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    braf B-Raf proto-oncogene, serine/threonine kinase [ Danio rerio (zebrafish) ]

    Gene ID: 403065, updated on 9-Apr-2018
    Official Symbol
    brafprovided by ZNC
    Official Full Name
    B-Raf proto-oncogene, serine/threonine kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040805-1
    See related
    Ensembl:ENSDARG00000017661 Vega:OTTDARG00000007629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    sierrabraf
    Orthologs
    Location:
    chromosome: 4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (12072421..12102123, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (12073572..12103187, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene si:dkey-222f8.3 Neighboring gene uncharacterized LOC101883576 Neighboring gene troponin T2c, cardiac Neighboring gene uncharacterized LOC108183387 Neighboring gene mitochondrial ribosomal protein S33 Neighboring gene transmembrane protein 178B

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    mitogen-activated protein kinase kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer activity, downstream of receptor IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    serine/threonine-protein kinase B-raf
    Names
    serine/threonine protein kinase BRAF
    v-raf murine sarcoma viral oncogene homolog B1
    NP_001311445.1
    NP_991307.3
    XP_021330649.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324516.1NP_001311445.1  serine/threonine-protein kinase B-raf isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX005210
      UniProtKB/TrEMBL
      Q1LYG2
      Related
      ENSDARP00000048390.8, OTTDARP00000018002, ENSDART00000048391.10, OTTDART00000021369
      Conserved Domains (4) summary
      cd01816
      Location:166237
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14062
      Location:513765
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      pfam00130
      Location:245290
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam07714
      Location:507764
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_205744.4NP_991307.3  serine/threonine-protein kinase B-raf isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC162198, BX005210
      UniProtKB/TrEMBL
      B3DFX5
      Related
      ENSDARP00000016253.10, OTTDARP00000007439, ENSDART00000023894.11, OTTDART00000008625
      Conserved Domains (4) summary
      cd01816
      Location:166237
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14151
      Location:458731
      STKc_B-Raf; Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:245290
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam07714
      Location:467724
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      12072421..12102123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474974.1XP_021330649.1  serine/threonine-protein kinase B-raf isoform X1

      Conserved Domains (3) summary
      cd01816
      Location:166237
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      pfam00130
      Location:245290
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:458575
      PKc_like; Protein Kinases, catalytic domain
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