083.1

      Status: REVIEWED

      Source sequence(s)
      AA845215, AF113925, BC040339, CV569884
      Consensus CDS
      CCDS5427.1
      UniProtKB/Swiss-Prot
      Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73
      Related
      ENSP00000222823, OTTHUMP00000158742, ENST00000222823, OTTHUMT00000250443
      Conserved Domains (5) summary
      smart00382
      Location:194291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676941
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197367
      NACHT; NACHT domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      30424527..30478840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515081.2XP_011513383.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011513383.1

      UniProtKB/Swiss-Prot
      Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73
      Conserved Domains (5) summary
      smart00382
      Location:194291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676941
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197367
      NACHT; NACHT domain
    2. XM_005249572.1XP_005249629.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005249629.1

      UniProtKB/Swiss-Prot
      Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73
      Conserved Domains (5) summary
      smart00382
      Location:194291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676941
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197367
      NACHT; NACHT domain
    3. XM_011515079.1XP_011513381.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011513381.1

      UniProtKB/Swiss-Prot
      Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73
      Conserved Domains (5) summary
      smart00382
      Location:194291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676941
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197367
      NACHT; NACHT domain
    4. XM_011515083.1XP_011513385.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X2

      Conserved Domains (5) summary
      smart00382
      Location:194291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676925
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197367
      NACHT; NACHT domain
    5. XM_011515085.1XP_011513387.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X5

      Conserved Domains (4) summary
      cd00116
      Location:723858
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730754
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197367
      NACHT; NACHT domain
    6. XM_011515084.1XP_011513386.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X4

      Conserved Domains (5) summary
      smart00382
      Location:194291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676914
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197367
      NACHT; NACHT domain
    7. XM_005249568.1XP_005249625.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005249625.1

      UniProtKB/Swiss-Prot
      Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73
      Conserved Domains (5) summary
      smart00382
      Location:194291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676941
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197367
      NACHT; NACHT domain
    8. XM_017011675.1XP_016867164.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X4

      Conserved Domains (5) summary
      smart00382
      Location:194291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676914
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197367
      NACHT; NACHT domain
    9. XM_006715633.2XP_006715696.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006715696.1

      UniProtKB/Swiss-Prot
      Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73
      Conserved Domains (5) summary
      smart00382
      Location:194291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676941
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197367
      NACHT; NACHT domain
    10. XM_011515080.2XP_011513382.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011513382.1

      UniProtKB/Swiss-Prot
      Q9Y239
      UniProtKB/TrEMBL
      A0A024RA73
      Conserved Domains (5) summary
      smart00382
      Location:194291
      AAA; ATPases associated with a variety of cellular activities
      cd00116
      Location:676941
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197367
      NACHT; NACHT domain
    11. XM_005249576.1XP_005249633.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X8

      Conserved Domains (3) summary
      cd00116
      Location:428693
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:482509
      LRR_RI; leucine-rich repeat [structural motif]
      cl21455
      Location:3119
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    12. XM_017011674.1XP_016867163.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

    13. XM_011515087.1XP_011513389.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X6

      Conserved Domains (5) summary
      COG5635
      Location:89542
      COG5635; Predicted NTPase, NACHT family domain [Signal transduction mechanisms]
      cd00116
      Location:723821
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08324
      Location:21105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      sd00033
      Location:730757
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:197367
      NACHT; NACHT domain
    14. XM_011515088.2XP_011513390.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X7

      See identical proteins and their annotated locations for XP_011513390.1

      UniProtKB/TrEMBL
      G3XAL1
      Related
      ENSP00000416946, OTTHUMP00000202484, ENST00000434755, OTTHUMT00000328033
      Conserved Domains (3) summary
      smart00382
      Location:194291
      AAA; ATPases associated with a variety of cellular activities
      cd08324
      Location:21105
      CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
      pfam05729
      Location:197367
      NACHT; NACHT domain

    RNA

    1. XR_926908.2 RNA Sequence

    2. XR_001744529.1 RNA Sequence

    3. XR_926909.2 RNA Sequence

    4. XR_926910.1 RNA Sequence

    5. XR_001744530.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      30464171..30518245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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